“…Through all of antiquity and, aside from Swedenborg's work, the seventeenth century, the cortex enjoyed scant interest (Karenberg, 2009). For Descartes, it was the firm yet mobile pineal gland where the soul, the immaterial mind, inseparable from consciousness and thought, had its most immediate association with the mechanistic body (Lokhorst and Kaitaro, 2001). For him, this structure, awash in 'psychic spirits', was 'the part of the brain in which the soul executes all of its principal operations' and where it is most immediately affected 'only by the brain' (Descartes, in Lokhorst and Kaitaro, 2001, pp.…”