The osteoporosis of rheumatoid arthritis

Duncan, Howard; Frost, Harold M.; Villanueva, A. R.; Sigler, John W.

doi:10.1002/art.1780080504

Cited by 60 publications

(12 citation statements)

References 27 publications

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“…There was no difference between the 2 groups in total osteoid surface. These results differ from those of Duncan et al, who found inactive osteoid seams to be increased in ribs of' patients with RA (19). The systemic trabecular osteopenia found in RA may differ from localized osteopenia in the periarticular trabecular bone.…”

Section: Discussioncontrasting

confidence: 87%

Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis

Shimizu

Shiozawa

et al. 1985

Arthritis & Rheumatism

140

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The pathogenesis of periarticular osteopenia in rheumatoid arthritis (RA) was investigated by histomorphometry on juxtaarticular bone removed during joint surgery. Twenty areas from 12 RA patients were compared with 14 areas from 6 osteoarthritis (OA) patients. There was no difference between the 2 groups in the percent of total bone volume. However, increased bone formation was suggested by an increase in the percent of active osteoid surface in RA compared with that in OA. Bone resorption was also increased in RA, as evidenced by increases versus OA in percent total resorptive surface, percent active resorptive surface, and number of osteoclasts. These results demonstrate increased turnover of bone in RA, especially in the resorptive phase of the periarticular trabecular bone. It is proposed that soluble factor(s) synthesized in the contiguous rheumatoid synovium may be transferred to the periarticular bone space, stimulating osteoclasts to resorb bone.

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Section: Discussioncontrasting

confidence: 87%

Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis

Shimizu

Shiozawa

et al. 1985

Arthritis & Rheumatism

140

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“…A similar explanation is sometimes offered to explain the bone loss observed in human rheumatoid arthritis (17).…”

Section: Discussionmentioning

confidence: 89%

Juxtaarticular bone loss in experimental inflammatory arthritis

Bogoch

Gschwend

Bogoch

et al. 1988

Journal Orthopaedic Research

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The osteopenia associated with experimental inflammatory arthritis was studied by a histomorphometric method that exphasized net changes in bone composition. Juxtaarticular trabecular bone volume and turnover were studied in the carrageenan injection model of inflammatory arthritis of the mature rabbit knee. Trabecular bone volume was studied by histomorphometry of the femoral condyles and confirmed by photodensitometry on standard macroradiographs. Osteogenesis was studied by imaging of calcein fluorochrome-labeled newly formed bone in undecalcified histological sections. A significant net loss of cancellous bone (approximately 20%) occurred over 49 days in both the medial and the lateral femoral condyle in the arthritis group compared with normal controls. Total osteogenesis was increased fourfold and it was calculated that an even greater increase in total bone resorption was responsible for the negative bone balance. There is evidence that the periarticular bone loss of human rheumatoid arthritis is also associated with increased bone turnover. Quantitative studies of the kinetics of bone remodeling in inflammatory arthritis will provide the basis for therapeutic attempts to prevent or reverse arthritis-induced bone loss. Fracture risk in inflammatory arthritis may be increased not only by osteopenia, but additionally by the presence of a large proportion of newly formed (and presumably less mineralized) bone.

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“…Eventually the osteoporosis becomes generalized, reflecting a systemic inhibition of osteogenesis. 4 The earliest joint changes in the foot occur at the first, fourth, and fifth metatarsophalangeal joints. 7 The talonavicular joint is often the first tarsal articulation to be involved, although all of the tarsal joints eventually undergo uniform destruction (Fig.…”

Section: Rheumatoid Arthritis Of Adult Onsetmentioning

confidence: 99%

Radiologic Evaluation of the Arthritic Foot

Gold¹,

Bassett²

1982

Foot & Ankle

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The presence or absence of erosions, periosteal new bone, and osteoporosis, as well as differences in their character and distribution, serve as radiologic clues to the differential diagnosis of the various arthritides that affect the foot. In this article we have emphasized these differences as -they pertain to the following conditions: rheumatoid arthritis of adult onset, psorlatlc arthritis, Reiter disease, ankylosing spondylitis, rheumatoid arthritis of childhood onset, osteoarthritis, gout, systemic lupus erythematosus, progressive systemic slcerosis, calcium pyrophosphate dihydrate deposition disease, and neuropathic joint disease.

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The osteoporosis of rheumatoid arthritis

Cited by 60 publications

References 27 publications

Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis

Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis

Juxtaarticular bone loss in experimental inflammatory arthritis

Radiologic Evaluation of the Arthritic Foot

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