The ontogeny of serum insulin-like growth factor-I concentration in foals: Effects of dam parity, diet, and age at weaning

Cymbaluk, Nadia F.; Laarveld, B.

doi:10.1016/0739-7240(96)00014-8

Cited by 33 publications

(33 citation statements)

References 32 publications

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“…IGF-1 is one of the most important regulators of growth in the newborn, mediating most effects of growth hormone (GH). Plasma IGF-1 concentrations, although strongly related to the foal's breed and higher in pony compared to saddlebred foals, were consistent with previously published data [30], [49], [71] and followed similar trends, with increased concentrations between birth and 3 months of age, as described elsewhere [64], [71], [72]. In humans, IUGR babies have low plasma concentrations of IGF-1 [73].…”

Section: Discussionsupporting

confidence: 90%

Enhanced or Reduced Fetal Growth Induced by Embryo Transfer into Smaller or Larger Breeds Alters Post-Natal Growth and Metabolism in Pre-Weaning Horses

Peugnet

Wimel

Duchamp³

et al. 2014

PLoS ONE

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In equids, placentation is diffuse and nutrient supply to the fetus is determined by uterine size. This correlates with maternal size and affects intra-uterine development and subsequent post-natal growth, as well as insulin sensitivity in the newborn. Long-term effects remain to be described. In this study, fetal growth was enhanced or restricted through ET using pony (P), saddlebred (S) and draft (D) horses. Control P-P (n = 21) and S-S (n = 28) pregnancies were obtained by AI. Enhanced and restricted pregnancies were obtained by transferring P or S embryos into D mares (P-D, n = 6 and S-D, n = 8) or S embryos into P mares (S-P, n = 6), respectively. Control and experimental foals were raised by their dams and recipient mothers, respectively. Weight gain, growth hormones and glucose homeostasis were investigated in the foals from birth to weaning. Fetal growth was enhanced in P-D and these foals remained consistently heavier, with reduced T3 concentrations until weaning compared to P-P. P-D had lower fasting glucose from days 30 to 200 and higher insulin secretion than P-P after IVGTT on day 3. Euglycemic clamps in the immediate post-weaning period revealed no difference in insulin sensitivity between P-D and P-P. Fetal growth was restricted in S-P and these foals remained consistently lighter until weaning compared to S-D, with elevated T3 concentrations in the newborn compared to S-S. S-P exhibited higher fasting glycemia than S-S and S-D from days 30 to 200. They had higher maximum increment in plasma glucose than S-D after IVGTT on day 3 and clamps on day 200 demonstrated higher insulin sensitivity compared to S-D. Neither the restricted nor the enhanced fetal environment affected IGF-1 concentrations. Thus, enhanced and restricted fetal and post-natal environments had combined effects that persisted until weaning. They induced different adaptive responses in post-natal glucose metabolism: an early insulin-resistance was induced in enhanced P-D, while S-P developed increased insulin sensitivity.

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Section: Discussionsupporting

confidence: 90%

Enhanced or Reduced Fetal Growth Induced by Embryo Transfer into Smaller or Larger Breeds Alters Post-Natal Growth and Metabolism in Pre-Weaning Horses

Peugnet

Wimel

Duchamp³

et al. 2014

PLoS ONE

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“…A previous longitudinal study of Quarter HorseDraft crosses from 1-12 months of age found that serum IGF-1 concentrations were correlated with body weight (Cymbaluk and Laarveld, 1996). This relationship between circulating IGF-1 and growth is conserved in various species.…”

Section: Relationships Between Serum Igf-1 Concentrations and Body Simentioning

confidence: 99%

“…Although the literature concerning the chronology of the serum/plasma IGF-1 concentrations in horses during the post-natal period is limited, most studies have been performed comparing animals of different ages (Malinowski et al, 1996;Champion et al, 2002), with two longitudinal studies, one performed with a group of Quarter horse-draft crosses from one to 12 months of age and the other, with a group of growing Thoroughbreds from birth to 16 months of age (Cymbaluk and Laarveld, 1996;Staniar et al, 2007). It has been demonstrated that environmental conditions significantly influence pasture growth and composition and this fact would lead to different growth rates (Staniar et al, 2007).…”

Section: Design Of the Studymentioning

confidence: 99%

“…On the other hand, Tremblay et al (1993) found that Standardbred horses had higher circulating IGF-1 concentrations than Thoroughbreds. Serum IGF-1 concentrations have been reported in horses of different breeds, such as Thoroughbreds (Ozawa et al, 1995;Jackson et al, 2003;Fortier et al, 2005;Noble et al, 2007), Standardbred trotters (Malinowski et al, 1996;Champion et al, 2002), Belgian-cross and Quarter Horse-draft cross (Cymbaluk and Laarveld, 1996) and Quarter Horses (Ropp et al, 2003). To the authors' knowledge, the studies concerning comparative interbreeds are more limited (Tremblay et al, 1993;Ozawa et al, 1995;Cymbaluk and Laarveld, 1996).…”

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confidence: 99%

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A study of serum insulin-like growth factor type 1 (IGF-1) concentrations in resting untrained Andalusian horses: influence of age and gender

Muñoz¹,

Trigo²,

Riber³

et al. 2011

Vet. Med.

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Growth rate, tissue repair and reproductive functions are mediated by the somatotrophic axis, the growth hormone (GH) being one of its main components. GH is released in a pulsatile manner and a single measurement does not provide accurate information on the activity of the somatotrophic axis. The actions of GH on tissues are mediated by insulin-like growth factor type 1 (IGF-1), mainly released by the liver, and thus, the measurement of IGF-1 could be considered a good indicator of the activity of GH and the somatotrophic axis. Serum IGF-1 concentrations are relatively stable due to its long biological half-life without obvious diurnal rhythm. Additionally, many diseases significantly alter circulating IGF-1 concentrations, leading to potential diagnostic and prognostic uses in veterinary medicine. However, serum IGF-1 concentrations are affected by many factors, such as breed, age and sex. The present study analyzes the influence of these factors on serum IGF-1 concentrations in a population of 255 Andalusian horses (141 females and 114 males), divided into age groups: 1-2, 2-3, 3-4, 4-5, 5-6 and 6-12 months and 1-2, 2-4, 4-6, 6-10 and 10-14 years. The animals belonged to six different farms located in the same geographic location and were subjected to similar feeding and management protocols. Two measurements of body size were made: height at the withers (HW) and diameter of the thorax (DTx). Blood samples were taken always in the morning, in the month of July and serum IGF-1 concentrations were measured with a sandwich ELISA after dissociation of IGF-1 from its binding proteins. It was found that age and sex significantly influenced serum IGF-1 concentrations, whereas the effects of the farm and the time of blood withdrawal were not significant. Mean serum concentrations for both males and females respectively were: 246.3 and 231.0 (1-2 months), 201.9 and 194.7 (2-3 months), 174.2 and 170.4 (3-4 months), 161.7 and 155.4 (4-5 months), 166.1 and 136.9 (5-6 months), 127.2-114.5 (6-12 months), 103.3 and 89.01 (1-2 years), 104.3 and 73.41 (2-4 years), 105.4 and 64.40 (4-6 years), 53.29 and 68.27 (6-10 years) and 59.56 and 65.53 ng/ml (10-14 years). A progressive decrease in serum IGF-1 concentrations with increased age was found for both sexes. Males aged between five and 12 months and between two and six years had significantly higher serum IGF-1 concentrations than females of the same age. Coefficients of correlation between the indicators of body size (HW and DTx) and IGF-1 were -0.800 and -0.690 for the whole population of Andalusian horses, -0.860 and -0.750 for the males and -0.740 and -630 for the females. It is concluded that serum IGF-1 concentrations in Andalusian horses are reduced with ageing, male horses of determined age groups had higher IGF-1 than the females and there are negative correlations between body size and IGF-1 concentrations. The knowledge of the normal serum IGF-1 concentrations will help us to understand the role of the somatotrophic axis in several diseases and physiologic...

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“…[4][5][6] The most widely studied are human milk, cow's milk, and mare's milk, and it has been shown that the highest degree of similarity occurs between human and mare's milks. 7 Several biologically active factors, which may contribute to modulating cell proliferation and counteract infection and inflammatory responses, have been detected in human, 8 cow's, 9 and mare's [10][11][12] milk. In general, most bioactive substances are more abundant in colostrum than in milk, 5,12 but in both they usually exceed the concentration occurring in the mother's plasma.…”

Section: Introductionmentioning

confidence: 99%

Mare's Colostrum Globules Stimulate Fibroblast GrowthIn Vitro: A Biochemical Study

Zava

Barello

Pessione

et al. 2009

Journal of Medicinal Food

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The wound repair function of mare's milk and colostrum was investigated. Mare's colostrum improved wound healing in vivo; thus fibroblast growth activation by mare's milk and colostrum was examined. As expected, colostrum was more effective than milk. To establish the biochemical nature of the bioactive molecules involved, colostrum was fractionated into whey, casein, and fat globules, and the efficacy of these fractions on fibroblast proliferation was studied. The fat globule fraction provided the strongest stimulation; its composition was studied and compared with the less-active milk fat globule fraction. The lipid pattern highlighted several differences between mare's colostrum and milk; in particular, total lipid, linoleic acid, linolenic acid, ganglioside, and glycolipid contents were higher in colostrum. A proteomic investigation revealed some differences between the protein composition of colostrum and milk fat globules. Adipophylin and lactadherin were significantly overexpressed in colostrum fat globules. The role of specific lipids on skin wound repair and that of the epidermal growth factor-like domain, embedded within the lactadherin molecule and probably released in conditions stimulating proteolysis, are discussed.

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The ontogeny of serum insulin-like growth factor-I concentration in foals: Effects of dam parity, diet, and age at weaning

Cited by 33 publications

References 32 publications

Enhanced or Reduced Fetal Growth Induced by Embryo Transfer into Smaller or Larger Breeds Alters Post-Natal Growth and Metabolism in Pre-Weaning Horses

Enhanced or Reduced Fetal Growth Induced by Embryo Transfer into Smaller or Larger Breeds Alters Post-Natal Growth and Metabolism in Pre-Weaning Horses

A study of serum insulin-like growth factor type 1 (IGF-1) concentrations in resting untrained Andalusian horses: influence of age and gender

Mare's Colostrum Globules Stimulate Fibroblast GrowthIn Vitro: A Biochemical Study

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