The oral manifestations and related mechanisms of COVID-19 caused by SARS-CoV-2 infection

Lin, Wei-Ming; Gao, Feng; Wang, Xia; Qin, Nianhong; Chen, Xianxiong; Tam, Kin Yip; Zhang, Chengfei; Zhang, Mingxia; Sha, Ou

doi:10.3389/fncel.2022.1006977

Cited by 13 publications

(5 citation statements)

References 96 publications

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“…In this study, the common oral problems in cases infected with SARS-CoV-2 were similar to the results of Lin et al [4] The oral symptoms of "positive" infected persons are mainly concentrated in abnormal taste, gingiva red swelling or bleeding, toothache and bad breath. The development of their oral symptoms is signi cantly related to the different demographic characteristics and different living habits of the population.…”

Section: Discussionsupporting

confidence: 89%

“…The most common symptoms of oral cavity are taste disorder, dry mouth and oral mucous membrane lesions. [4] As more and more research reports on the oral symptoms of COVID-19 patients reveal oral problems after infection, for example, periodontitis. [5][6][7] Salivary gland in ammation,[8] oral candidiasis, [9] oral ulcer, [10] oral herpes, [11] oral lichen planus, [12] "novel coronavirus tongue".…”

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confidence: 99%

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Oral status of outpatients in Suining Central Hospital in post-epidemic era

Gao,

王,

Guo

et al. 2023

Preprint

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Background To investigate the oral status of COVID-19 positive groups in Suining City under the comprehensive implementation of epidemic prevention and control, analyze the prognostic characteristics and related influencing factors, and understand the residual symptoms after recovery from COVID-19 infection in the post-epidemic era, so as to provide reference for the treatment of patients in the post-epidemic era.Methods Based on a 25-question online questionnaire survey, the oral status and prognosis of COVID-19 positive groups in Suining City were reviewed after the comprehensive implementation of epidemic prevention and control measures.Results 1768 valid questionnaires were collected. The data showed that 363 people had oral problems after an infection with novel coronavirus. The oral problems after SARS-CoV‐2 infection mainly focused on gingiva swelling or bleeding (38.57%), toothache (37.74%), oral ulcer (30.30%), bad breath (27.55%), abnormal taste (24.24%) and some infected people had a variety of oral symptoms. A small number of infected people also showed dry mouth, herpes around the mouth, maxillofacial swelling, tongue pain and numbness, dry lip peeling, oral lichen planus, tongue coating black, tongue coating thick white oral symptoms. The incidence of oral symptoms was significantly correlated with sex, age, educational level, place of residence, smoking, basic diseases, long-term saline gargle and vaccination of COVID-19 vaccine. In addition, the age, place of residence, smoking history, basic diseases, and vaccination also showed significant differences in prognosis.Conclusion In the post-epidemic era, the most common oral problems are gingiva swelling or bleeding, toothache, bad breath, oral ulcer, and abnormal taste. And maintaining good living habits is the basis for promoting disease recovery and oral health.

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

Oral status of outpatients in Suining Central Hospital in post-epidemic era

Gao,

王,

Guo

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In this study, the common oral problems in cases infected with SARS-CoV-2 were similar to the results of Lin et al (4) The oral symptoms of "positive" infected persons are mainly concentrated in abnormal taste, gingiva red swelling or bleeding, toothache and bad breath. The development of their oral symptoms is significantly related to the different demographic characteristics and different living habits of the population.…”

Section: Discussionsupporting

confidence: 89%

Oral manifestations and prognosis of COVID-19 positive population in Suining City in the post-epidemic era

Gao,

Wang,

Guo

et al. 2023

Preprint

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Objectives: To investigate the oral symptoms of COVID-19 ’s “positive” group in Suining City after the comprehensive liberalization of epidemic prevention and control measures in China. To explore the related influencing factors of symptom differences and provide reference for the treatment of patients in the post-epidemic era. Methods: An online survey based on a random sample of 25 questions. Results: 1768 valid questionnaires were collected. The data showed that 363 people had oral problems after an infection with novel coronavirus. The oral problems after SARS‐CoV‐2 infection mainly focused on gingiva swelling or bleeding (38.57%), toothache (37.74%), bad breath (27.55%), oral ulcer (30.30%), abnormal taste (24.24%) and some infected people had a variety of oral symptoms. A small number of infected people also have other oral problems. The incidence of oral symptoms was significantly correlated with sex, age, educational level, place of residence, smoking, basic diseases, long-term saline gargle and vaccination of COVID-19 vaccine. In addition, the age, place of residence, smoking history, basic diseases, and vaccination also showed significant differences in prognosis. Conclusions: In the post-epidemic era, the most common oral problems are gingiva swelling or bleeding, toothache, bad breath, oral ulcer, and abnormal taste. And maintaining good living habits is the basis for promoting disease recovery and oral health.

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“…This can be explained by the SARS-CoV-2 invasion of entry taste papillae cells, resulting in cellular harm and leading to the clinical symptom of dysgeusia [78]. In the mucous membrane of the tongue, immunohistochemistry studies showed ACE2 expression within the cell cytoplasm and across the cellular membrane within the non-keratinized area, alongside TMPRSS2 positioning specifically on the cellular membrane [79,80]. ACE2 was detected in minor quantities within the lamina propria of non-keratinized stratified squamous epithelia in mucosal structures.…”

Section: Tonguementioning

confidence: 99%

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

Bellocchio,

Dipalma,

Inchingolo

et al. 2023

Biomedicines

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission are generally known to be produced by respiratory droplets and aerosols from the oral cavity (O.C.) of infected subjects, as stated by the World Health Organization. Saliva also retains the viral particles and aids in the spread of COVID-19. Angiotensin-converting enzyme Type 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are two of the numerous factors that promote SARS-CoV-2 infection, expressed by O.C. structures, various mucosa types, and the epithelia of salivary glands. A systemic SARS-CoV-2 infection might result from viral replication in O.C. cells. On the other hand, cellular damage of different subtypes in the O.C. might be associated with various clinical signs and symptoms. Factors interfering with SARS-CoV-2 infection potential might represent fertile ground for possible local pharmacotherapeutic interventions, which may confine SARS-CoV-2 virus entry and transmission in the O.C., finally representing a way to reduce COVID-19 incidence and severity.

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The oral manifestations and related mechanisms of COVID-19 caused by SARS-CoV-2 infection

Cited by 13 publications

References 96 publications

Oral status of outpatients in Suining Central Hospital in post-epidemic era

Oral status of outpatients in Suining Central Hospital in post-epidemic era

Oral manifestations and prognosis of COVID-19 positive population in Suining City in the post-epidemic era

COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

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