The Origin(s) of Cell(s): Pre-Darwinian Evolution from FUCAs to LUCA

Tang, Shiping

doi:10.1007/s00239-021-10014-4

Cited by 1 publication

(3 citation statements)

References 201 publications

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“…There is a high correlation between protein/peptide structural dynamics and evolution . Protein/peptide structural dynamics are subjected to thermal noises, which can trigger functional motions .…”

Section: Discussionmentioning

confidence: 99%

“…31 Protein/peptide structural dynamics are subjected to thermal noises, which can trigger functional motions. 31 Occasionally, newly produced peptides with complex structures would be capable of performing with high substrate specificities or novel functions in Sammoxdriven CRNs. The catalytic capabilities of Sammox-driven CRNs as a whole can thus increase because an increasing number of 14 N-peptides with high substrate specificities and/or novel functions selectively survive (Figure 6).…”

Section: Isotope Effects and Prebiotic Evolution In Sammox-drivenmentioning

confidence: 99%

“…There is a high correlation between protein/peptide structural dynamics and evolution. 31 Protein/peptide structural dynamics are subjected to thermal noises, which can trigger functional motions. 31 Occasionally, newly produced peptides with complex structures would be capable of performing with high substrate specificities or novel functions in Sammoxdriven CRNs.…”

Section: Isotope Effects and Prebiotic Evolution In Sammox-drivenmentioning

confidence: 99%

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Demonstrating Prebiotic Peptide Evolution by Nitrogen Isotope Discrimination in an Autocatalytic Chemical Reaction Network

Bao,

Wu,

et al. 2024

ACS Earth Space Chem.

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Nitrogen isotope discrimination may be closely related to the prebiotic evolution of peptides that occurred in the origin of life from chemical reaction networks (CRNs). We deduce that autocatalytic Sammox (sulfurous reduction coupled to anaerobic ammonium oxidation)-driven CRN is a feasible scenario for life origin. To demonstrate prebiotic peptide evolution, we investigated N isotope discrimination in proteinogenic amino acids and peptide synthesis in Sammox-driven CRNs, combining mathematical and physical models. The species and amounts of proteinogenic amino acids generated in Sammox-driven CRNs with 14 NH 4 + as the N source were all significantly higher than those in Sammox-driven CRNs with 15 NH 4 + as the N source for both hydrothermal and microaerobic eutectic freezing conditions. The low yield of 15 N-amino acids, both species and amounts, will lead to the formation of 15 N-peptides with poor structure and function and slow peptide dynamics; these peptides might be preferentially degraded in Sammox-driven CRNs. We then explored the nitrogen isotopic effects during the synthesis process from ammonia to glycine, from glycine to glycine-containing peptides, and during the process of glycine-containing peptide hydrolysis. 15 N are eliminated in competition with 14 N during the process of glycine synthesis, glycine-containing peptide synthesis, and glycinecontaining peptide hydrolysis under hydrothermal conditions as determined by the maximum entropy production principle, which is a prebiotic evolution process. In addition, pyrrole as the building block of the prosthetic group, which is generated from Sammoxdriven CRNs under hydrothermal conditions, may provide a more evolutionary possibility of prebiotic peptides.

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Section: Discussionmentioning

confidence: 99%

Section: Isotope Effects and Prebiotic Evolution In Sammox-drivenmentioning

confidence: 99%