The origin of Langerhans’ cell from the melanocyte

Shukla, Rishabh

doi:10.1159/000143306

Cited by 1 publication

(1 citation statement)

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“…He assumed that the amelanotic melanocyte population provides DOPA-positive dendritic melanocytes that migrate into, and fill, the epidermis for follicular repigmentation. However, these amelanotic melanocytes were not always clearly distinguished from Langerhans progenitors because of the lack of specific lineage markers available at the time (Shukla, 1969;Staricco, 1963). Ortonne et al examined the unpigmented skin of vitiligo patients after treatment with UV therapy using scanning electron microscopy and DOPA staining.…”

Section: Human 'Amelanotic Melanocytes' Versus Mouse Hair Germ Melanomentioning

confidence: 99%

Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation

Nishimura

2011

Pigment Cell Melanoma Res

273

262

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Most mammals are coated with pigmented hair. Melanocytes in each hair follicle produce melanin pigments for the hair during each hair cycle. The key to understanding the mechanism of cyclic melanin production is the melanocyte stem cell (MelSC) population, previously known as 'amelanotic melanocytes'. The MelSCs directly adhere to hair follicle stem cells, the niche cells for MelSCs and reside in the hair follicle bulge-subbulge area, the lower permanent portion of the hair follicle, to serve as a melanocyte reservoir for skin and hair pigmentation. MelSCs form a stem cell system within individual hair follicles and provide a 'hair pigmentary unit' for each cycle of hair pigmentation. This review focuses on the identification of MelSCs and their characteristics and explains the importance of the MelSC population in the mechanisms of hair pigmentation, hair greying, and skin repigmentation.

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Section: Human 'Amelanotic Melanocytes' Versus Mouse Hair Germ Melanomentioning

confidence: 99%