2006
DOI: 10.1016/j.jpain.2006.04.010
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The Orofacial Formalin Test in the Mouse: A Behavioral Model for Studying Physiology and Modulation of Trigeminal Nociception

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Cited by 125 publications
(104 citation statements)
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“…The orofacial formalin test is a very useful method for to evaluate antinociceptive drugs, and to elucidate its action mechanism (Luccarini et al, 2006). During the test, two phases can at least partially distinct mechanisms of nociception.…”
Section: Discussionmentioning
confidence: 99%
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“…The orofacial formalin test is a very useful method for to evaluate antinociceptive drugs, and to elucidate its action mechanism (Luccarini et al, 2006). During the test, two phases can at least partially distinct mechanisms of nociception.…”
Section: Discussionmentioning
confidence: 99%
“…The first phase is associated to direct stimulation of C-nociceptors, whereas the second phase reflects integration between peripheral (nociceptors) and central (spinal/ brainstem) signaling Capuano et al, 2009). Furthermore, it has been reported that the development of hyperalgesia due to injection of formalin involves glutamatergic system, such as N-methyl-D-aspartate (NMDA) receptors (Beirith et al, 2002;Luccarini et al, 2006). Pretreatment with LEO or LIN were able to block both phases of the formalin response.…”
Section: Discussionmentioning
confidence: 99%
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“…The induction of nociception in the orofacial formalin test was done by subcutaneous injection of formalin (20 μL, 2%) into the upper lip of mice (n=8/ group) according to previous studies (Luccarini et al, 2006). The administration of formalin in the orofacial region induces a biphasic behavioral response (Cadet et al, 1993).…”
Section: Formalin Testmentioning
confidence: 99%