The outcome of intervertebral surgery in the treatment of lumbar tuberculosis in children

Liang, Qiang; Pu, Yu; Wang, Qian; Shi, Jiandang; Sun, Guangwei; Liu, Liehua; Jin, Weidong; Wang, Zili

doi:10.1097/md.0000000000014815

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…The discovery of decreased gene expression related to T cell cytotoxic reaction provides an understanding of the decrease of serum granulysin concentration in children with acute tuberculosis [15]. These are contrary to the reported gene level studies of adult tuberculosis [16]. The RNA expression characteristics of adult TB have been reported previously, in which increased expression of IFN -γ -induced gene and neutrophil gene is observed [17].…”

Section: Discussionmentioning

confidence: 84%

Correlation between childhood tuberculosis and abundance of T cell gene transcription and impaired T cell function

Zhang¹,

Jia²,

Wang³

et al. 2022

Trop. J. Pharm Res

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Purpose: To investigate the relationship amongst childhood tuberculosis, abundance of T cell gene transcription and impairment of T cell function. Methods: A total of 329 pediatric patients treated for tuberculosis in Central Hospital of Zibo, Zibo, China from 2017 to 2019 were enrolled in the study. Among them, 167 cases of tuberculosis-hospitalized children were assigned to the TB group. Additionally, 162 well- and adequately-treated patients with a previous history of tuberculosis were selected as the control group. The abundance of continuous gene transcripts in the peripheral blood of the children was analyzed. The RNA profiles were analyzed via microarray, while interferon (IFN) level was measured by enzyme linked immunosorbent assay (ELISA). The T cell proliferation was determined by thymidine assay. Results: Within 6 months of the commencement of treatment, the differentially expressed transcripts returned the expression in children in the control group. The abundance of Talipes equinovarus, atrial septal defect, robin sequence, and the persistence of the left superior vena cava (TARP) gene transcription in the TB group was lower than in the control group on days 30, 120 and 180 (p < 0.05), while IL1R2 gene transcription abundance in the TB group was higher than in the control group on days 30, 120 ,180 (p < 0.05). The proliferation of T cells and IFNγ in tuberculosis children (TB group) were lower than in healthy controls (p < 0.05). In this study, a total of 129 genes were found to have significant differences in expression, and hence it is speculated that changes in RNA abundance altered the immune pathway. Conclusion: The reduced abundance of T cell gene transcription and renovated T cell function in children with tuberculosis are related to acquired immunodeficiency. The results of this study provide a theoretical basis for the clinical diagnosis and treatment of tuberculosis in children.

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Section: Discussionmentioning

confidence: 84%

Correlation between childhood tuberculosis and abundance of T cell gene transcription and impaired T cell function

Zhang¹,

Jia²,

Wang³

et al. 2022

Trop. J. Pharm Res

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“…Such types of asymmetrical growth may lead to eventual spinal imbalances. Furthermore, subperiosteal dissection of joints and lamina of normal motion units is avoided through single-segment fixation, which might facilitate reductions in probabilities of spontaneous fusion of adjacent segments and thus limit corresponding interference with spinal growth 20 . Moreover, single-segment fixation mostly has the benefit of furthering patient retention of levels of lumbar mobility, thereby reducing impacts upon daily life.…”

Section: Discussionmentioning

confidence: 99%

Clinical effectiveness of posterior-only approach using polyetheretherketone cage combined with single-segment instrumentation for lumbar tuberculosis in children

Zhang

Chen

Wang

et al. 2021

Sci Rep

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We sought to investigate the outcomes of posterior-only approach using polyetheretherketone (PEEK) cage combined with single-segment instrumentation (modified-approach) for mono-segment lumbar tuberculosis in children. Between February 2008 and August 2017 in our hospital, 18 children with single-segment lumbar tuberculosis enrolled in this study were treated by modified-approach. Medical records and radiographs were retrospectively analyzed. Mean follow-up time was 54.6 ± 12.1 months. No severe complications were noted to have occurred. Measures indicated there was satisfactory bone fusion for all patients. Mean Cobb angles were significantly decreased from preoperative angle (19.8° ± 13.1°) to those both postoperatively (− 4.9° ± 7.6°) and at final follow-up (− 3.5° ± 7.3°) (both P < 0.05), with a mean angle loss of 1.7° ± 0.9°. The erythrocyte sedimentation rate (ESR) returned to normal levels for all patients within 3 months postoperatively. All patients had significant postoperative improvement in neurological performance. The modified-approach was an effective and feasible treatment option for mono-segment children with lumbar tuberculosis. Such procedures can likely help patients by increasing retainment of lumbar mobility and reducing invasiveness.

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“…Such types of asymmetrical growth may lead to eventual spinal imbalances. Furthermore, subperiosteal dissection of joints and lamina of normal motion units is avoided through single-segment xation, which might facilitate reductions in probabilities of spontaneous fusion of adjacent segments and thus limit corresponding interference with spinal growth [20]. Moreover, single-segment xation mostly has the bene t of furthering patient retention of levels of lumbar mobility, thereby reducing impacts upon daily life.…”

Section: Discussionmentioning

confidence: 99%

Clinical Effectiveness of Treatment of Children Afflicted by Lumbar Tuberculosis With Posterior-only Approach Using Poly-ether-ether-ketone Cage Combined With Single-segment Instrumentation

Zhang¹,

Chen²,

Wang³

et al. 2021

Preprint

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Background: We sought to investigate the clinical outcomes of posterior-only approach using poly-ether-ether-ketone (PEEK) cage combined with single-segment instrumentation in the treatment of lumbar tuberculosis in children.Methods: Between February 2008 and August 2017 in our hospital, 18 children with single-segment lumbar tuberculosis were enrolled in this study. Children were treated by a posterior-only approach using PEEK cage combined with single-segment instrumentation. Medical records and radiographs were retrospectively analyzed. Visual analogue scores (VAS) were used to evaluate measures of quality of daily life. Criteria defined from the American Spinal Injury Association (ASIA) were used to evaluate measures of neurological function.Results: Mean follow-up time was 54.6 ± 12.1 months (39–84 months). No severe complications were noted to have occurred. Measures indicated there was satisfactory bone fusion for observations for all patients. Mean Cobb angles were significantly decreased from the mean preoperative angle (19.8° ± 13.1°) to those both postoperatively (-4.9° ± 7.6°) and at final follow-up (-3.5° ± 7.3°) (both P < 0.05), with a mean angle loss of 1.7° ± 0.9°. Th erythrocyte sedimentation rate (ESR) returned to normal levels for all patients within 3 months postoperatively. All patients had significant postoperative improvement in respect to neurological performance and VAS scores.Conclusions: The posterior-only approach using PEEK cage combined with single-segment instrumentation was found to be an effective and feasible treatment option for children with lumbar tuberculosis. Such procedures can likely be used to help patients by facilitating reconstruction of spinal stability, and increasing retainment of lumbar mobility in conjunction with reduced invasiveness compared to counterpart treatments.

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The outcome of intervertebral surgery in the treatment of lumbar tuberculosis in children

Cited by 6 publications

References 19 publications

Correlation between childhood tuberculosis and abundance of T cell gene transcription and impaired T cell function

Correlation between childhood tuberculosis and abundance of T cell gene transcription and impaired T cell function

Clinical effectiveness of posterior-only approach using polyetheretherketone cage combined with single-segment instrumentation for lumbar tuberculosis in children

Clinical Effectiveness of Treatment of Children Afflicted by Lumbar Tuberculosis With Posterior-only Approach Using Poly-ether-ether-ketone Cage Combined With Single-segment Instrumentation

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