The origin of forebrain afferents to the habenula in rat, cat and monkey

Parent, André; Gravel, Samuel Bergeron; Boucher, R.

doi:10.1016/s0361-9230(81)80066-4

Cited by 112 publications

(78 citation statements)

References 46 publications

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“…In agreement with a previous report (Marburg, 1944), and consistent with findings in rats and other mammals (i.e., Parent et al, 1981;Paxinos and Watson, 1998;Andres et al, 1999;Jones, 2006;Mikula et al, 2007), our analysis confirmed that the human HbCpx can be subdivided into MHb and LHb, each containing a large degree of intranuclear morphologic heterogeneity. Furthermore, systematic analysis of serially stained sections using a combination of morphologic and immunohistochemical criteria revealed intranuclear boundaries that allowed the distinction of five subnuclei in both the MHb and LHb.…”

Section: Discussionsupporting

confidence: 93%

“…Given the paucity of hodological approaches in primates, and the absence of connectional data in humans, the examination of which afferent nuclei contributes primarily to the enlarged SM and LHb of humans is rather speculative. A comparative study describing the relative contribution of several limbic and striatal afferents to the LHb reveals that in rats the major source of afferents is the entopeduncular nucleus followed by the lateral hypothalamus and lateral preoptic area, whereas in cats and squirrel monkeys the main source of afferents is the lateral hypothalamus, with additional contributions from septal nuclei and part of the internal segment of the globus pallidus (Parent et al, 1981). It is important to notice that, as in humans, the LHb of the rhesus monkey (Macaca mulatta) shows a relative enlargement of its dorsal domain, which coincides with the region where afferent fibers enter the HbCpx (Mikula et al, 2007).…”

Section: Relative Enlargement Of the Lhb In Humansmentioning

confidence: 99%

“…The MHb is formed by a densely packed array of cells, which in the rat organizes into five distinct subnuclei according to cytoarchitectonic and ultrastructural criteria (Andres et al, 1999), and include substance P-positive and cholinergic neurons segregated into dorsal and ventral domains, respectively (Contestabile et al, 1987;Kawaja et al, 1990). The MHb receives afferents primarily from the limbic forebrain, particularly the posterior septum (Herkenham and Nauta, 1977;Parent et al, 1981) and projects through the core of the FR to the interpeduncular nucleus (IPN), which in turn projects to the ventral and dorsolateral tegmental nuclei as well as the median raphe nucleus (Herkenham and Nauta, 1979). The MHb has been suggested to play a role in stress responses (Sugama et al, 2002) and analgesia (Plenge et al, 2002), its input to the IPN has been linked to the neural control of sleep (Haun et al, 1992), and is vulnerable to the neurotoxic effects of addictive drugs such as nicotine (Carlson et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Morphologic and immunohistochemical organization of the human habenular complex

Díaz

Bravo

Rojas

et al. 2011

J of Comparative Neurology

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The habenular complex (HbCpx) is a phylogenetically conserved brain structure located in the epithalamus of vertebrates. Despite its fundamental role in decision-making processes and the proposed link between habenular dysfunction and neuropsychiatric conditions, little is known about the structural and functional organization of the HbCpx in humans. The goal of this study was thus to provide a first systematic morphologic and immunohistochemical analysis of the human HbCpx to begin dissecting its nuclear and subnuclear organization. Our results confirmed that the human HbCpx is subdivided into medial (MHb) and lateral (LHb) nuclei, each showing a large degree of intranuclear morphologic heterogeneity. Analysis of serially stained sections using a combination of morphologic and immunohistochemical criteria allowed the distinction of five subnuclei in both the MHb and LHb. Overall, the observed subnuclear organization of the MHb in humans resembles the organization of subnuclei in the MHb of rats. The shape, relative size, and intranuclear organization of the LHb, however, show significant differences. The contribution of the LHb to the entire HbCpx is about five times larger in humans than in rats. Noteworthy, a dorsal domain of the LHb that contains afferent myelinated fibers from the stria medullaris and shows GABA-(B) -R(1) immunoreactive cells, appears substantially enlarged in humans when compared to rats. This feature seems to account for a large part of the relative growth in size of the LHb in humans and opens the intriguing possibility of an increased influence of limbic and striatal afferents into the LHb of humans.

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Section: Discussionsupporting

confidence: 93%

Section: Relative Enlargement Of the Lhb In Humansmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Morphologic and immunohistochemical organization of the human habenular complex

Díaz

Bravo

Rojas

et al. 2011

J of Comparative Neurology

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“…This is a unique projection, in that the dorsal pallidum does not seem to project ventrally. Parts of the VP (along with the dorsal pallidum) project to the LHb, a structure now considered to be part of the reward circuit (Matsumoto and Hikosaka, 2007;Morissette and Boye, 2008;Ullsperger and von Cramon, 2003); Haber et al, 1993 #554;Parent, 1981 #12010 (see section below for a discussion of the habenular nucleus). Finally, part of the VP (as with the external segment of the pallidum) also projects to the striatum (Spooren et al, 1996).…”

Section: Ventral Pallidum (Figure 8)mentioning

confidence: 99%

“…There are several possible routes by which the LHb might influence midbrain dopamine firing. In addition to an input from the globus pallidus and VP, other connections include the basal forebrain, preoptic area of hypothalamus, interpeduncular nucleus, pedunculopontine nucleus, raphe nucleus, superior colliculus, pretectal area, central gray, VTA, and reticular formation (Araki et al, 1988;Haber et al, 1993;Herkenham and Nauta, 1977;Parent et al, 1981).…”

Section: Thalamusmentioning

confidence: 99%

The Reward Circuit: Linking Primate Anatomy and Human Imaging

Haber

Knutson

2009

Neuropsychopharmacol

3,183

193

2,859

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Although cells in many brain regions respond to reward, the cortical-basal ganglia circuit is at the heart of the reward system. The key structures in this network are the anterior cingulate cortex, the orbital prefrontal cortex, the ventral striatum, the ventral pallidum, and the midbrain dopamine neurons. In addition, other structures, including the dorsal prefrontal cortex, amygdala, hippocampus, thalamus, and lateral habenular nucleus, and specific brainstem structures such as the pedunculopontine nucleus, and the raphe nucleus, are key components in regulating the reward circuit. Connectivity between these areas forms a complex neural network that mediates different aspects of reward processing. Advances in neuroimaging techniques allow better spatial and temporal resolution. These studies now demonstrate that human functional and structural imaging results map increasingly close to primate anatomy.

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Afferent and efferent connections of the habenula in the rainbow trout (Oncorhynchus mykiss): An indocarbocyanine dye (DiI) study

Yáñez

Anadón

1996

J. Comp. Neurol.

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The habenula is a conserved structure in the brain of vertebrates. With the aim of further understanding of the evolution of the habenular system in vertebrates, we studied the afferent and efferent connections of the habenula of the rainbow trout. Experiments included application of the carbocyanine dye 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI) into the habenula, telencephalon, pineal organ, posterior tubercle, and interpeduncular nucleus (IPN). The results obtained reveal a consistent pattern of habenular connections. Most afferents originate from three nuclei, one extending from the preoptic region to the rostral thalamus (the entopeduncular nucleus), the second located in the region of the hypothalamus-posterior tubercle and consisting of large bipolar cells (tuberculohabenular nucleus), and the third in the preoptic region (preoptic nucleus). A few large neurons of the locus coeruleus appeared to be labeled in some cases. The trout habenula also receives pineal and parapineal projections. Small labeled glial cells were observed in the thalamus around the fasciculus retroflexus and, sometimes, around the IPN. The most conspicuous efferents coursed in the fasciculus retroflexus to the IPN, the isthmal raphe, and the central gray. The existence of olfactohabenular or habenulotelencephalic projections is discussed.

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The origin of forebrain afferents to the habenula in rat, cat and monkey

Cited by 112 publications

References 46 publications

Morphologic and immunohistochemical organization of the human habenular complex

Morphologic and immunohistochemical organization of the human habenular complex

The Reward Circuit: Linking Primate Anatomy and Human Imaging

Afferent and efferent connections of the habenula in the rainbow trout (Oncorhynchus mykiss): An indocarbocyanine dye (DiI) study

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