The outbreak of the new coronavirus infection in pediatric TB department

Abstract

The objective: to analyze the course of the new coronavirus infection (COVID-19) in children with active respiratory tuberculosis. Subjects and methods. The article describes results of retrospective analysis of the course of the new coronavirus infection in 25 children (3-12 years old) with active respiratory tuberculosis during the outbreak of COVID-19 in an in-patient TB unit.Results. 24 (96%) persons got infected after the close exposure to the coronavirus infection, and 1 (4%) child didn't get infected. The diagnosis was verified by polymerase chain reaction (detection of RNK of SARS-CoV-2) in 33.3%, by enzyme immunoassay (detection of IgG antibodies to SARS-CoV-2 in 1 month after quarantine removal) in 100%. 58.3% of children with respiratory tuberculosis (14 people) infected with coronavirus infection had minimal respiratory symptoms, that did not differ from signs of other respiratory viral infections; clinical manifestations of the disease were completely absent in 41.7% (10) patients. Coronavirus pneumonia was diagnosed in 4 (16.7%) children who suffered from COVID-19, they had no clinical signs of lower respiratory tract disorders and no body temperature increase; 3 patients had no signs of respiratory viral infection; in all cases, the lung damage detected by computed tomography didn't exceed 10%. In 2 months after the removal of quarantine, no IgG antibodies to SARS-CoV-2 were detected in 2 out of 10 examined children (20.0%), thus there was a chance for re-infection. No mutual aggravating effect of coronavirus infection and tuberculosis was revealed in their combination over the entire observation period (4 months).

Global prevalence, treatment and outcome of tuberculosis and COVID-19 coinfection: a systematic review and meta-analysis (from November 2019 to March 2021)

“… 57 Thus, we removed the overlapped cohort. Except for Gubkina et al ’s study whose targeted population was children and no one deceased, 59 the overall and in-hospital fatality rates fell within 5.3%~23.6% and 5.0%~27.3%. Table 2 presents the results of the included seven studies.…”

“…We identified seven retrospective cohort studies that revealed the fatality rate of TB–COVID coinfection (online supplemental table 6 for detailed information). These studies came from India,55 the Philippines,56 Italy,57 South Africa,54 Argentina58 and Russia,59 and one was based on data from multiple countries 53. Motta et al ’s study provided two cohorts,53 one of which was the same as Stochino et al ’s study 57.…”

The association of SARS-CoV-2 infection and tuberculosis disease with unfavorable treatment outcomes: A systematic review

“…Three studies (38%) recruited participants in 2021 [ 14 , 17 , 19 ]. One study focused on children [ 16 ], while the remainder involved adults [ 13 – 15 , 17 – 19 , 23 ]. Participants were predominantly male, driven mostly by one study consisting of 5409 participants of whom 66% were male ( Table 1 ) [ 19 ].…”

“…Point estimates for odds ratios in the included studies ranged from 0.36 to 1.29. In two studies [ 13 , 16 ], no unfavorable outcomes occurred in either group. Few subgroup analyses were possible with the available data and results remained heterogeneous (see S3 Text ).…”

Tuberculosis and COVID-19 in Children and Adolescents. Two Waves of the Pandemic: Experiences and Conclusions

“…Также нельзя исключить факт, что туберкулез может способствовать тяжелому течению коронавирусной инфекции. В настоящее время есть единичные работы о взаимном влиянии туберкулеза и COVID-19 на их течение и исходы у детей и подростков [1,5,6].…”