Zoonosis calls for a multispecies approach to medical semiotics, a method involving the decipherment of outward symptoms and the construction of narrative. In Madagascar, early detection of bubonic plague outbreaks relies on sightings of sick and dead rats. However, people most vulnerable to plague often do not perceive warning signs, and plague symptoms do not always present in rat and human bodies. In August 2015, a plague outbreak killed 10 residents of a rural hamlet in the central highlands. To reconstruct the transmission chain, scientists elicited survivors' memories of dead rats in the vicinity. Not only were these clues imperceptible to most, but residents had also constructed an alternative outbreak narrative based on different evidence. Stark health disparities, a lack of historical memory of the plague, and genetic adaptations of rats and plague bacteria have created a problem of "semiotic cluelessness" that complicates outbreak control measures and increases mortality.[zoonosis, plague, multispecies ethnography, outbreak narrative, Madagascar]The bubonic plague is flourishing in Madagascar, maintaining its foothold in the black rat population and infecting people with increasing frequency and scope. Madagascar has the highest incidence of plague cases worldwide and suffered its worst outbreak in over 50 years between August and November 2017, with a total of 2,348 confirmed, probable, and suspected cases and 202 deaths (World Health Organization 2017). Over the past decade, climate change and land degradation have exacerbated the conditions of plague transmission. Climate change has impacted the movement of plague bacteria through rat, flea, and human bodies, but sorting out how it has done so remains a complex task. What is clearer is that land degradation, particularly deforestation, lures rats out of the woods toward agricultural fields and homes where rice is abundant. Scientists continue to decipher how changing rain patterns influence the reproductive patterns of rat fleas (Xenopsylla cheopis and Synopsyllus fonquerniei), the plague's main vectors in Madagascar (Ben-Ari et al. 2012; Gage and Kasov 2005).The introduction of raticide, insecticide, and antibiotics into both the sylvatic (nonhuman) cycle of the plague and its urban cycle, which includes humans, is transforming the lives of multiple species, as well as the plague bacillus,