The Oslo Balloon Angioplasty versus Conservative Treatment Study (OBACT)—The 2-years Results of a Single Centre, Prospective, Randomised Study in Patients with Intermittent Claudication

Abstract

The advantage of conducting a single centre study and adhering to very strict inclusion criteria was illustrated by the homogenous demographic data of the two groups. This partly outweighed the disadvantage of having included a relatively small number of patients. Early intervention with PTA in addition to OMT seems to have a generally more positive effect compared to OMT only, on haemodynamic, functional as well as QoL aspects during the first 2 years in patients with IC.

Early Outcomes From a Randomized, Controlled Trial of Supervised Exercise, Angioplasty, and Combined Therapy in Intermittent Claudication

“…However, none of the included studies directly compared SEP and PTA. [17][18][19][20][21][22][23][24] There is no published literature of a three-way comparison between SEP, PTA, and SEP + PTA; thus, this study is the first of its kind.…”

Systematic review of exercise training or percutaneous transluminal angioplasty for intermittent claudication

“…Two trials compared PTA plus ET advice with ET advice alone 15,16,19,20 , four compared PTA with SET 13,18,22 -24 , two compared PTA plus SET with SET 21,24 and two compared PTA plus SET with PTA 24,25 ( Table 4). Table 5 summarizes the diverse exercise programmes varying from home-based exercise without supervision 15,16,19,20 to SET programmes 13,18,21 -25 .…”

“…Table 5 summarizes the diverse exercise programmes varying from home-based exercise without supervision 15,16,19,20 to SET programmes 13,18,21 -25 . The exercise programme included dynamic leg exercises 13 , exercise advice 15,16,19,20 , a walking circuit 21 , an exercise circuit 18,24 and treadmill training 22,23,25 . In four trials, the intervention covered both PTA with, or without selective stent placement 19 -23,25 ; the other trials referred to PTA alone.…”

Improved Quality of Life After 1 Year With an Invasive Versus a Noninvasive Treatment Strategy in Claudicants

“…[10][11][12][13] The low proportion of all referred claudicants included in most IC interventional trials makes it difficult to generalize results to the majority of IC patients.…”

“…9 Most available studies evaluating invasive treatment have used rather selective inclusion criteria, enrolling patients with vascular lesions (eg, in specific vessel segments, of a certain length and severity, and with suitable anatomy for endovascular treatment). [10][11][12][13] The low proportion of all referred claudicants included in most IC interventional trials makes it difficult to generalize results to the majority of IC patients. 14 In this context, we sought to perform a "real world" study to test the hypothesis that an invasive (surgical or endovascular) treatment strategy compared with continued medical therapy improves HRQoL in relatively unselected IC patients receiving best medical treatment and structured (nonsupervised) training advice.…”