The origin of the corpus callosum and the fate of the structures related to it

Abbie, A. A.

doi:10.1002/cne.900700103

Cited by 68 publications

(32 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CC is the largest axon bundle that connects many areas between the two hemispheres, including the inferior frontal lobes, deeper limbic structures, supplementary motor cortices and cingulate gyri (Abbie, 1940). Early callosal axons originating from the cingulate cortex (cingulate cortex-originated axons) pioneer and cross the midline of the telencephalon during E15.5-E16.5, and late arriving collaterals of the CC that originate from other regions of the neocortex (neocortex-originated axons) follow the pre-existing axon tract, and join to form the typical U-shaped axonal tract (Koester and O'Leary, 1994;Ozaki and Wahlsten, 1998;Rash and Richards, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…The second telencephalic commissure, AC, comprises of two major axon pathways; the anterior limb that connects the anterior olfactory nucleus and anterior piriform cortex, and the posterior limb that connects the piriform and temporal cortices (Abbie, 1940). The early extension of the AC in jsap1 +/+ was clearly detected and appeared to cross the midline at E14.5.…”

Section: Temporal Patterns Of Developmental Defects Of the Telencephamentioning

confidence: 99%

See 1 more Smart Citation

JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains

Cho

Lee

et al. 2011

Exp Mol Med

View full text Add to dashboard Cite

We previously reported that mice lacking JSAP1 (jsap1 -/-) were lethal and the brain of jsap1 -/-at E18.5 exhibited multiple types of developmental defects, which included impaired axon projection of the corpus callosum and anterior commissures. In the current study, we examined whether the early telencephalic commissures were formed abnormally from the beginning of initial development or whether they arose normally, but have been progressively lost their maintenance in the absence of JSAP1. The early corpus callosum in the brain of jsap1 +/+ at E15.5-E16.5 was found to cross the midline with forming a distinct U-shaped tract, whereas the early axonal tract in jsap1 -/-appeared to cross the midline in a diffuse manner, but the lately arriving axons did not cross the midline. In the brain of jsap1 -/-at E17.5, the axon terminals of lately arriving collaterals remained within each hemisphere, forming an early Probst's bundle-like shape. The early anterior commissure in the brain of jsap1 +/+ at E14.5-E15.5 crossed the midline, whereas the anterior commissure in jsap1 -/-developed, but was deviated from their normal path before approaching the midline. The axon tracts of the corpus callosum and anterior commissure in the brain of jsap1 -/-at E16.5-E17.5 expressed phosphorylated forms of FAK and JNK, however, their expression levels in the axonal tracts were reduced compared to the respective controls in jsap1. Considering the known scaffolding function of JSAP1 for the FAK and JNK pathways, these results suggest that JSAP1 is required for the pathfinding of the developing telencephalic commissures in the early brains.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Temporal Patterns Of Developmental Defects Of the Telencephamentioning

confidence: 99%

JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains

Cho

Lee

et al. 2011

Exp Mol Med

View full text Add to dashboard Cite

show abstract

“…Moreover, a few major vertebrate axon tracts have appeared with no apparent precursors. The most dramatic example is the (dorsal) corpus callosum, which is found only in placental mammals (15,16).The corpus callosum is a large interhemispheric commissure, and most axons of the corpus callosum interconnect homotopic neocortical areas (17)(18)(19)(20)(21)(22). for exceptions to this general rule.)…”

mentioning

confidence: 99%

“…for exceptions to this general rule.) Monotremes and marsupials have no dorsal corpus callosum (2,16,(26)(27)(28). Among the placental mammals, the corpus callosum generally increases as the neocortex increases (16).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Ontophyletics of the nervous system: development of the corpus callosum and evolution of axon tracts.

Katz¹,

Lasek²,

Silver³

1983

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The evolution of nervous systems has included significant changes in the axon tracts of the central nervous system. These evolutionary changes required changes in axonal growth in embryos. During development, many axons reach their targets by following guidance cues that are organized as pathways in the embryonic substrate, and the overall pattern of the major axon tracts in the adult can be traced back to the fundamental pattern of such substrate pathways. Embryological and comparative anatomical studies suggest that most axon tracts, such as the anterior commissure, have evolved by the modified use of preexisting substrate pathways. On the other hand, recent developmental studies suggest that a few entirely new substrate pathways have arisen during evolution; these apparently provided opportunities for the formation of completely new axon tracts. The corpus callosum, which is found only in placental mammals, may be such a truly new axon tract. We propose that the evolution of the corpus callosum is founded on the emergence of a new preaxonal substrate pathway, the "glial sling," which bridges the two halves of the embryonic forebrain only in placental mammals.Increases in the number of central nervous system (CNS) neurons and in the complexity of the synaptic neuropil characterize the vertebrate phylogeny (1, 2). These increases are usually manifest as enlargements of specific CNS areas such as the cerebellum, the tectum, and the cerebrum. Local enlargements can be attributed to focal increases in the dominant class of vertebrate neurons-local circuit neurons-neurons with axons that extend only short distances in the CNS before synapsing (1).Local areas of the CNS are connected by another important class of neurons-projection neurons-which send their axons along a few long stereotyped routes to target areas far from their cell bodies. The white matter of the vertebrate CNS is composed largely of axon tracts of projection neurons, and many of the same major axon tracts can be identified throughout the vertebrates. Although the overall pattern of these major tracts appears to have been conserved during evolution (2-8), there are some significant variations. Frequently, the compactness of particular tracts varies, as in the spinal lemniscal tracts (2, 9-11). In some cases, the particular stereotyped route taken by homologous axons varies-e.g., the stereotyped routes of the corticospinal tracts differ among most primates, ungulates, rodents, and marsupials (12-14). Moreover, a few major vertebrate axon tracts have appeared with no apparent precursors. The most dramatic example is the (dorsal) corpus callosum, which is found only in placental mammals (15,16).The corpus callosum is a large interhemispheric commissure, and most axons of the corpus callosum interconnect homotopic neocortical areas (17)(18)(19)(20)(21)(22). for exceptions to this general rule.) Monotremes and marsupials have no dorsal corpus callosum (2,16,(26)(27)(28). Among the placental mammals, the corpus callosum generally increases as t...

show abstract

Molecular regulation of the developing commissural plate

Moldrich

Gobius

Pollak

et al. 2010

J of Comparative Neurology

View full text Add to dashboard Cite

Coordinated transfer of information between the brain hemispheres is essential for function and occurs via three axonal commissures in the telencephalon: the corpus callosum (CC), hippocampal commissure (HC) and anterior commissure (AC). Commissural malformations occur in over 50 human congenital syndromes causing mild to severe cognitive impairment. Disruption of multiple commissures in some syndromes suggests that common mechanisms may underpin their development. Diffusion tensor magnetic resonance imaging revealed that forebrain commissures crossed the midline in a highly specific manner within an oblique plane of tissue, referred to as the commissural plate. This specific anatomical positioning suggests that correct patterning of the commissural plate may influence forebrain commissure formation. No analysis of the molecular specification of the commissural plate has been performed in any species, therefore we utilized specific transcription factor markers to delineate the commissural plate, and identify its various sub-domains. We found that the mouse commissural plate consists of four domains, and tested the hypothesis that disruption of these domains might affect commissure formation. Disruption of the dorsal domains occurred in strains with commissural defects such as Emx2 and Nfia knockout mice but commissural plate patterning was normal in other acallosal strains such as Satb2. Finally, we demonstrate an essential role for the morphogen, Fgf8 in establishing the commissural plate at later developmental stages. The results demonstrate that correct patterning of the commissural plate is an important mechanism in forebrain commissure formation.

show abstract

The origin of the corpus callosum and the fate of the structures related to it

Cited by 68 publications

References 5 publications

JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains

JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains

Ontophyletics of the nervous system: development of the corpus callosum and evolution of axon tracts.

Molecular regulation of the developing commissural plate

Contact Info

Product

Resources

About