The Ophthalmic Branch of the Gutenberg Health Study: Study Design, Cohort Profile and Self-Reported Diseases

Höhn, René; Kottler, Ulrike B.; Pető, Tünde; Blettner, Maria; Münzel, Thomas; Blankenberg, Stefan; Lackner, Karl J.; Beutel, Manfred E.; Wild, Philipp S.; Pfeiffer, Norbert

doi:10.1371/journal.pone.0120476

Cited by 91 publications

(81 citation statements)

References 32 publications

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“…Response to study invitation has to be considered as limitation in most population-based studies. In our study, the response was 60% [31]. As we do not have any knowledge about eye health in non-responders, we are not able to adjust for that people with low vision might be less likely to participate.…”

Section: Discussionmentioning

confidence: 99%

The impact of pseudophakia on vision-related quality of life in the general population – The Gutenberg Health Study

Schuster

Pfeiffer

Schulz

et al. 2017

Aging

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Cataract surgery is the most frequently performed surgical procedure worldwide. We aim to determine the prevalence of having implanted an artificial lens (pseudophakia) and of no lens (aphakia) and to compare visual function.As part of the Gutenberg Health study, a population-based cross-sectional study was conducted in Germany. An ophthalmological examination including slit-lamp examination was conducted. Prevalence including 95% confidential intervals were calculated and analyses were conducted for systemic and ocular associated factors with pseudophakia using multivariable logistic regression models. Vision-related quality of life was assessed using a standardized questionnaire and Rasch transformation.14,696 people were included. Of these, 1.55% [1.36%–1.77%] had unilateral pseudophakia and 3.08% [2.81%-3.37%] had bilateral pseudophakia. Unilateral aphakia was present in 21 people and bilateral aphakia in 2 people. Pseudophakia was independently associated with age, higher body weight and lower body height, diabetes and smoking. Vision-related quality of life values were similar for those with bilateral phakia and pseudophakia but were lower for those with unilateral pseudophakia.The pseudophakia status is related to several cardiovascular risk factors, indicating a relationship to an aging effect that causes premature lens opacification. Bilateral pseudophakia can almost imitate the physiological condition of phakia except for the need to use glasses.

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Section: Discussionmentioning

confidence: 99%

The impact of pseudophakia on vision-related quality of life in the general population – The Gutenberg Health Study

Schuster

Pfeiffer

Schulz

et al. 2017

Aging

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“…Ophthalmological examinations. The ophthalmic assessment was described in detail by Höhn et al 15 . In brief, the ophthalmic examinations included objective refraction and distance-corrected visual acuity (DCVA) (Humphrey Automated Refractor/Keratometer [HARK] 599; Carl Zeiss Meditec AG, Jena, Germany).…”

Section: Methodsmentioning

confidence: 99%

Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort

Rezapour

Schuster

Nickels

et al. 2020

Sci Rep

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to investigate the prevalence and new onset of depression and anxiety among subjects with agerelated macular degeneration (AMD) and its association with AMD in a large european cohort with relatively good visual acuity. 11,834 participants enrolled in the German population-based Gutenberg Health Study were studied. AMD was diagnosed by grading of fundus photographs. Depression and anxiety were assessed with the Patient Health Questionnaire and the Generalized Anxiety Disorder-2 Scale, respectively. Logistic regression analyses were performed and adjusted for several parameters. 1,089 (9.2%) participants were diagnosed having AMD. Prevalence of depression in AMD and non-AMD participants was 7.2% and 8.0%, respectively and prevalence of anxiety was 4.2% and 7.0%, respectively. New onset of depression and anxiety at 5-year follow-up in AMD subjects was 2.6% and 3.6%, respectively. AMD was not associated with depression (OR 0.93; CI 95% 0.70-1.20; p = 0.62). AMD was associated with less anxiety (OR 0.67; CI 95% 0.47-0.93; p = 0.02). This is the first study analyzing both prevalence and new onset of depression and anxiety in AMD subjects. AMD-and non-AMD participants had a similar prevalence and new onset of depression in our population-based sample. Participants without AMD had a higher prevalence of anxiety. AMD was not associated with depression.Age-related macular degeneration (AMD) is a chronic, progressive eye disease that leads to central visual loss due to death of photoreceptors caused by loss of retinal pigment epithelium. Advanced stages may result in geographic atrophy and/or choroidal neovascularization in the central retina. Accounting for approximately 6% of blindness worldwide, AMD is the fourth most common cause of blindness 1 .Age is one of the main risk factors for developing AMD 1 and longer life expectancy in aging populations result in an increasing number of individuals with AMD 1,2 ; an estimated 196 million individuals were affected in 2020 rising to a predicted 288 million in 2040 3 . In 2014, early and late AMD was detected in 11.9% and 0.2%, www.nature.com/scientificreports www.nature.com/scientificreports/ respectively, of individuals aged 35-74 years in Germany 4 . Treatment of "wet AMD" incorporates anti-VEGF injections that may slow down disease progression and stabilise vision 1,5 .Recently, ophthalmologists have been advised to identify and consider mental distress in those with vision loss 6 because advanced vision loss has a major impact on a person's quality of life. An inability to continue work and hobbies, and decreased mobility may adversely affect social integration and can be associated with depression. While depression is one of the leading contributors to the global disease burden, it is often accompanied by anxiety 7 . Accordingly, the prevalence of depression and anxiety in AMD patients has been subject of several studies, however reported results have been inconsistent.A European study found that poor visual acuity, but not the presence of AMD was positively associated w...

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“…A detailed description of the ophthalmological examinations is reported elsewhere 24. In brief, objective refraction and best-corrected visual acuity were measured in both eyes using a Humphrey Automated Refractor/Keratometer 599 (Carl Zeiss AG, Jena, Germany).…”

Section: Methodsmentioning

confidence: 99%

Association of low birth weight with myopic refractive error and lower visual acuity in adulthood: results from the population-based Gutenberg Health Study (GHS)

et al. 2018

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The Ophthalmic Branch of the Gutenberg Health Study: Study Design, Cohort Profile and Self-Reported Diseases

Cited by 91 publications

References 32 publications

The impact of pseudophakia on vision-related quality of life in the general population – The Gutenberg Health Study

The impact of pseudophakia on vision-related quality of life in the general population – The Gutenberg Health Study

Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort

Association of low birth weight with myopic refractive error and lower visual acuity in adulthood: results from the population-based Gutenberg Health Study (GHS)

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