Background: Distal radius fracture crush the mechanical foundation of man's most elegant tool the Hand .Fractures of the distal end of radius are amongst the most common fractures encountered by orthopedic surgeon and at times most challenging. The aim of this study was to assess the functional results of treatment of displaced, unstable, intra articular fractures of distal end of radius {DER} by open reduction and internal fixation {ORIF} and to develop a more comprehensive treatment protocol in all displaced, unstable, intra articular fractures of distal end of radius. Methods: This is a prospective study conducted on 25 patients of either sex in the age group of 20-50 years with displaced, unstable, intra articular fractures of distal end of radius managed by ORIF. Patients were followed up clinically and radiologically for a minimum period of 24 months. Results: There were 80% good to excellent results, 12% fair and 8% poor results. Conclusion: Our study support the new literature available in that open reduction and internal fixation is a very pertinent and satisfactory method in the treatment of these difficult and challenging fractures of displaced, unstable, intra articular fractures of distal end of radius in age group of 20-50 years.