The opioid effects of gluten exorphins: asymptomatic celiac disease

Pruimboom, Leo; Punder, Karin de

doi:10.1186/s41043-015-0032-y

Cited by 36 publications

(22 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Solute barrier function remains largely unchanged in NCGS, which is consistent with fairly normal adaptive immune response, normal intestinal permeability and expression of tight junction proteins[ 14 , 21 ]. Gluten’s opioid like effect on the intestinal transit time and nocebo effect has also been studied and may have an important role on the overall pathology and clinical presentation of the disease[ 31 ].…”

Section: Pathogenesismentioning

confidence: 99%

Non-celiac gluten sensitivity: All wheat attack is not celiac

Igbinedion¹,

Ansari²,

Vasikaran³

et al. 2017

WJG

View full text Add to dashboard Cite

Currently, 1% of the United States population holds a diagnosis for celiac disease (CD), however, a more recently recognized and possibly related condition, “non-celiac gluten sensitivity” (NCGS) has been suggested to affect up to 6% of the United States public. While reliable clinical tests for CD exist, diagnosing individuals affected by NCGS is still complicated by the lack of reliable biomarkers and reliance upon a broad set of intestinal and extra intestinal symptoms possibly provoked by gluten. NCGS has been proposed to exhibit an innate immune response activated by gluten and several other wheat proteins. At present, an enormous food industry has developed to supply gluten-free products (GFP) with GFP sales in 2014 approaching $1 billion, with estimations projecting sales to reach $2 billion in the year 2020. The enormous demand for GFP also reflects a popular misconception among consumers that gluten avoidance is part of a healthy lifestyle choice. Features of NCGS and other gluten related disorders (e.g., irritable bowel syndrome) call for a review of current distinctive diagnostic criteria that distinguish each, and identification of biomarkers selective or specific for NCGS. The aim of this paper is to review our current understanding of NCGS, highlighting the remaining challenges and questions which may improve its diagnosis and treatment.

show abstract

Section: Pathogenesismentioning

confidence: 99%

Non-celiac gluten sensitivity: All wheat attack is not celiac

Igbinedion¹,

Ansari²,

Vasikaran³

et al. 2017

WJG

View full text Add to dashboard Cite

show abstract

“…Second, we know that when eating wheat, the gluten exorphins stimulate insulin production and is considered an endogenous opioid activity. 30 In nonobese diabetic (NOD) mice, bred for diabetes, the incidence of T1DM is 61%. In NOD mice, bred for diabetes, never given gluten, the incidence of T1DM is 6%.…”

Section: Dr Rountree: and It Is Different For Everybody?mentioning

confidence: 99%

Food Sensitivities, Inflammation, and Autoimmune Disease: A Clinical Conversation with Tom O’Bryan, DC, CCN, DACBN, and Robert Rountree, MD

O'Bryan

Rountree²

2020

Alternative and Complementary Therapies

View full text Add to dashboard Cite

Robert Rountree: I would like to start by hearing about how you got to where you are today. What was the trajectory of your educational and professional experience? You graduated from chiropractic school in 1981. That means it has been 38 years since you got that license. You have really come a long way since then! Tom O'Bryan: I went to the University of Michigan for undergrad. I think I was 19 at the time and I first read Prevention magazine, when it was a true health magazine, before it was sold to a pharmaceutical company and began advertising the benefits of drugs for different conditions. Jonathan Wright wrote case studies every month. I would read these case studies, and he had this very down-home, earthy kind of way of explaining medical conditions to patients in language they would understand and made sense to them. I did not realize until this interview that he was my first mentor on how to effectively communicate to patients. He would talk to this guy that had a condition, what were the symptoms and all that, and he recommended nutrition and diet and the guy would come back a few months later and he was much better. The references at the back of the article gave credibility to what he was talking about and it caught my interest. I said, "My gosh, there is really something to this holistic approach, that has science to validate it." I thought that was very interesting. The world that I was really in at the time, besides my studies, was the world of aikido. I had been lucky enough that the number-two guy in the world had come to Detroit to give a demonstration. He ultimately stayed and would have three to five classes per day, and a very special once a week by invitation only class called Kenshu, for a select group of the students. This man carried the direct unfiltered lineage of > 350 years of samurai in his family. These special weekly classes were on different concepts, one per week, of the samurai code of honor called Bushido. Dr. Rountree: So those were your formative yearsduring college, when you were studying aikido? Long before you went to chiropractic school? I would imagine that introduced you to a philosophy of how to approach health care. Dr. O'Bryan: That is exactly right. From there, I then went to Japan, and I lived in the world headquarters. I was a deshi. It was such an honor. On the surface it meant that I got to clean the toilets in the school, and whatever other menial tasks were assigned to me. I spent six months there and I was privileged to visit a number of the grand masters of different disciplines, jodo and kyodo and karate. I met some very famous grand masters. Dr. Rountree: Do you still do an aikido practice today? Dr. O'Bryan: Every day as a way of life. The whole premise of aikido is that you never fight force with force, it is that you deflect and allow the force to go in the direction it wants to go. That is what really attracted me. My girlfriend at the time, who became my wife later, was in a bad car accident when she was very young, and annually or so, she would have t...

show abstract

“…Studies have shown that gluteomorphins act as opioid agonists on δ-type opioid receptors and consist of gluteomorphin A4, A5, B4, B5, C, and 7. These are resistant to the intestinal and enterobacterial proteinases, cross the human intestinal epithelium, enter the bloodstream, and interfere with the central nervous system [9,[43][44][45][46][47]. Gluteomorphin A5 has been associated with antinociceptive effect and modulation of memory process and affects peripheral nervous system and central nervous system.…”

Section: Opioid Peptides Derived From Plant/cereal Proteinmentioning

confidence: 99%

Food-Derived Opioids: Production and the Effects of Opioids on Human Health

Arısoy¹,

Çoban²,

Üstün-Aytekin³

2019

From Conventional to Innovative Approaches for Pain Treatment

View full text Add to dashboard Cite

Traditional opioids have been used for the people who suffer from cancer, burns, surgery, HIV/AIDS, and other serious illness pains for years. However, numerous side effects like dizziness, apnea, physical dependence, tolerance, addiction, nausea, and vomiting push the researchers to look forward to the new opioid options. The opioid peptides which derived from foods provide significant advantages as the safe and natural alternative. The researchers reported that it is also promising a new functional food and nutraceutical. In this chapter, the type of food-derived opioids, their origins, possible receptors, their amino acid sequences, opioid effects, production techniques, and health benefits are reviewed.

show abstract

The opioid effects of gluten exorphins: asymptomatic celiac disease

Cited by 36 publications

References 86 publications

Non-celiac gluten sensitivity: All wheat attack is not celiac

Non-celiac gluten sensitivity: All wheat attack is not celiac

Food Sensitivities, Inflammation, and Autoimmune Disease: A Clinical Conversation with Tom O’Bryan, DC, CCN, DACBN, and Robert Rountree, MD

Food-Derived Opioids: Production and the Effects of Opioids on Human Health

Contact Info

Product

Resources

About