The Outcome of Assisted Reproductive Techniques among Couples with Male Factors at Prince Khalid Bin Sultan Fertility Centre, Kingdom of Saudi Arabia

Mukhtar, Hytham Bahaeldin; Shaman, Amani; Mirghani, Hyder Osman; Almasalmah, Ayman Adnan

doi:10.3889/oamjms.2017.102

Cited by 8 publications

(7 citation statements)

References 25 publications

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“…Insight into the literature on male infertility and its causes in Saudi Arabia, very few studies were reported from this region. Mukhtar and his group (2017) found that about half million couples require assisted conception ( Mukhtar et al, 2017 ). Male factor infertility (72%) was accountable for increased rate of infertility among infertile couples ( Alasmari et al, 2018 , Alosaimi et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of trace elements on the seminal oxidative status and correlation to sperm motility in infertile Saudi males

Aljaser

Tabassum

Fatima

et al. 2021

Saudi Journal of Biological Sciences

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The impact of trace elements, especially zinc, selenium, copper, and magnesium, on male fertility has gained great interest and significance. Increased oxidative stress and altered trace element levels are probable etiological factors underlying male reproductive dysfunction and infertility. The present study focused on the evaluation of seminal oxidative markers, such as reactive oxygen species (ROS), malondialdehyde (MDA), and total antioxidant capacity (TAC), and trace element levels in the normozoospermic fertile control group (n = 40) and asthenozoospermic infertile group (n = 30). Semen from infertile men exhibited significantly higher ROS and MDA levels accompanied with significant decline in TAC and trace element (zinc and magnesium) levels. Furthermore, a significant correlation was observed between trace elements and oxidative markers with sperm motility. The current study revealed increased lipid peroxidation and oxidant-reductant imbalance that leads to deterioration of semen quality and male infertility. Thus, oxidative stress and trace elements can be considered important biomarkers of male infertility. Measurement of seminal oxidative stress with conventional seminological parameters must be integrated in fertility assessment from early stages to ensure healthy semen characteristics and fertility in men.

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Section: Introductionmentioning

confidence: 99%

Effect of trace elements on the seminal oxidative status and correlation to sperm motility in infertile Saudi males

Aljaser

Tabassum

Fatima

et al. 2021

Saudi Journal of Biological Sciences

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“…Especially, studies on the incidence and the causes of male infertility and reproductive disorders are hardly available. Limited information available reveals that infertility is a serious problem with an incidence of 19% (Al‐Turki, ) and about half million couples are needing help with ART (Mukhtar, Shaman, Mirghani, & Almasalmah, ). Alarmingly, in a recent study on 2,317 infertile couples, 72% of problem was attributed to male factor infertility (Alasmari et al, ).…”

Section: Introductionmentioning

confidence: 99%

Genetic investigations on causes of male infertility in Western Saudi Arabia

et al. 2019

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In recent years, genetic studies have yielded great progress in elucidating causes of male infertility. This investigation aims to identify frequent genetic abnormalities, that is, sex chromosome aneuploidies and Y‐chromosome microdeletions among infertile men in Western Saudi Arabia. From a population of infertile patients, 88 male patients with either azoospermia or severe oligozoospermia (sperm concentration <5 million/ml) were selected. In addition to a thorough clinical workup, karyotypes and Y‐chromosomal microdeletions were investigated. Among those 88 infertile patients, we detected six patients with Klinefelter syndrome, two with 47 XYY syndrome and two with Y‐chromosome microdeletions AZFb,c. While the prevalence of sex chromosome aneuploidies was in the range of globally investigated populations, the microdeletions appeared to be less frequent in Western Saudi Arabia compared to other regions of the world. All genetically abnormal cases showed sperm concentration <1 million/ml, and hence, this appears to be the threshold for warranting genetic investigations in Western Saudi Arabia. Since Klinefelter and 47 XYY syndromes were only discovered late in life, upon an infertility investigation, sex chromosome aneuploidies due to their many‐fold comorbidities require earlier medical attention. A neonatal screening programme is suggested for detection of these aneuploidies in Saudi Arabia for the general health benefit of these patients.

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“…Cases with male-associated infertility factors were grouped into two categories: spermatic diseases (19%) and testicular diseases (14%). Women with male-associated infertility factors had the highest pregnancy rate using in vitro fertilization [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Live Birth Rate Comparison Between Single vs. Double Ovary Women With Assisted Reproduction: A Single Tertiary Center Study

Aljahdali¹,

Alkhaldi²,

Almujarri³

et al. 2021

Cureus

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Introduction One of the major hardships faced by married couples is the inability to conceive a child. This issue is becoming more prevalent given the increasing rate of infertility worldwide. Assisted reproductive technology (ART) has brought hope to infertile couples. We aim to estimate the live birth rate (LBR) and pregnancy rate in women with one ovary compared with those with two ovaries. Methods A retrospective cohort study of women who underwent ART at King Abdulaziz Medical City (Jan 2000 - Dec 2018) was conducted. Five cycles of patient data were collected. The LBR (both conditional and cumulative) was compared between women with one and two ovaries. Results The final analysis included 403 women. Of these, 9% (n = 37) had one ovary. The majority (59%, n = 233) had primary infertility. A male-associated factor accounted for 52% (n = 208) of the infertility cases. The total number of live births was 164; and the overall LBR from five cycles was estimated as 9%, 16%, 18%, 18%, and 15%, respectively. In the double ovary group, the highest rate was in the fourth cycle [19% (12-26)], while in the single ovary group peaked in the third cycle [27% (9-46)]. Pregnancy was at its highest in the first cycle, accounting for 88 pregnancies. Conclusion The outcomes of ART varied between study groups. LBR was lower in single ovary women. The average of five cycles in the single and double ovary groups was 13% and 15%, respectively. Nevertheless, there was no significant difference in LBR between single or double ovary women.

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The Outcome of Assisted Reproductive Techniques among Couples with Male Factors at Prince Khalid Bin Sultan Fertility Centre, Kingdom of Saudi Arabia

Cited by 8 publications

References 25 publications

Effect of trace elements on the seminal oxidative status and correlation to sperm motility in infertile Saudi males

Effect of trace elements on the seminal oxidative status and correlation to sperm motility in infertile Saudi males

Genetic investigations on causes of male infertility in Western Saudi Arabia

Live Birth Rate Comparison Between Single vs. Double Ovary Women With Assisted Reproduction: A Single Tertiary Center Study

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