The osseointegration and stability of dental implants with different surface treatments in animal models: a network meta-analysis

Hao, Chun-Ping; Cao, Nanjue; Zhu, Yuhe; Wang, Wei

doi:10.1038/s41598-021-93307-4

Cited by 34 publications

(19 citation statements)

References 48 publications

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“…For decades the canine model has been the preferred platform in implant dentistry due to its availability, handling, anatomic and biologic similarities. Several studies have observed comparable osseointegration rates for the canine and minipig intraoral implant models [ 88 ]. A meta-analysis comparing titanium and zirconia implants reported an overall BIC of 60.4% (95%CI: 52.8–67.9%) for titanium implants using a wide range of healing intervals [ 89 ].…”

Section: Discussionmentioning

confidence: 99%

The minipig intraoral dental implant model: A systematic review and meta-analysis

et al. 2022

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Objectives The objective of this report was to provide a review of the minipig intraoral dental implant model including a meta-analysis to estimate osseointegration and crestal bone remodeling. Methods A systematic review including PubMed and EMBASE databases through June 2021 was conducted. Two independent examiners screened titles/abstracts and selected full-text articles. Studies evaluating titanium dental implant osseointegration in native alveolar bone were included. A quality assessment of reporting was performed. Random-effects meta-analyses and meta-regressions were produced for bone-implant contact (BIC), first BIC, and crestal bone level. Results 125 out of 249 full-text articles were reviewed, 55 original studies were included. Quality of reporting was generally low, omissions included animal characteristics, examiner masking/calibration, and sample size calculation. The typical minipig model protocol included surgical extraction of the mandibular premolars and first molar, 12±4 wks post-extraction healing, placement of three narrow regular length dental implants per jaw quadrant, submerged implant healing and 8 wks of osseointegration. Approximately 90% of studies reported undecalcified incandescent light microscopy histometrics. Overall, mean BIC was 59.88% (95%CI: 57.43–62.33). BIC increased significantly over time (p<0.001): 40.93 (95%CI: 34.95–46.90) at 2 wks, 58.37% (95%CI: 54.38–62.36) at 4 wks, and 66.33% (95%CI: 63.45–69.21) beyond 4 wks. Variability among studies was mainly explained by differences in observation interval post-extraction and post-implant placement, and implant surface. Heterogeneity was high for all studies (I2 > 90%, p<0.001). Conclusions The minipig intraoral dental implant model appears to effectively demonstrate osseointegration and alveolar bone remodeling similar to that observed in humans and canine models.

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Section: Discussionmentioning

confidence: 99%

The minipig intraoral dental implant model: A systematic review and meta-analysis

et al. 2022

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“…Dental implants are being increasingly used due to high success rates [1,2]. However, a large number of patients do not have sufficient minimum bone conditions for implant placement, requiring previous bone reconstructive surgery.…”

Section: Major Findingsmentioning

confidence: 99%

“…In the scenario of implantology and osseointegration process, the maxillary sinus is the largest of the paranasal sinuses with fundamental functions for phonatory resonance, conditioning the air, to equalize the pressures in the nasal cavity that is covered by Schneider's membrane [1][2][3]. The importance of knowing the constitution of this epithelium is because these hair cells play a fundamental role in the physiology of the maxillary sinus [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Molecular, cellular and surgical processes of osseointegration for dental implants: a systematic review

Sousa¹,

Cardoso²,

Cicareli³

et al. 2022

MedNEXT

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Introduction: The maxillary sinus floor elevation procedure should be performed based on the cellular and molecular process of osseointegration. In this sense, when grafting procedures are necessary, the success and predictability of the results do not depend only on the biomaterial, but as well as the morphology of the bone defect. Combinations have been proposed to obtain better regenerative conditions through volume preservation (osteoconduction) and induction of cell migration differentiation (osteoinduction). The surface microstructure of Bio Oss® supports the growth of osteoblasts, which are responsible for bone formation. Objective: To carry out a concise systematic review of the molecular and surgical processes of osseointegration for dental implants. Methods: The present study was followed by a systematic review model (PRSMA). The search strategy was performed in the PubMed, Cochrane Library, Web of Science and Scopus, and Google Scholar databases. The Cochrane Instrument was used to assess the risk of bias from the included studies. Results and Conclusion: In line with the objective of this study, it was observed that the understanding of bone bioengineering, understanding the entire bioprocess of bone formation through the main cells (mesenchymal stem cells and osteoblasts) and molecules (BMPs, PRP, PRF, cytokines and growth factors), can promote the use of biomaterials and epithelial barriers that help in the treatment as an adjuvant to bone grafting-techniques, favoring greater predictability in alveolar and peri-implant reconstructions and with a good prognosis.

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“…Although dental implants overcome some disadvantages of dentures and effectively repair defects caused by tooth loss, two conditions still hinder the development of dental implant technology: 1) insufficient local bone mass in the implants ( Pardal-Peláez et al, 2021 ) and 2) insufficient soft tissue around the implants ( Noh et al, 2021 ). Dental implant tissue engineering mainly uses tissue engineering technology and changes the alveolar bone and soft tissue environment before the implant is implanted into the alveolar bone in the edentulous area to achieve good osseointegration ( Hao et al, 2021 ) and soft tissue augmentation.…”

Section: Dental Implant Tissue Engineeringmentioning

confidence: 99%

Tissue Engineering in Stomatology: A Review of Potential Approaches for Oral Disease Treatments

Cao

et al. 2021

Front. Bioeng. Biotechnol.

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Tissue engineering is an emerging discipline that combines engineering and life sciences. It can construct functional biological structures in vivo or in vitro to replace native tissues or organs and minimize serious shortages of donor organs during tissue and organ reconstruction or transplantation. Organ transplantation has achieved success by using the tissue-engineered heart, liver, kidney, and other artificial organs, and the emergence of tissue-engineered bone also provides a new approach for the healing of human bone defects. In recent years, tissue engineering technology has gradually become an important technical method for dentistry research, and its application in stomatology-related research has also obtained impressive achievements. The purpose of this review is to summarize the research advances of tissue engineering and its application in stomatology. These aspects include tooth, periodontal, dental implant, cleft palate, oral and maxillofacial skin or mucosa, and oral and maxillofacial bone tissue engineering. In addition, this article also summarizes the commonly used cells, scaffolds, and growth factors in stomatology and discusses the limitations of tissue engineering in stomatology from the perspective of cells, scaffolds, and clinical applications.

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The osseointegration and stability of dental implants with different surface treatments in animal models: a network meta-analysis

Cited by 34 publications

References 48 publications

The minipig intraoral dental implant model: A systematic review and meta-analysis

The minipig intraoral dental implant model: A systematic review and meta-analysis

Molecular, cellular and surgical processes of osseointegration for dental implants: a systematic review

Tissue Engineering in Stomatology: A Review of Potential Approaches for Oral Disease Treatments

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