The Oral Anticoagulants Administration in Elderly Patients with Geriatric Syndromes: What's New?

Vorobyeva, N. M.; Ткачева, О. Н.

doi:10.20996/1819-6446-2020-12-03

Cited by 2 publications

(1 citation statement)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…В этом случае ПОАК имеют преимущества перед АВК. Исследования, сравнивающие эти препараты у пациентов, которые подвержены повышенному риску падения, показали, что ПОАК (апиксабан и эдоксабан) снижают риск тяжелых кровотечений и смертности по сравнению с варфарином [11].…”

Section: особенности пожилых пациентов которые необходимо учитывать п...unclassified

Features of Elderly Patients: How to Take Them into Account When Prescribing Anticoagulant Therapy?!

Zavialov,

Gribkova

2023

A.I. Burnasyan Federal Medical Biophysical Center Clinical Bull

View full text Add to dashboard Cite

Malfunctions in the functioning of the blood coagulation system are often found in elderly patients. Age and the presence of concomitant diseases are not only risk factors for thrombosis, but also increase the likelihood of bleeding. This significantly complicates the problem of choosing anticoagulant therapy. Thus, chronic heart failure, chronic obstructive pulmonary disease, diabetes mellitus, cancer, etc. are established prothrombotic risk factors. Acquired hemophilia and von Willebrand syndrome, factor XI or vitamin K deficiency, thrombocytopenia and thrombocytopathy, on the contrary, may be risk factors for bleeding. Additional difficulties in prescribing anticoagulant therapy to elderly patients arise due to common problems in old age: renal failure, impaired liver function, polypharmacy, etc. However, the presence of these features is not a reason to refuse anticoagulant therapy, since the risk of thrombosis in such patients, as a rule, exceeds the risk of bleeding. This review details the problems that a clinician may face when prescribing anticoagulant therapy to elderly patients and provides recommendations for overcoming them. It is also reported that in the absence of contraindications, direct oral anticoagulants are the best option for the treatment of venous thromboembolic complications.

show abstract

Section: особенности пожилых пациентов которые необходимо учитывать п...unclassified

Features of Elderly Patients: How to Take Them into Account When Prescribing Anticoagulant Therapy?!

Zavialov,

Gribkova

2023

A.I. Burnasyan Federal Medical Biophysical Center Clinical Bull

View full text Add to dashboard Cite

show abstract

Study of the Anti-inflammatory Activity of 2-hydroxy-4-oxo-4-R-2-butenoates of Heterylammonium, which Have an Effect on the Blood Clotting System

Sobin,

Pulina,

Chashchina

et al. 2023

Razrabotka i registraciâ lekarstvennyh sredstv

View full text Add to dashboard Cite

Introduction. The use of anticoagulants is relevant in therapeutic, cardiological, neurological practice, geriatrics, obstetrics and gynecology, as well as in complications associated with COVID-19 infection and vaccination. In-depth studies of additional pleiotropic effects of existing anticoagulants are being conducted. The anti-inflammatory effect of heparins and direct oral anticoagulants was found. Special emphasis is placed on the existing close relationship between coagulation and inflammatory processes. The interaction of anticoagulants with nonsteroidal anti-inflammatory drugs when taken together is actively discussed. The combination of anticoagulant and anti-inflammatory action in one chemical molecule can solve the problem of polypragmasia.Aim. To study the anti-inflammatory activity of promising 2-hydroxy-4-oxo-4-R-2-butenoates of heterylammonium, which have an effect on the blood clotting system.Materials and methods. For further study of anti-inflammatory activity, 2-hydroxy-4-oxo-4-R-2-butenoates of heterylammonium, which have an effect on the blood clotting system, were selected. The anti-inflammatory effect was studied on a model of acute inflammatory edema in mongrel rats of both sexes weighing 180–250 g. The studied compounds were administered intragastrically. Diclofenac sodium and nimesulide substances administered similarly were used as comparison drugs. Acute toxicity of substances that showed activity was studied on white nonlinear mice of both sexes weighing 18–22 g with the definition of LD50.Results and discussion. All the studied 2-hydroxy-4-oxo-4-R-2-butenoates of heterylammonium have anti-inflammatory effects of varying severity. Data on the study of acute toxicity during intragastric administration, allow us to attribute the studied compounds to the 4.5 class of the hazard classification of chemical products.Conclusion. The anti-inflammatory activity of 14 2-hydroxy-4-oxo-4-R2-butenoates of heterylammonium has been studied. Five butanoate have an effect lower than comparison drugs, eight compounds are comparable to the effect of reference drugs, one compound is superior to nimesulide. The studied compounds can be assigned to class 4,5 of the hazard classification of chemical products. Medicinal candidates have been selected for further pharmacological, toxicological and technological study.

show abstract

The Oral Anticoagulants Administration in Elderly Patients with Geriatric Syndromes: What's New?

Cited by 2 publications

References 53 publications

Features of Elderly Patients: How to Take Them into Account When Prescribing Anticoagulant Therapy?!

Features of Elderly Patients: How to Take Them into Account When Prescribing Anticoagulant Therapy?!

Study of the Anti-inflammatory Activity of 2-hydroxy-4-oxo-4-R-2-butenoates of Heterylammonium, which Have an Effect on the Blood Clotting System

Contact Info

Product

Resources

About