The optimal shape of an aortic heart valve replacement – on the road to the consensus

Abstract

The steady increase in the number of patients with diseased aortic valves demands the development of effective aortic valve replacement procedures. Engineering and technology offer various manufactured alternatives, but none can exactly match the natural human valve. In addition to the experts of heart valve tissue engineering, many researchers focus on specific aspects of the manufacturing of artificial valves. The aim of this study was to benefit such manufacturing processes. From the contributor's perspective, it is vital to gain comprehensive knowledge before embarking on this project. The perfect/optimal shape of the valve is the fundamental aspect that needs to be considered by all participants. It is noteworthy that the geometry not only limits the functionality of the structure but also determines the choice of material and engineering methods. In this study, we attempt to determine if current knowledge is sufficient to reach consensus on the issue of the optimum shape of the valve. Here, we not only provide a brief overview of traditional literature but also include the opinions of experts. This innovative way of scientific communication is unprecedented in scientific literature, and we hope that both professionals and contributors will find this study useful.

Forming effective relationships between academia and the medical devices industry with a focus on launching a smart heart valve prosthesis for pediatric patients

“…This method of scientific communication was previously implemented in the article about the optimal shape of the HV prosthesis [2]. Since our academic research was conducted in the area of smart HV prostheses, we also contacted the main stakeholders: Abbott (IL, USA), Boston Scientific (Maple Grove, MN, USA), Medtronic (Minneapolis, MN, USA) and Edwards Lifesciences (Irvine, CA, USA).…”

“…yield functional organ growth. The concept was described in multiple scientific reports [2] and successes in the animal model were widely discussed [8][9][10]. Our added value was basing the scaffold manufacturing process on textile technology and using the advantages of the fabric architecture, which was discussed in depth elsewhere [4,7].…”

“…He was associated with several local research institutions including WCM-Q, QCRC, Sidra Hospital, and QSTP. His work has been described in multiple scientific articles [2][3][4][5][6][7] and innovation disclosures (ID). His experiences in the development of in situ engineered heart valves may be presented in the context of the scientific and business relationship in Qatar.…”

“…The corresponding author of this article is a member of the research team which focuses on developing a bioresorbable aortic heart valve (HV) prosthesis. During the last several years, a series of applicable solutions were proposed, some of which are summarized in the research articles [2][3][4][5][6][7]. Briefly, the solutions developed in the course of the research conducted in Qatar included fabrication of the smart scaffold (See Fig.…”

Preventive Effect of Albumin Nano TPA Gene Plasmid Ultrasound Microbubble Carrier System on Thrombosis after Cardiac Valve Replacement

“…Now, albumin nanoparticles are a relatively mature drug delivery system, and related drugs and diagnostic agents have been put on the market [1,2]. Albumin nanoparticles can be administered through a variety of ways, such as intravenous injection, intramuscular injection, oral administration, and intra-arterial injection [3,4]. Tissue-type plasminogen activator (tPA) is a tissue plasminogen activator that selectively activates plasmin [5,6].…”