In contrast to the robust mutual interpretability phenomenon in set theory, Ali Enayat proved that bi-interpretation is absent: distinct theories extending ZF are never bi-interpretable and models of ZF are bi-interpretable only when they are isomorphic. Nevertheless, for natural weaker set theories, we prove, including Zermelo-Fraenkel set theory ZFCwithout power set and Zermelo set theory Z, there are nontrivial instances of bi-interpretation. Specifically, there are well-founded models of ZFCthat are bi-interpretable, but not isomorphic-even H 1 , ∈ and H 2 , ∈ can be bi-interpretable-and there are distinct bi-interpretable theories extending ZFC -. Similarly, using a construction of Mathias, we prove that every model of ZF is bi-interpretable with a model of Zermelo set theory in which the replacement axiom fails.