The orthogonal electrocardiogram in normal women. Implications of sex differences in diagnostic electrocardiography

Nemati, Massoud; Doyle, Joseph T.; McCaughan, Donald; Dunn, Rosalie A.; Pipberger, Hubert V.

doi:10.1016/0002-8703(78)90393-9

Cited by 40 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[37][38][39][40][41][42][43][44] This finding is probably due to the relatively larger body and heart sizes in males compared with females. 37,38,45 In summary, using ECG we found that SV 1 +R(V 5 ,V 6 ) was correlated with BP at the first clinic visit in both males and females. SV 1 +R(V 5 ,V 6 ) was associated with Cr in males with LVH.…”

Section: Discussionmentioning

confidence: 98%

Plasma renin activity could be a useful predictor of left ventricular hypertrophy in essential hypertensives

et al. 1998

View full text Add to dashboard Cite

To clarify the ability of clinical and laboratory parameters to reflect target organ damage, especially left ventricular hypertrophy (LVH), we investigated which of these parameters might correlate to LVH as determined by electrocardiographic voltage at the first clinic visit in 108 (53 males and 55 females, average age 52 ± 10 years) untreated essential hypertensives. The sum of the amplitude of the S wave in lead V 1 plus that of the R wave in lead V 5 or V 6 (SV 1 + R(V 5 , V 6 )) was correlated

show abstract

Section: Discussionmentioning

confidence: 98%

Plasma renin activity could be a useful predictor of left ventricular hypertrophy in essential hypertensives

et al. 1998

View full text Add to dashboard Cite

show abstract

“…Analogous observations were made in previous scalar orthogonal lead ECG studies in which intersex time-normalized repolarization voltages were compared at successive 1/8 time divisions of the JT interval. 12,13 More recently, Macfarlane 20 found men to have greater average ST angles, as measured between the J point and 3/8 of the JT interval (P.W. Macfarlane, PhD, personal communication, 1999), in selected conventional ECG leads.…”

Section: Discussionmentioning

confidence: 99%

“…3,4,9 -11 These studies, however, did not correct for variations in heart rate (HR), a deficiency that other researchers attempted to remedy by reliance on a JT-normalized time scale. [12][13][14] Thus, to date, a systematic comparison of the ST-T voltage trajectory and its dynamics, as a true function of time, in men and women has not been accomplished.…”

mentioning

confidence: 99%

Sexual Dimorphism in the Electrocardiographic Dynamics of Human Ventricular Repolarization

Lehmann

Yang

2001

Circulation

View full text Add to dashboard Cite

Background-Previous characterizations of sex differences in ST-T waveform voltages have largely focused on amplitudes at selected time points during repolarization, subject to potential distortions from variations in heart rate (HR) or reliance on a JT-normalized time scale. Methods and Results-Using digitized 12-lead ECGs from 553 normal adults (426 males) with HRs confined to 60Ϯ1, 70Ϯ1, or 80Ϯ1 bpm, we derived X, Y, and Z lead voltages and then generated, for each HR category by sex, summary (population mean) resultant spatial vector amplitudes (ST-T XYZ ) and instantaneous slopes (dV/dt XYZ ) at successive 4-ms intervals following the J point. Within each HR category, there was an early intersex divergence of ST-T XYZ trajectories (95% CIs nonoverlapping), with men exhibiting 2-to 3-fold greater dV/dt XYZ values during the ST segment and achieving greater maximum T XYZ and dV/dt XYZ values than women; descending T XYZ limbs were relatively more concordant between sexes but still steeper in men. The early sex differences in repolarization dynamics persisted in multiple regression analyses that took into account age and a morphometric index of left ventricular mass. In men, absolute values of extrema of T XYZ and dV/dt XYZ varied inversely with HR. Conclusions-At physiological resting HRs, the spatial ST-T vector voltage time trajectory is steeper in men than in women, beginning virtually from the J point. In addition to its mechanistic implications, the demonstration of marked sensitivity of ST-T XYZ and especially dV/dt XYZ to sex raises the possibility that these time-based, ECG-derived parameters might be informative in pathophysiological studies of ventricular repolarization.

show abstract

“…Gender‐related differences in cardiovascular diseases have become an increasingly crucial area of research in cardiology. Compared to men, women are more likely to have nonischemic cardiomyopathy and a narrower QRS duration associated with bundle branch block patterns . Women are also less likely to have atrial fibrillation, prior coronary revascularization, or renal dysfunction in comparison to men, which have been identified as adverse clinical predictors of response to cardiac resynchronization therapy (CRT‐D) .…”

Section: Introductionmentioning

confidence: 99%

“…Compared to men, women are more likely to have nonischemic cardiomyopathy and a narrower QRS duration associated with bundle branch block patterns. 1,2 Women are also less likely to have atrial fibrillation, prior coronary revascularization, or renal dysfunction in comparison to men, which have been identified as adverse clinical predictors of response to cardiac resynchronization therapy (CRT-D). [3][4][5] These differences may help to explain differences in success rates and adverse events related to cardiac device implantation.…”

Section: Introductionmentioning

confidence: 99%

Early Procedure‐Related Adverse Events by Gender in MADIT‐CRT

Jamerson

McNitt

Polonsky

et al. 2014

Cardiovasc electrophysiol

View full text Add to dashboard Cite

show abstract

The orthogonal electrocardiogram in normal women. Implications of sex differences in diagnostic electrocardiography

Cited by 40 publications

References 27 publications

Plasma renin activity could be a useful predictor of left ventricular hypertrophy in essential hypertensives

Plasma renin activity could be a useful predictor of left ventricular hypertrophy in essential hypertensives

Sexual Dimorphism in the Electrocardiographic Dynamics of Human Ventricular Repolarization

Early Procedure‐Related Adverse Events by Gender in MADIT‐CRT

Contact Info

Product

Resources

About