The Optimal Axial Anatomical Site for a Single-Slice Area to Quantify the Total Volume of Visceral Adipose Tissue in Quantitative CT

Chen, Sihui; Ma, Duoshan; Su, Danyang; Li, Yali; Yu, Xiao; Jiang, Yaojun; Gao, Jianbo; Wu, Yan

doi:10.3389/fendo.2022.870552

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…If these capabilities were operationalized, radiologists could more cogently protocol patients based upon their estimated VA. An alternative to this would be to estimate the VA using a single slice through the abdomen. Several investigations have shown that one single slice can reasonably estimate the VA in patients, though there are varying opinions on which anatomic site for VA estimation is the most accurate in both the literature 25 , 26 and among our internal physicians and physicists.…”

Section: Discussionmentioning

confidence: 99%

Visceral adipose tissue volume effect in Crohn's disease using reduced exposure CT enterography

Hunter,

Baker,

Ream

et al. 2023

J Applied Clin Med Phys

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PurposeThe purpose of this investigation was to assess the effect of visceral adipose tissue volume (VA) on reader efficacy in diagnosing and characterizing small bowel Crohn's disease using lower exposure CT enterography (CTE). Secondarily, we investigated the effect of lower exposure and VA on reader diagnostic confidence.MethodsProspective paired investigation of 256 CTE, 129 with Crohn's disease, were reconstructed at 100% and simulated 50% and 30% exposure. The senior author provided the disease classification for the 129 patients with Crohn's disease. Patient VA was measured, and exams were evaluated by six readers for presence or absence of Crohn's disease and phenotype using a 0–10‐point scale. Logistic regression models assessed the effect of VA on sensitivity and specificity.ResultsThe effect of VA on sensitivity was significantly reduced at 30% exposure (odds radio [OR]: 1.00) compared to 100% exposure (OR: 1.12) (p = 0.048). There was no statistically significant difference among the exposures with respect to the effect of visceral fat on specificity (p = 0.159). The study readers’ probability of agreement with the senior author on disease classification was 60%, 56%, and 53% at 100%, 50%, and 30% exposure, respectively (p = 0.004). When detecting low severity Crohn's disease, readers’ mean sensitivity was 83%, 75%, and 74% at 100%, 50%, and 30% exposure, respectively (p = 0.002). In low severity disease, sensitivity also tended to increase as visceral fat increased (ORs per 1000 cm3 increase in visceral fat: 1.32, 1.31, and 1.18, p = 0.010, 0.016, and 0.100, at 100%, 50%, and 30% exposure).ConclusionsWhile the interaction is complex, VA plays a role in detecting and characterizing small bowel Crohn's disease when exposure is altered, particularly in low severity disease.

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Section: Discussionmentioning

confidence: 99%

Visceral adipose tissue volume effect in Crohn's disease using reduced exposure CT enterography

Hunter,

Baker,

Ream

et al. 2023

J Applied Clin Med Phys

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“…Due to their ease of use and ability to reduce radiation exposure in CT scans, techniques relying on the acquisition of a single slice are increasingly frequent used to quantify adiposity in the abdomen. [5,11,12].…”

Section: Introductionmentioning

confidence: 99%

On the relationship between CT measured abdominal fat parameters and three metabolic risk biomarkers

Pop

2023

Revista Romana De Medicina De Laborator

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Introduction: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, and there is a need for the development of adjacent markers to assess cardiovascular risk. In this study, we examined the relationship between the areas of abdominal fat compartments, as measured by computed tomography (CT)-based planar measurements, and laboratory-validated cardiovascular risk markers. Methods: Fat distribution was measured on CT scans in 252 patients (M: F = 1.13) who underwent routine abdominal CT, using in-house and commercially available software. The included laboratory parameters were glucose, triglycerides, and the triglycerideglucose index. Results: The visceral abdominal fat (VAF) area and VAF percentage were lower in females compared to the VAF area and VAF percentage in males, (p=0.001, and p<0.001 respectively). However, the total abdominal fat (TAF) area was not significantly different between genders. Visceral fat and triglyceride levels showed a weakly positive connection for females (r=0.447, p=0.002) but not for males (r=0.229, p=0.09). The glucose levels had a weak correlation with CT calculated abdominal fat parameters, with the strongest statistically significant correlation value being with TAF for females (r=0.331, p=0.003). Conclusions: Areas of abdominal fat compartments correlate with metabolic parameters in the blood, and in the future, their assessment might be considered when constructing risk scores. Visceral fat content assessment for every abdominal computed tomography procedure might become a surrogate marker for cardio-vascular risk estimation after defining clear cut-off values and image analysis parameters.

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The Optimal Axial Anatomical Site for a Single-Slice Area to Quantify the Total Volume of Visceral Adipose Tissue in Quantitative CT

Cited by 2 publications

References 31 publications

Visceral adipose tissue volume effect in Crohn's disease using reduced exposure CT enterography

Visceral adipose tissue volume effect in Crohn's disease using reduced exposure CT enterography

On the relationship between CT measured abdominal fat parameters and three metabolic risk biomarkers

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