The osteogenic effects of porous Tantalum and Titanium alloy scaffolds with different unit cell structure

Huang, Gan; Pan, Shuting; Qiu, Jiaxuan

doi:10.1016/j.colsurfb.2021.112229

Cited by 35 publications

(17 citation statements)

References 55 publications

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“…In vivo, new bone formation was higher for Ta scaffolds than Ti6Al4V ones, with increased bone ingrowth and osseointegration. Similar results were reported elsewhere [ 91 , 92 , 93 ].…”

Section: Bone Tissue Regeneration Induced By Tantalumsupporting

confidence: 93%

Tantalum as Trabecular Metal for Endosseous Implantable Applications

Carraro

Bagno

2023

Biomimetics

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During the last 20 years, tantalum has known ever wider applications for the production of endosseous implantable devices in the orthopedic and dental fields. Its excellent performances are due to its capacity to stimulate new bone formation, thus improving implant integration and stable fixation. Tantalum’s mechanical features can be mainly adjusted by controlling its porosity thanks to a number of versatile fabrication techniques, which allow obtaining an elastic modulus similar to that of bone tissue, thus limiting the stress-shielding effect. The present paper aims at reviewing the characteristics of tantalum as a solid and porous (trabecular) metal, with specific regard to biocompatibility and bioactivity. Principal fabrication methods and major applications are described. Moreover, the osteogenic features of porous tantalum are presented to testify its regenerative potential. It can be concluded that tantalum, especially as a porous metal, clearly possesses many advantageous characteristics for endosseous applications but it presently lacks the consolidated clinical experience of other metals such as titanium.

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“…In vivo, new bone formation was higher for Ta scaffolds than Ti6Al4V ones, with increased bone ingrowth and osseointegration. Similar results were reported elsewhere [ 91 , 92 , 93 ].…”

Section: Bone Tissue Regeneration Induced By Tantalumsupporting

confidence: 93%

Tantalum as Trabecular Metal for Endosseous Implantable Applications

Carraro

Bagno

2023

Biomimetics

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“…Cell adhesion is the first step in the reaction between cell and material, and the physicochemical properties and surface characteristics of the material can have an important impact. Tantalum's inherent high wettability and surface energy as well as its rough micro/nanosurface structure facilitate protein adsorption and cell adhesion (Huang et al, 2022). SEM showed that MSCs on the surface of each material were fully spread and protruding pseudopodia by 1 day of culture.…”

Section: Discussionmentioning

confidence: 99%

Influence of porosity on osteogenesis, bone growth and osteointegration in trabecular tantalum scaffolds fabricated by additive manufacturing

Jiao

Hong²,

Zhang³

et al. 2023

Front. Bioeng. Biotechnol.

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Porous tantalum implants are a class of materials commonly used in clinical practice to repair bone defects. However, the cumbersome and problematic preparation procedure have limited their widespread application. Additive manufacturing has revolutionized the design and process of orthopedic implants, but the pore architecture feature of porous tantalum scaffolds prepared from additive materials for optimal osseointegration are unclear, particularly the influence of porosity. We prepared trabecular bone-mimicking tantalum scaffolds with three different porosities (60%, 70% and 80%) using the laser powder bed fusing technique to examine and compare the effects of adhesion, proliferation and osteogenic differentiation capacity of rat mesenchymal stem cells on the scaffolds in vitro. The in vivo bone ingrowth and osseointegration effects of each scaffold were analyzed in a rat femoral bone defect model. Three porous tantalum scaffolds were successfully prepared and characterized. In vitro studies showed that scaffolds with 70% and 80% porosity had a better ability to osteogenic proliferation and differentiation than scaffolds with 60% porosity. In vivo studies further confirmed that tantalum scaffolds with the 70% and 80% porosity had a better ability for bone ingrowh than the scaffold with 60% porosity. As for osseointegration, more bone was bound to the material in the scaffold with 70% porosity, suggesting that the 3D printed trabecular tantalum scaffold with 70% porosity could be the optimal choice for subsequent implant design, which we will further confirm in a large animal preclinical model for better clinical use.

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“…Based on these benefits, a diamond lattice is widely incorporated in porous scaffolds [ 77 ]. On the other hand, rhombic dodecahedron lattice has a higher yield stress and is stable under multi-directional compression forces, thereby making it an ideal choice for manufacturing load-bearing implants [ 28 , 78 ]. However, care should be taken that the dodecahedron shape is designed with only obtuse angles, as acutely angled pores are easily damaged during the melting stage of printing.…”

Section: Discussionmentioning

confidence: 99%

3D-printed porous Ti6Al4V scaffolds for long bone repair in animal models: a systematic review

Sun

Shujaat

et al. 2022

J Orthop Surg Res

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Background Titanium and its alloys have been widely employed for bone tissue repair and implant manufacturing. The rapid development of three-dimensional (3D) printing technology has allowed fabrication of porous titanium scaffolds with controllable microstructures, which is considered to be an effective method for promoting rapid bone formation and decreasing bone absorption. The purpose of this systematic review was to evaluate the osteogenic potential of 3D-printed porous Ti6Al4V (Ti64) scaffold for repairing long bone defects in animal models and to investigate the influential factors that might affect its osteogenic capacity. Methods Electronic literature search was conducted in the following databases: PubMed, Web of Science, and Embase up to September 2021. The SYRCLE's tool and the modified CAMARADES list were used to assess the risk of bias and methodological quality, respectively. Due to heterogeneity of the selected studies in relation to protocol and outcomes evaluated, a meta-analysis could not be performed. Results The initial search revealed 5858 studies. Only 46 animal studies were found to be eligible based on the inclusion criteria. Rabbit was the most commonly utilized animal model. A pore size of around 500–600 µm and porosity of 60–70% were found to be the most ideal parameters for designing the Ti64 scaffold, where both dodecahedron and diamond pores optimally promoted osteogenesis. Histological analysis of the scaffold in a rabbit model revealed that the maximum bone area fraction reached 59.3 ± 8.1% at weeks 8–10. Based on micro-CT assessment, the maximum bone volume fraction was found to be 34.0 ± 6.0% at weeks 12. Conclusions Ti64 scaffold might act as a promising medium for providing sufficient mechanical support and a stable environment for new bone formation in long bone defects. Trail registration The study protocol was registered in the PROSPERO database under the number CRD42020194100.

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The osteogenic effects of porous Tantalum and Titanium alloy scaffolds with different unit cell structure

Cited by 35 publications

References 55 publications

Tantalum as Trabecular Metal for Endosseous Implantable Applications

Tantalum as Trabecular Metal for Endosseous Implantable Applications

Influence of porosity on osteogenesis, bone growth and osteointegration in trabecular tantalum scaffolds fabricated by additive manufacturing

3D-printed porous Ti6Al4V scaffolds for long bone repair in animal models: a systematic review

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