The oral component of Sjögren's syndrome

Daniels, T.; Silverman, S; Michalski, Joseph P.; Greenspan, John S.; Sylvester, Robert A.; Talal, Norman

doi:10.1016/0030-4220(75)90108-5

Cited by 188 publications

(86 citation statements)

References 21 publications

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“…The results from these clinical and postmortem studies, from the present study and from our own experience (7), indicate that an LSG biopsy focus score >1 focusl4 mm2 is an effective threshold for diagnosis of the salivary component of SS. LSG specimens with focus scores equal to 1 should be considered transitional values suggesting the possibility of SS, and scores of < I , or specimens with nonfocal inflammation, should be considered as within normal limits or as nonspecific inflammation.…”

Section: Discussionsupporting

confidence: 59%

“…The reason patients' complaints of xerostomia often do not correlate with PFR measurements is that symptoms of xerostomia are frequently caused by reduction only of resting salivary flow (e.g., from drug side effects), but the glands retain normal secretory capacity under stimulated PFR conditioiis. However, a reduced stimulated salivary flow rate is still a nonspecific event with diverse causes (l), and even in SS, normal flow rates are occasionally seen in patients with moderately severe disease (7,8).…”

Section: Discussionmentioning

confidence: 99%

“…cal and laboratory examinations directed toward the diagnoses of connective tissue disease, keratoconjunctivitis sicca (9), and inflammatory salivary gland disease (7). LSG biopsy was performed if a patient's history excluded drug side effects or therapeutic irradiation as causes of chronic xerostomia, and if examination revealed any of the following: oral mucosal or dental signs of chronic xerostomia (1,7), reduced parotid flow rate (7), chronic or recurrent enlargement of major salivary glands (2,7), abnormal salivary scintigraphy (lo), the presence of systemic and/or ocular components of SS without oral symptoms or signs, or a clinical need to rule out SS.…”

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confidence: 99%

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Labial salivary gland biopsy in sjögren's syndrome

Daniels

1984

Arthritis & Rheumatism

501

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Xerostomia is an unsatisfactory diagnostic criterion for the salivary component of Sjögren's syndrome (SS). To determine the diagnostic usefulness of the presence of focal sialadenitis in labial salivary gland (LSG) biopsy specimens, 362 patients suspected of having SS prospectively underwent a unique LSG biopsy procedure. The pattern and severity of LSG inflammation were compared with measurements of parotid flow rate, and the presence or absence of symptomatic xerostomia, major salivary gland enlargement, keratoconjunctivitis sicca (KCS), and other connective tissue diseases (CTD). LSG biopsy focus scores of >1 correlated more closely with the diagnoses of KCS alone and with KCS plus a CTD than did either reduced parotid flow rate or symptoms of xerostomia (P < 0.0005 and P < 0.05, respectively). Focal sialadenitis in an adequate LSG specimen is an objective criterion and a more disease‐specific feature of SS than xerostomia or any other feature of salivary disease. The salivary component of SS should be redefined as the presence of LSG focal sialadenitis.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Labial salivary gland biopsy in sjögren's syndrome

Daniels

1984

Arthritis & Rheumatism

501

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“…The presence of keratoconjunctivitis sicca was based on positive staining with Rose-Bengal and decreased Schirmer test (10). Xerostomia was confirmed by labial salivary gland biopsy and parotid flow rate (11,12). The diagnoses of rheumatoid arthritis and SLE were made by standard diagnostic criteria (13,14).…”

Section: Methodsmentioning

confidence: 99%

Decreased autologous mixed lymphocyte reaction in Sjögren's syndrome.

Miyasaka¹,

Sauvezie²,

Pierce³

et al. 1980

J. Clin. Invest.

138

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“…Focal sialadenitis of grade IV (lo), which corresponds to a lymphocytic focus score > 1 focusl4 mm2 of SSG tissue, is a widely accepted criterion for the histologic confirmation of the diagnosis of SS (1)(2)(3)(4)(5)(6)(7)(8)(9). However, this criterion results in 6 9 % falsepositive diagnoses in a normal population (1 1,12), and 1840% of patients with clinically diagnosed SS have a lymphocytic focus score of 11 (9,10,(13)(14)(15).…”

mentioning

confidence: 99%

A new and highly sensitive immunohistologic diagnostic criterion for Sjögren's syndrome

Wilde

Kater

Baak

et al. 1989

Arthritis & Rheumatism

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Immunohistologic investigation of the sublabial salivary glands of 65 surgical patients who were free of systemic disease (control) and 19 patients with Sjogren's syndrome resulted in a new diagnostic criterion for SS that was more disease-specific than the widely used lymphocytic focus wore criterion. Our bivariate classification criterion, which is based on the percentages of IgA-and IgG-containing plasma cells, has a specificity of 95.4% and a sensitivity of loo%, while its overall percentage of misclassification is 3.6%. This immunohistologic diagnostic criterion results in a reduction of the percentage of false-positive diagnoses from 9% to 4.6%.Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by the clinical manifestations of xerostomia and keratoconjunctivitis sicca (KCS) related to lymphocytic infiltration and dysfunction of the salivary and lacrimal glands (1-7). SS has

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The oral component of Sjögren's syndrome

Cited by 188 publications

References 21 publications

Labial salivary gland biopsy in sjögren's syndrome

Labial salivary gland biopsy in sjögren's syndrome

Decreased autologous mixed lymphocyte reaction in Sjögren's syndrome.

A new and highly sensitive immunohistologic diagnostic criterion for Sjögren's syndrome

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