The Osteogenic Role of Biomaterials Combined with Human-Derived Dental Stem Cells in Bone Tissue Regeneration

Research progress in cell therapy for oral diseases: focus on cell sources and strategies to optimize cell function

“…MEG3 lncRNA is localized in the cytoplasm and interacts with enhancer of zeste homolog 2 (EZH2). Downregulation of MEG3 or EZH2 reduced H3K27me3 levels at the Wnt promoter, activating the Wnt/beta-catenin signaling pathway at the epigenetic level and subsequently promoting osteoblast differentiation of dental follicle stem cells (DFSCs) ( Abuarqoub et al, 2023 ).…”

Exploring calcium-free alternatives in endochondral bone repair tested on In vivo trials - A review

“…However, materials other than calcium-based composites have gradually become the focus of attention in bone tissue engineering constructs. Research on non-calcium-based composites has led to the development of innovative scaffold materials and fabrication techniques that may improve outcomes in BTE [ 16 ]. The use of non-calcium-based composites reduces the risk of unwanted calcification or mineralization in surrounding tissues, a common problem with calcium-based materials.…”

“…The use of non-calcium-based composites reduces the risk of unwanted calcification or mineralization in surrounding tissues, a common problem with calcium-based materials. In addition, non-calcium composites may offer better biocompatibility for certain applications, which could reduce immune responses or adverse reactions in the body [ 16 ]. However, non-calcium-based composites also have limitations.…”