The oral-systemic disease connection: a retrospective study

Joseph, Bobby; Kullman, Leif

doi:10.1007/s00784-016-1725-3

Cited by 17 publications

(12 citation statements)

References 25 publications

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“…In the oral cavity, caries (World Health Organization [WHO] 2015) and periodontal diseases (World Dental Federation 2013) are examples of noncommunicable diseases (NCDs). A consistent relationship has shown between these oral diseases and other NCDs (Hujoel 2009; Joseph et al 2016; Kesim et al 2016). Obesity has been associated with caries (WHO 2015) and periodontal diseases (Keller et al 2015).…”

Section: Introductionsupporting

confidence: 70%

Added Sugar Consumption and Chronic Oral Disease Burden among Adolescents in Brazil

et al. 2018

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Chronic oral diseases are rarely studied together, especially with an emphasis on their common risk factors. This study examined the association of added sugar consumption on "chronic oral disease burden" among adolescents, with consideration of obesity and systemic inflammation pathways through structural equation modeling. A cross-sectional study was conducted of a complex random sample of adolescent students enrolled at public schools in São Luís, Brazil ( n = 405). The outcome was chronic oral disease burden, a latent variable based on the presence of probing depth ≥4 mm, bleeding on probing, caries, and clinical consequences of untreated caries. The following hypotheses were tested: 1) caries and periodontal diseases among adolescents are correlated with each other; 2) added sugar consumption and obesity are associated with chronic oral disease burden; and 3) chronic oral disease burden is linked to systemic inflammation. Models were adjusted for socioeconomic status, added sugar consumption, oral hygiene behaviors, obesity, and serum levels of interleukin 6 (IL-6). All estimators of the latent variable chronic oral disease burden involved factor loadings ≥0.5 and P values <0.001, indicating good fit. Added sugar consumption (standardized coefficient [SC] = 0.212, P = 0.005), high IL-6 levels (SC = 0.130, P = 0.036), and low socioeconomic status (SC = -0.279, P = 0.001) were associated with increased chronic oral disease burden values. Obesity was associated with high IL-6 levels (SC = 0.232, P = 0.001). Visible plaque index was correlated with chronic oral disease burden (SC = 0.381, P < 0.001). Our finding that caries and periodontal diseases are associated with each other and with added sugar consumption, obesity, and systemic inflammation reinforces the guidance of the World Health Organization that any approach intended to prevent noncommunicable diseases should be directed toward common risk factors.

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Section: Introductionsupporting

confidence: 70%

Added Sugar Consumption and Chronic Oral Disease Burden among Adolescents in Brazil

et al. 2018

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“…The relationship between oral and systemic diseases/conditions has been examined and is well documented; consequently, in recent years the relationship between physical frailty and oral hypofunction (deterioration of oral function) has also been examined, in various epidemiological studies. For example, it has been reported that sarcopenia, one of the core components of physical frailty, is associated with decline in occlusal force and mastication efficiency, with a significant odds ratio; there are also sex differences in the relationship .…”

Section: Introductionmentioning

confidence: 99%

Assessment of potential clinical cascade between oral hypofunction and physical frailty: Covariance structure analysis in a cross‐sectional study

Hihara

Goto

Ichikawa

2019

J of Oral Rehabilitation

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No report has yet examined the impact of oral hypofunction on physical frailty in relation to intra‐relationships of physical frailty assessment items. The purpose of this study was to verify the potential of a clinical cascade between oral hypofunction and physical frailty, and especially to support the hypothesis that the influence of oral hypofunction on physical frailty is greater than the intra‐relationships among elements of physical frailty and that sex differences significantly affect these relationships. The participants were 272 older adults (101 men and 171 women; mean age 75.1 ± 7.5 years). Maximum occlusal force (MOF) and oral dryness (OD), as indicators of oral hypofunction, and grip strength (GS) and walking speed (WS), as indicators of physical frailty, were measured. Mutual relationship of four variables was verified using covariance structure analysis. In men, three paths from MOF to WS and GS and from WS to GS were confirmed, and those from MOF to WS and from WS to GS were found to be significant (P < .01). In women, three paths from MOF to WS and GS and from WS to GS were also confirmed, as with the men, and those from MOF to WS and from MOF to GS were found to be significant (P < .01). Model adaptability was shown to be good for both men and women. The results suggest our hypothesis was verified, and it is expected that the early detection of oral hypofunction, that is MOF, may be important for assessing physical frailty, especially in women.

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“…Nowadays, these oral diseases cannot be used as a standard to measure oral health completely, because it ignores the multi-level characteristics of oral health and other impacts on quality of life [11]. For these reasons, that have prompted many researchers to examine the relationship between oral health and general health [12][13][14][15]. The correlation between oral health and general health has been proved by evidence, which is also mentioned in the World Health Organization report 2003 [10,16].…”

Section: Introductionmentioning

confidence: 99%

Oral health diseases among the older people: a general health perspective

2020

JOMH

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Background: The relationship between oral health and general health is gaining interest in geriatric research; however, a lack of studies dealing with this issue from a general perspective makes it somewhat inaccessible to non-clinical public health professionals. Purpose: The purpose of this review is to describe the relationship between oral health and general health of the elderly on the basis of literature review, and to give non-clinical medical professionals and public health professionals an overview of this discipline. Methods: This study was based on an in-depth review of the literature pertaining to the relationship between oral health and general health among the older people. The tools commonly used to evaluate dental health and the academic researches of male elderly people were also reviewed. And future research directions were summarized. Results: Dental caries, periodontal disease, edentulism, and xerostomia are common oral diseases among the older people. Dental caries and periodontal diseases are the leading causes of missing teeth and edentulism. Xerostomia, similar to dry mouth, is another common oral health disease in the older people. No clear correlation exists between the subjective feeling of dryness and an objective decrease of saliva. Rather, both conditions can be explained by changes in saliva. The General Oral Health Assessment Index (GOHAI) and the Oral Health Impact Proﬁle (OHIP) are the main assessment tools used to examine oral health and quality of life in the older people. The GOHAI tends to be more sensitive to objective values pertaining to oral function. In addition, oral health studies in male elderly people are population-based cohort or cross-sectional studies, involving masticatory function, oral prevention, frailty problems, cardiovascular disease risk, and cognitive status. Conclusion: It is possible to reduce the incidence of certain oral diseases, even among individuals who take oral health care seriously. Oral health care should be based on the viewpoint of comprehensive treatment, including adequate nutrition, good life and psychology, and correct oral health care methods. In the future, researchers could combine the results of meta-analysis with the clinical experience of doctors to provide a more in-depth and broader discussion on oral health research topics concerning the older people.

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The oral-systemic disease connection: a retrospective study

Abstract: The significance of the oral-systemic disease connection highlights the importance of preventing and treating oral disease which have profound medical implications on general health.

Cited by 17 publications

References 25 publications

Added Sugar Consumption and Chronic Oral Disease Burden among Adolescents in Brazil

Added Sugar Consumption and Chronic Oral Disease Burden among Adolescents in Brazil

Assessment of potential clinical cascade between oral hypofunction and physical frailty: Covariance structure analysis in a cross‐sectional study

Oral health diseases among the older people: a general health perspective

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