The Optimal Flow Rate for Antegrade Cerebral Perfusion During Deep Hypothermic Circulatory Arrest

Chen, Yan; Liu, Jinping; Ji, Bingyang; Tang, Yue; Wu, Adam; Wang, Shilei; Zhou, Chun; Long, Cun

doi:10.1111/j.1525-1594.2012.01463.x

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…Continuous rSO 2 C monitoring during ACP aids the detection of cerebral perfusion abnormalities and is critical to ensuring optimal cerebral flow and adequate antegrade flow. Animal and human data demonstrate improved cerebral outcomes only if ACP flow is adequate to normalize cerebral blood flow, detectable by TCD or NIRS .…”

Section: Hypoxic Ischemic Neurologic Injurymentioning

confidence: 99%

Near‐infrared spectroscopy: exposing the dark (venous) side of the circulation

Scott

Hoffman

2013

Pediatric Anesthesia

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The safety of anesthesia has improved greatly in the past three decades. Standard perioperative monitoring, including pulse oximetry, has practically eliminated unrecognized arterial hypoxia as a cause for perioperative injury. However, most anesthesia-related cardiac arrests in children are now cardiovascular in origin, and standard monitoring is unable to detect many circulatory abnormalities. Near-infrared spectroscopy provides noninvasive continuous access to the venous side of regional circulations that can approximate organ-specific and global measures to facilitate the detection of circulatory abnormalities and drive goal-directed interventions to reduce end-organ ischemic injury.

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Section: Hypoxic Ischemic Neurologic Injurymentioning

confidence: 99%

Near‐infrared spectroscopy: exposing the dark (venous) side of the circulation

Scott

Hoffman

2013

Pediatric Anesthesia

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“…The use of DHCA in clinical practice has continued to increase in recent years. Therefore, the establishment of a simple and easy-to-use model of DHCA in vitro has been a hot topic of interest for researchers, and most of the previous animal models of in vitro circulation are large and medium-sized animals, such as rabbits, sheep, dogs, and pigs [25][26][27]. These animals have the advantage of being more anatomically similar to humans, which facilitates.…”

Section: Discussionmentioning

confidence: 99%

Organ damage evaluation in a temperature-controlled circulatory arrest rat model

Xiong

Zheng

Wang

et al. 2022

BMC Cardiovasc Disord

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Background Deep hypothermic circulatory arrest (DHCA) is commonly used in adult aortic surgery and pediatric complex congenital heart disease, and is associated with pathophysiological changes and postoperative complications. Here, a temperature-controlled circulatory arrest model in rats was established to study the suitable temperature of circulatory arrest by investigating the damage to body organs under different temperatures. Methods Thirty Sprague‒Dawley rats were randomly divided into 5 equal groups for DHCA experiments: I (15–20 °C), II (20–25 °C), III (25–30 °C), IV (normothermic cardiopulmonary bypass), and V (sham operation group). Blood gas analysis, homodynamic parameters, and intervals of cardiac recovery were measured at different time points in all groups. Morphological changes in intestinal tissue were observed under light and electron microscopes. Oxidative stress was measured by MPO activity, MDA, and SOD content. Tissue damage was confirmed by serum detection of ALT, AST, BUN, Cr, and LDH. To examine the inflammatory response, cytokines, including IL-1, IL-4, IL-10, IFN-γ, and TNF-α, were detected. Results The extracorporeal circulation technique caused damage to the body; the degree of the damage caused by the circulatory arrest technique may be related to circulating temperature, with the least amount of damage occurring at 20–25 °C compared to 15–20 °C and 25–30 °C. Ischemia and hypoxia can cause intestinal tissue damage, which manifests primarily as a loss of the intestinal mucosal barrier. Ischemic intestinal damage caused by DHCA was not associated with inflammation. Conclusion The study provides new insights into the pathophysiologic mechanisms of DHCA.

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“…Yan Chen et al. of the Peking Union Medical College, Beijing, China evaluated the optimal flow rate for antegrade cerebral perfusion (ACP) during deep hypothermia circulatory arrest (DHCA) in a piglet model. Twenty‐three piglets were randomized to five groups: the control group with no operation ( n = 3), DHCA group ( n = 5), ACP25 group ( n = 5), ACP50 group ( n = 5), and ACP80 group ( n = 5).…”

Section: Cardiopulmonary Support and Membrane Oxygenationmentioning

confidence: 99%

Artificial Organs 2012: A Year in Review

Malchesky¹

2013

Artificial Organs

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In this editor's review, articles published in 2012 are organized by category and briefly summarized. We aim to provide a brief reflection of the currently available worldwide knowledge that is intended to advance and better human life while providing insight for continued application of technologies and methods of organ replacement, recovery, and regeneration. As the official journal of the International Federation for Artificial Organs, the International Faculty for Artificial Organs, and the International Society for Rotary Blood Pumps, Artificial Organs continues in the original mission of its founders "to foster communications in the field of artificial organs on an international level." Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ replacement, recovery, and regeneration from all over the world. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide such meaningful suggestions to the author's work whether eventually accepted or rejected, and especially to those whose native tongue is not English. Without these excellent and dedicated reviewers, the quality expected from such a journal could not be possible. We also express our special thanks to our publisher, Wiley Periodicals, for their expert attention and support in the production and marketing of Artificial Organs. We look forward to recording further advances in the coming years.

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The Optimal Flow Rate for Antegrade Cerebral Perfusion During Deep Hypothermic Circulatory Arrest

Cited by 7 publications

References 13 publications

Near‐infrared spectroscopy: exposing the dark (venous) side of the circulation

Near‐infrared spectroscopy: exposing the dark (venous) side of the circulation

Organ damage evaluation in a temperature-controlled circulatory arrest rat model

Artificial Organs 2012: A Year in Review

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