We prove an asymptotic expansion of the second moment of the central values of the GL(n) × GL(n) Rankin-Selberg L-functions L(1/2, π ⊗ π 0 ), for a fixed cuspidal automorphic representation π 0 , over the family of π with analytic conductors bounded by a quantity which is tending off to infinity. Our proof uses the integral representations of the L-functions, period with regularized Eisenstein series, and the invariance properties of the analytic newvectors.