ABSTRACT. Background. Unsolicited electronic mail (e-mail) is e-mail sent to a physician from a person unknown to the physician, who is seeking professional help. The purpose of this project was to analyze unsolicited e-mails sent to a digital textbook author to: 1) characterize the e-mails, 2) determine what resources would be necessary to answer the e-mails, and 3) propose a standard approach to reply to e-mails in a helpful yet medicolegally-responsive manner.Materials and Methods. All e-mails (315) sent to a digital textbook author from October 1995 through October 1998 were abstracted. Variables included: date and location, sender type, patient age, subject, medical content, and resources necessary to answer the question. Data frequencies were obtained.Results. The most common location was the .com domain (47.6%). The most common senders were laypersons (66%). Overall, 44.4% of the e-mails concerned children. Detailed, patient-specific information was sent in 63.2% of the e-mails. The most common subjects were overviews of a disease or problem (32.4%), differential diagnosis (16.8%), and therapy/treatment questions (15.9%). The medical content covered a broad range of specialties. Specialists were overwhelmingly the resource necessary to answer the e-mails (74.9%).Conclusions. Pediatricians with educational information on the Internet can expect an increase in the number of unsolicited e-mails as Internet usage expands. Laypersons regard even short passages to mean the author is an expert in that particular area. Pediatricians need to consider the ethical and medicolegal implications of responding to unsolicited e-mails. A nonpersonalized, standard e-mail reply is proposed that directs the sender to quality information resources that may be of further assistance. Pediatrics 2000;105(6). URL: http://www. pediatrics.org/cgi/content/full/105/6/e74; unsolicited electronic mail, e-mail, medical informatics, legal issues, ethical issues, digital libraries.ABBREVIATION. e-mail, electronic mail. E lectronic mail (e-mail) is a revolutionary new way for pediatricians to communicate with their patients about their care. E-mail offers numerous advantages, including its asynchronous nature, which allows the convenience of replying when one chooses; easy clarification of meaning or instructions; and retention of the interaction, especially information conveyed, which would need to be referenced in the future. Disadvantages of e-mail include: again, its asynchronous nature leading to a variable delay between message receipt and reply, the inability to document that the message has been received and reviewed, and concerns about privacy. Recently, the American Medical Informatics Association Internet Working Group put forth guidelines to help physicians with the clinical use of e-mail with their own patients that are now being widely recommended and adopted.1 However, these guidelines did not comment on the standards that physicians should follow when unknown patients approach them for professional help via e-mail on the In...