The osteogenic potential of seaweed: A systematic review and meta-analysis

Saleng, Suriani; Hendra, Faqi Nurdiansyah; Ruslin, Muhammad; Forouzanfar, Tymour; Helder, Marco N.

doi:10.1016/j.algal.2024.103445

Cited by 3 publications

(1 citation statement)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result, we initially discovered that, among edible algae, the water-extracted components of Sargassum horneri (Japanese name, Akamoku) have a strong effect on increasing bone calcium levels in rat femoral tissue in vitro [7]. After that, the components of several seaweeds have been reported to express osteogenic effects [8][9][10][11][12][13][14]. S. horneri is found along the coasts of Japan and China, growing from winter to spring on rocky areas of the ocean floor where the waves are relatively calm.…”

Section: Introductionmentioning

confidence: 99%

The Marine Alga Sargassum horneri Is a Functional Food with High Bioactivity

Yamaguchi

2024

Nutraceuticals

View full text Add to dashboard Cite

Functional food factors can play a preventive and therapeutic role in several human diseases. The marine alga Sargassum horneri (S. horneri) has restorative effects in several types of metabolic disorders, including osteoporosis, diabetes, inflammatory conditions, and cancer cell growth. Osteoporosis is widely recognized as a major public health problem. Bone loss associated with ageing and diabetic states was prevented through the intake of bioactive compounds from S. horneri water extract in vivo by stimulating osteoblastic bone formation and inhibiting osteoclastic bone resorption in vitro. The intake of S. horneri water extract was found to have preventive effects on diabetic findings with an increase in serum glucose and lipid components. Furthermore, the S. horneri component has been shown to suppress adipogenesis from rat bone marrow cells and inflammatory conditions in vitro. Notably, the growth of bone metastatic human breast cancer MDA-MB-231 cells, which induce bone loss with osteolytic effects, was suppressed through culturing with the S. horneri water extract component in vitro. The S. horneri component, which has a molecular weight of less than 1000, was found to suppress the activation of NF-κB signaling by tumor necrosis factor-α, a cytokine associated with inflammation, in osteoblastic cells and macrophage RAW264.7 cells in vitro, suggesting a molecular mechanism. The bioactive component of S. horneri may play a multifunctional role in the prevention and treatment of metabolic disorders. This review outlines the advanced knowledge of the biological activity of the aqueous extract components of S. horneri and discusses the development of health supplements using this material.

show abstract