1962
DOI: 10.1016/s0022-3476(62)80041-9
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The ototoxic effects of kanamycin sulfate in infants and children

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Cited by 27 publications
(4 citation statements)
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“…If the concentration seemed to rise, the dose could be lowered and an antibacterial level still sufficient was maintained. These results differ even more from those of Sanders et al (1967) and Yow et al (1962 , but the doses used in our material are smaller and the patients were monitored more ade quately.…”
Section: Discussioncontrasting
confidence: 74%
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“…If the concentration seemed to rise, the dose could be lowered and an antibacterial level still sufficient was maintained. These results differ even more from those of Sanders et al (1967) and Yow et al (1962 , but the doses used in our material are smaller and the patients were monitored more ade quately.…”
Section: Discussioncontrasting
confidence: 74%
“…The serum kanamycin levels of these patients are not reported. The serum level varies greatly, depending on the renal function, and thus may rise to toxic limits ( Yow et al, 1962). The control age of 4 -5 years is rather low, if we want to achieve reliable results.…”
Section: Introductionmentioning
confidence: 99%
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“…The use of aminoglycosides has been studied previously, first by Yow et al 14 in 1962, who showed that the risk of hearing loss was increased with cumulative kanamycin doses above 500 mg/kg with normal renal function, seeming to confirm adult and animal evidence for ototoxicity and interaction between aminoglycoside and other factors, such as acoustic trauma. Suggestions of aminoglycoside toxicity12 13 have not been confirmed, and a prospective study comparing infants treated with kanamycin and gentamicin with unexposed controls failed to show any association despite a large trial group 15.…”
Section: Discussionmentioning
confidence: 95%