THE ORAL TOXICITY FOR SHEEP OF TRITERPENE ACIDS ISOLATED FROM <i>LANTANA CAMARA</i>

Seawright, A. A.; Hrdlicka, J.

doi:10.1111/j.1751-0813.1977.tb00195.x

Cited by 35 publications

(12 citation statements)

References 18 publications

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“…The phytochemical analysis of the leaf extract by qualitative method showed the presence of triterpenoids and flavanoids and the absence of other constituents. This observation was similar to that reported by Seawright and Hrdlicka (1977) for the presence of triterpene acids such as lantadene A, reduced lantadene A and lantadene B. Flavonoids are excellent antioxidants and free radical scavengers. There is a controversy over the role of free radicals on wound healing (Juranek and Bezek, 2005).…”

Section: Discussionsupporting

confidence: 91%

Evaluation of wound healing activity of Lantana camara L. – a Preclinical study

Nayak¹,

Raju²,

Eversley³

et al. 2008

Phytotherapy Research

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Lantana camara is used in herbal medicine for the treatment of skin itches, as an antiseptic for wounds, and externally for leprosy and scabies. The objective of our study was to investigate excision wound healing activity of the leaf extract of L. camara in rats. The animals were divided into two groups of 12 each in both the models. The test group animals were treated with the aqueous extract of L. camara (100 mg/kg/day) topically and the control group animals were left untreated. Wound healing efficacy was measured by determining the morphological and biochemical parameters. Wound healing time, wound contraction and synthesis of collagen were monitored periodically. Antimicrobial activities of the extract against the microorganisms were also assessed. Treatment of the wounds with extract enhanced significantly the rate of wound contraction (98%), synthesis of collagen and decreased mean wound healing time. These studies demonstrate that L. camara is effective in healing excision wounds in the experimental animal and could be evaluated as a therapeutic agent in tissue repair processes associated with skin injuries.

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Section: Discussionsupporting

confidence: 91%

Evaluation of wound healing activity of Lantana camara L. – a Preclinical study

Nayak¹,

Raju²,

Eversley³

et al. 2008

Phytotherapy Research

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“…The flow of ingesta into the small intestine decreases markedly a few hours after dosing with lantana (Pass, McSweeney & Reynoldson, 1981) and this corresponds to the onset of ruminal stasis. It had been proposed that lantana toxins caused gastrointestinal stasis by paralysing the muscle of the gut (Rimington et al 1937;Seawright, 1965). The response of the reticulum and rumen to stimulation of the vagus nerves in intoxicated sheep indicated that the muscle was able to contract and that a direct action of the toxins on the muscle is unlikely to be the cause of ruminal stasis.…”

Section: Discussionmentioning

confidence: 99%

“…The first was a 20 % Cremophor EL (Sigma) in saline solution containing lantadene A (10 mg/ml) given as a 5 ml bolus. Lantadene A is the major toxin in lantana plants (Hart, Lamberton, Sioumis & Suares, 1976;Seawright & Hrdlicka, 1977;Pass, Seawright, Lamberton & Heath, 1979). Cremophor EL was used to solubilize lantadene A.…”

Section: Effect Of Infusing Lantana Toxins Into a Carotid Arterymentioning

confidence: 99%

The Mechanism of Ruminal Stasis in Lantana‐poisoned Sheep

McSweeney

Pass

1983

Exp Physiol

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SUMMARYThe effect of poisoning by the plant Lantana camara L. on reticulo-ruminal motility was investigated in sheep. There was a marked decrease in forestomach motility 4-6 h after dosing with the plant and motility continued to be depressed throughout the course of the disease. The effect of lantana on motility was characterized by a decrease in the number and median amplitude of forestomach movements. This was in contrast to the effect of starvation which caused a decrease in only the number of forestomach movements and even this effect was less severe than in lantana-poisoned animals. The effects of lantana on the components of the reflex which controls rumen motility were examined. No evidence was found for a direct effect of lantana toxins on the stretch and tactile receptors in the reticulum; on the vagus nerves; on the gastric centre or on the muscle of the forestomach. However, evidence was found to support an hypothesis that stasis of the rumen in lantana poisoning is due to inhibitory influences arising from the damaged liver. The evidence included a correlation between the onset of ruminal stasis and liver injury; a relationship between the severity of liver injury and ruminal stasis and the finding that denervation of the liver converted the pattern of forestomach movements in intoxicated animals to that seen in starved animals. It is concluded that stasis of the rumen in lantana-poisoned animals is due at least initially, to inhibitory neural impulses arising from the damaged liver and to the effects of anorexia.

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“…Hematological examination in cattle reveals, increase in blood clotting time and hematocrit values but decrease in erythrocyte sedimentation rate has been reported (Hussain & Roychoudhury, 1992). There was an increase in direct and total bilirubin, increase in the phylloerythrin levels, increase in serum AST, ALP, GLDH, serum total protein, serum albumin, and serum globulin and decrease in albumin/globulin ratio in cattle (Dwivedi et al, 1971;Seawright & Hrdlicka, 1977). The fibrous tissue formation is seen in chronic liver conditions irrespective of etiology, as in chronic diseases the myofibroblasts produce type 1 collagen which leads to fibrosis.…”

Section: Bmentioning

confidence: 99%

Lantana camara: An alien weed, its impact on animal health and strategies to control

Kumar¹,

Katiyar²,

Kumar³

et al. 2016

JEBAS

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KEYWORDS Lantana camara Lantadenes Allelopathy Hepatotoxic Poisonous ABSTRACTLantana camara is one of the most commonly known noxious weed distributed worldwide. The red flower variety (L. camara var. aculeata) of this weed is mainly toxic and usually prevalent in tropical and sub-tropical countries. Lantana leads to hepatotoxicity, photosensitization and intrahepatic cholestasis almost in all the animals. LA is the main toxic pentacyclic triterpenoid present in this weed. Lantadene toxicity leads to fatty degeneration, bile duct hyperplasia, gall bladder edema, degeneration of parenchymal cells and portal fibrosis observed on histopathological examination. L. camara toxicity causes fluctuation in hematological as well as in biochemical parameters. The management of toxic effects can be achieved by activated charcoal, vaccination and supportive therapy but are not much effective. Besides the harmful effects of this plant, there are some beneficial effects also including antiinflammatory, hepatoprotective action, antitumor action etc. The control of this weed is difficult because of its allelopathic action. Nowadays this plant is used in many recent advanced techniques like phytoremediation of particulate pollution, phytoextraction of heavy metals and many others. Thereby the use of this plant in the field of research can be an effective way to manage this alien weed. As far as the toxicity is concerned it can be prevented by the using conventional therapeutic methods along with immunological, nanotechnological and biotechnological approaches. The aim of this article is to discuss the information regarding its progression, mechanism by which it affect animals, pathological alterations, treatment and what strategies we can opt to get rid of this weed.

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THE ORAL TOXICITY FOR SHEEP OF TRITERPENE ACIDS ISOLATED FROM LANTANA CAMARA

Cited by 35 publications

References 18 publications

Evaluation of wound healing activity of Lantana camara L. – a Preclinical study

Evaluation of wound healing activity of Lantana camara L. – a Preclinical study

The Mechanism of Ruminal Stasis in Lantana‐poisoned Sheep

Lantana camara: An alien weed, its impact on animal health and strategies to control

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