The organisation of spinal projecting brainstem neurons in an animal model of muscular dystrophy

Carretta, Donatella; Santarelli, Marialaura; Vanni, Duccio; Carrai, Riccardo; Sbriccoli, Alessandro; Pinto, Fausto J.; Minciacchi, Diego

doi:10.1016/s0006-8993(01)02108-4

Cited by 28 publications

(24 citation statements)

References 49 publications

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“…The red nucleus (ReN), vestibular nuclear complex (VNC), medullary reticular formation (MRF), and raphe nuclei (RaN) were defined according to the same criteria used in our previous paper on brainstem and spinal projections of mdx mice (Carretta et al, 2001). In particular, the ReN is considered a unitary group disregarding the subdivision in caudal magnocellular and rostral parvocellular portions (Reid et al, 1975).…”

Section: Regional Delimitation and Data Acquisitionmentioning

confidence: 99%

“…This is according to the format of data we previously adopted in a recent study of the mdx brainstem (Carretta et al, 2001) and in consideration of the readability and nature of results we obtained in the present experiments.…”

Section: Brainstemmentioning

confidence: 99%

“…In particular, our survey of spinal descending pathways revealed a dramatic loss of corticospinal and rubrospinal neurons Carretta et al, 2001). To further characterize brain changes in mdx mice and obtain clues on pathologic events occurring in the dystrophin-deficient brain, we investigated the pattern of neurons that contain calcium-binding proteins (CBPs) in the cortex and brainstem of these animals.…”

mentioning

confidence: 99%

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Cortical and brainstem neurons containing calcium‐binding proteins in a murine model of Duchenne's muscular dystrophy: Selective changes in the sensorimotor cortex

Carretta

Santarelli²,

Vanni

et al. 2002

J of Comparative Neurology

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In the muscular dystrophic (mdx) mouse, which is characterized by deficient dystrophin expression and provides a model of Duchenne's muscular dystrophy, we previously demonstrated marked central nervous system alterations and in particular a quantitative reduction of corticospinal and rubrospinal neurons and pathologic changes of these cells. Prompted by these findings and in view of the relations between calcium ions and dystrophin, we analyzed with immunohistochemistry the neurons containing the calcium-binding proteins parvalbumin, calbindin D28k, and calretinin in cortical areas and brainstem nuclei of mdx mice. In the sensorimotor cortex, parvalbumin-positive and calbindin-positive neurons, which represent a subset of cortical interneurons, were significantly more numerous in mdx mice than in wild-type ones. In addition, the laminar distribution of parvalbumin-positive neurons in the motor and somatosensory cortical areas of mdx mice was altered with respect to wild-type animals. No alterations in the number and distribution were found in the parvalbumin- or calbindin-expressing cell populations of the visual and anterior cingulate cortices of mdx mice. The pattern of calretinin immunoreactivity was normal in all investigated cortical areas. The cell populations containing either calcium-binding protein were similar in brainstem nuclei of mdx and wild-type mice. The present findings demonstrated selective changes of subsets of interneurons in the motor and somatosensory cortical areas of mdx mice. Therefore, the data showed that, in the cortices of these mutant animals, the previously demonstrated pathologic changes of corticospinal cell populations are accompanied by marked alterations in the local circuitry.

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Section: Regional Delimitation and Data Acquisitionmentioning

confidence: 99%

Section: Brainstemmentioning

confidence: 99%

mentioning

confidence: 99%

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Cortical and brainstem neurons containing calcium‐binding proteins in a murine model of Duchenne's muscular dystrophy: Selective changes in the sensorimotor cortex

Carretta

Santarelli²,

Vanni

et al. 2002

J of Comparative Neurology

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“…In the central nervous system, it may modulate synaptic terminal integrity, synaptic plasticity, and regional cellular signal-intensity integration. 7 Studies on the mdx mouse found dramatic loss of corticospinal neurons 8,9 due to dystrophin deficiency.…”

mentioning

confidence: 99%

Decreased Gray Matter Concentration and Local Synchronization of Spontaneous Activity in the Motor Cortex in Duchenne Muscular Dystrophy

Zou

Cui

et al. 2011

AJNR Am J Neuroradiol

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“…At the cellular/axonal level dystrophin has been found to localise to the cell membrane, predominately the soma and postsynaptic densities particularly in hippocampus, neocortex, cerebellum and amygdale (Anderson et al 2002;Lidov 1996;. Anatomical alterations have been found in the mdx mouse in various brain regions including decreased cell number, altered cell packing density and changes in cell morphology (Carretta et al 2001;Sbriccoli et al 1995). It should be noted that these changes were not demonstrated when investigated in the hippocampus.…”

Section: Morphologymentioning

confidence: 99%

Duchenne Muscular Dystrophy and Brain Function

Anderson¹,

Head²,

Morley³

2012

Muscular Dystrophy

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The organisation of spinal projecting brainstem neurons in an animal model of muscular dystrophy

Cited by 28 publications

References 49 publications

Cortical and brainstem neurons containing calcium‐binding proteins in a murine model of Duchenne's muscular dystrophy: Selective changes in the sensorimotor cortex

Cortical and brainstem neurons containing calcium‐binding proteins in a murine model of Duchenne's muscular dystrophy: Selective changes in the sensorimotor cortex

Decreased Gray Matter Concentration and Local Synchronization of Spontaneous Activity in the Motor Cortex in Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy and Brain Function

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