The oral management of patients who have received radiotherapy to the head and neck region

Ray-Chaudhuri, Arijit; Shah, Kanchan; Porter, Richard

doi:10.1038/sj.bdj.2013.380

Cited by 56 publications

(32 citation statements)

References 30 publications

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“…In detail, telangiectasia and fibrosis occur as late skin side effects, and therapy-associated cardiovascular disease from breast carcinoma patients performed breast-conserving surgery followed by radiotherapy [28] ; [29]. Sophisticated oral sequelae, such as mucositis and salivary hypofunction, occur following radiotherapy toward head and neck cancer [30] ; [31]. Radiotherapy-induced bowel/bladder toxicity affects the life quality of patients with prostate cancer [32].…”

Section: Discussionmentioning

confidence: 99%

Total abdominal irradiation exposure impairs cognitive function involving miR-34a-5p/BDNF axis

Cui¹,

Xiao²,

Li³

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Radiotherapy is often employed to treat abdominal and pelvic malignancies, but is frequently accompanied by diverse acute and chronic local injuries. It was previously unknown whether abdominal and pelvic radiotherapy impairs distant cognitive dysfunction. In the present study, we demonstrated that total abdominal irradiation (TAI) exposure caused cognitive deficits in mouse models. Mechanically, microarray assay analysis revealed that TAI elevated the expression level of miR-34a-5p in small intestine tissues and peripheral blood (PD), which targeted the 3′UTR of Brain-derived neurotrophic factor (Bdnf) mRNA in hippocampus to mediate cognitive dysfunction. Tail intravenous injection of miR-34a-5p antagomir immediately after TAI exposure rescued TAI-mediated cognitive impairment via blocking the up-regulation of miR-34a-5p in PD, resulting in restoring the Bdnf expression in the hippocampus. More importantly, high throughput sequencing validated that the gut bacterial composition of mice was shifted after TAI exposure, which was retained by miR-34a-5p antagomir injection. Thus, 27(7):916-932our findings provide new insights into pathogenic mechanism underlying abdominal and pelvic radiotherapy-mediated distant cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

Total abdominal irradiation exposure impairs cognitive function involving miR-34a-5p/BDNF axis

Cui¹,

Xiao²,

Li³

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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“…Globally, approximately 670,000 new diagnoses of head and neck cancer (HNC) and 350,000 HNC-related deaths are reported every year ( Ray-Chaudhuri, Shah & Porter, 2013 ). HNC is the sixth most common cancer in Taiwan and the fourth most common among Taiwanese men ( Chang et al, 2017a ).…”

Section: Introductionmentioning

confidence: 99%

Effects of income and residential area on survival of patients with head and neck cancers following radiotherapy: working age individuals in Taiwan

Lai

Tang

Chu

et al. 2018

PeerJ

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ObjectivesThe five-year survival rate of head and neck cancer (HNC) after radiotherapy (RT) varies widely from 35% to 89%. Many studies have addressed the effect of socioeconomic status and urban dwelling on the survival of HNC, but a limited number of studies have focused on the survival rate of HNC patients after RT.Materials and methodsDuring the period of 2000–2013, 40,985 working age individuals (20 < age < 65 years) with HNC patients treated with RT were included in this study from a registry of patients with catastrophic illnesses maintained by the Taiwan National Health Insurance Research Database (NHIRD).ResultsThe cumulative survival rate of HNC following RT in Taiwan was 53.2% (mean follow-up period, 3.75 ± 3.31 years). The combined effects of income and geographic effect on cumulative survival rates were as follows: high income group > medium income group > low income group and northern > central > southern > eastern Taiwan. Patients with moderate income levels had a 36.9% higher risk of mortality as compared with patients with high income levels (hazard ratio (HR) = 1.369; p < 0.001). Patients with low income levels had a 51.4% greater risk of mortality than patients with high income levels (HR = 1.514, p < 0.001).ConclusionIn Taiwan, income and residential area significantly affected the survival rate of HNC patients receiving RT. The highest income level group had the best survival rate, regardless of the geographic area. The difference in survival between the low and high income groups was still pronounced in more deprived areas.

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“…Dental attention for HNC patients is essential and must be incorporated in each stage of the oncologic process. This process has different and independent stages where it is important to control the potential complications that can occur in the oral cavity after chemotherapy and radiotherapy (9)(10)(11). Potential toxicities and affected structures by chemotherapy, radiotherapy and/or surgery are summarized on Table 1.…”

Section: Dental Care For Hnc Patientsmentioning

confidence: 99%

The Multidisciplinary Team (MDT) Approach and Quality of Care

et al. 2020

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The core function of a multidisciplinary team (MDT) is to bring together a group of healthcare professionals from different fields in order to determine patients' treatment plan. Most of head and neck cancer (HNC) units are currently led by MDTs that at least include ENT and maxillofacial surgeons, radiation and medical oncologists. HNC often compromise relevant structures of the upper aerodigestive tract involving functions such as speech, swallowing and breathing, among others. The impairment of these functions can significantly impact patients' quality of life and psychosocial status, and highlights the crucial role of specialized nurses, dietitians, psycho-oncologists, social workers, and onco-geriatricians, among others. Hence, these professionals should be integrated in HNC MDTs. In addition, involving translational research teams should also be considered, as it will help reducing the existing gap between basic research and the daily clinical practice. The aim of this comprehensive review is to assess the role of the different supportive disciplines integrated in an MDT and how they help providing a better care to HNC patients during diagnosis, treatment and follow up.

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The oral management of patients who have received radiotherapy to the head and neck region

Cited by 56 publications

References 30 publications

Total abdominal irradiation exposure impairs cognitive function involving miR-34a-5p/BDNF axis

Total abdominal irradiation exposure impairs cognitive function involving miR-34a-5p/BDNF axis

Effects of income and residential area on survival of patients with head and neck cancers following radiotherapy: working age individuals in Taiwan

The Multidisciplinary Team (MDT) Approach and Quality of Care

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