The outcome of ankylosing spondylitis: a study of 100 patients.

Gran, Jan Tore; Skomsvoll, Johan Fredrik

doi:10.1093/rheumatology/36.7.766

Cited by 246 publications

(146 citation statements)

References 25 publications

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“…Serial blood samples were collected in anticoagulant tubes containing EDTA at specified times during the study (2,4,12,24,36,48,60,72,84,96,120,144,168,216,264,312,384, and 480 h after the first dose). Plasma samples were isolated from fresh blood by centrifugation and stored at -20 °C.…”

Section: Methodsmentioning

confidence: 99%

“…Many patients have localized new bone formation, ligamentous ossification, and progressive deformities that, without treatment, often lead to disability. A recent Norwegian study showed that the cessation of physical work in patients with AS occurred at an average disease duration of 15.6 years [2] . Currently, there is no cure for AS, but available therapies, such as individualized physical therapy and nonsteroidal anti-inflammatory drugs (NSAIDs), target symptoms and pain [3] .…”

Section: Introductionmentioning

confidence: 99%

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Population pharmacokinetics of rhTNFR-Fc in healthy Chinese volunteers and in Chinese patients with Ankylosing spondylitis

Fang

Wang

et al. 2010

Acta Pharmacol Sin

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Aim:To investigate the population pharmacokinetics of recombinant human tumor necrosis factor receptor-Fc fusion protein (rhTNFRFc) administered via subcutaneous (SC) injection in healthy Chinese volunteers and in Chinese patients with ankylosing spondylitis (AS). Methods: Thirty-two healthy volunteers were randomly assigned to receive a single SC injection of 12.5, 25, 37.5, or 50 mg of rhTNFRFc. Twenty male patients with moderate AS were randomly assigned to receive seven consecutive SC injections of rhTNFR-Fc at either 25 mg twice a week (BIW) or 50 mg once a week (QW). Population pharmacokinetic (PK) analysis was applied to obtain PK parameters of rhTNFR-Fc by the NONMEM method. Results: The data were best described by a one-compartment model with lag time. We found that gender had a significant effect on the apparent clearance (CL/F), with the male CL/F ratio being only 0.665 times the female ratio; the absorption coefficient (F) of multiple dosages of rhTNFR-Fc was only 0.674 times that of a single dosage. The outcome parameters were CL/F (female: 0.168 L/h, male: 0.110 L/h), the apparent volume of distribution (Vd/F: 15.5 L), the absorption rate constant (Ka) (single dosage: 0.0605 h -1 , multiple dosage: 0.0408 h -1 ), and the lag time (T lag : 1.03 h). The inter-individual variability in the CL/F, Vd/F, Ka, and T lag were 33.3%, 42.7%, 55.6%, and 81.8%, respectively. Conclusion: Chinese females have a higher CL/F than Chinese males, and multiple dosings can significantly decrease the absorption of rhTNFR-Fc (SC). The population PK parameters of rhTNFR-Fc in healthy Chinese volunteers and patients with AS were similar to those reported for subjects in published American studies.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Population pharmacokinetics of rhTNFR-Fc in healthy Chinese volunteers and in Chinese patients with Ankylosing spondylitis

Fang

Wang

et al. 2010

Acta Pharmacol Sin

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“…The late changes of ankylosis and osteoarthritis can lead to loss of function and total joint arthroplasty in 8-15% of patients. 46,93 Despite the increased ankylosis of joints, patients with AS commonly have decreased bone mineral density with consequent presentations of nontraumatic fractures in young, male patients. Osteoporosis of the femoral neck occurs in one third of patients, with osteopenia afflicting a further 41%.…”

Section: Neurosurg Focus / Volume 24 / January 2008mentioning

confidence: 99%

The pathogenesis of ankylosing spondylitis

Shamji

Bafaquh²,

Tsai³

2008

FOC

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✓ Ankylosing spondylitis (AS) is a chronic inflammatory disease that can cause significant functional complications by affecting the sacroiliac joints and axial skeleton. Despite a longstanding knowledge about the familial associations of this disease, particularly among patients positive for human leukocyte antigen (HLA)–B27, the fundamental pathogenetic mechanism by which this disease arises in genetically susceptible individuals remains ill defined. Furthermore, the molecular predilection for characteristic articular site involvement remains under ongoing investigation. Current theories about the HLA-B27 association range from the presentation of novel arthritogenic peptides, to abnormal autoimmune stimulation, to anomalous microbial tolerance. The immune effectors of this damage include CD4+, CD8+, and natural killer cells, with marked heterogeneity at different sites. Biomechanical stresses may trigger this disease by exposing the body to previously immune-sequestered autoantigens or by providing a route for bacterial seeding. Environmental triggers such as infection have not been definitively established but may represent a primary pathogenic step in a molecular-mimicry process. In this article, the authors review the current literature on the origin and pathophysiology of AS, focusing on genetic and molecular associations, consequent pathomechanisms, and associated triggers. An improved understanding of the sequence of molecular events that predispose and initiate the onset of this disease will allow for more specific and targeted therapy and better avoidance of the significant side effects of systemic immunomodulation.

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“…Волну-хина и соавт. [3] и ряда других авторов [13], хотя в литера-туре разброс данных по нетрудоспособности весьма велик. Так, S.M.…”

Section: результатыunclassified

Correlation Between Clinical Characteristics of Ankylosing Spondylitis and Work Capacity and Productivity

Подряднова¹,

Rm²,

Урумова³

et al. 2014

rsp

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Анкилозирующим спондилитом (АС) страдает 0,1-1,6% населения [1], причем пре-имущественно трудоспособного возраста. Развитие АС сопровождается нарастанием бо-ли, скованности и ограничения функции по-звоночника, что приводит к существенному снижению качества жизни (КЖ) [2], ранней инвалидизации и сокращению продолжи-тельности жизни пациентов. Возникают огра-ничения в профессиональной и повседневной О р и г и н а л ь н ы е и с с л е д о в а н и я The strongest correlation detected was that between WPAI aspects (R>0.5) and the intensity of pain assessed by visual analogue scale. BASFI index showed moderate correlation -with GRP (R=0.30) and close -with presenteeism and reduction in ADL (R=0.56 and R=0.71 respectively) and did not correlatewith absenteeism. Conclusion. AS activity was the main factor influencing work productivity. Presenteeism correlates with clinical characteristics of AS considerably stronger than absenteeism. All WPAI aspects correlated with the disease activity and degree of functional impairment.

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The outcome of ankylosing spondylitis: a study of 100 patients.

Cited by 246 publications

References 25 publications

Population pharmacokinetics of rhTNFR-Fc in healthy Chinese volunteers and in Chinese patients with Ankylosing spondylitis

Population pharmacokinetics of rhTNFR-Fc in healthy Chinese volunteers and in Chinese patients with Ankylosing spondylitis

The pathogenesis of ankylosing spondylitis

Correlation Between Clinical Characteristics of Ankylosing Spondylitis and Work Capacity and Productivity

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