The outcome of patients sustaining a proximal femur fracture who suffer from alcohol dependency

Unstable intertrochanteric femur fractures in geriatric patients treated with the DLT trochanteric nail

“…The overall time from the day of admission to surgery averaged 2.9 days (2-6). The mean postoperative followup time was 18.3 months (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26).…”

“…The management of proximal femoral fractures has had a lot of attention recently in the literature [19][20][21][22][23][24][25]. In the elderly population with unstable intertrochanteric fractures, stable fixation is essential to allow early mobilization and to minimize the risk of morbidity and mortality.…”

“…TAD was <25 mm in 29 patients (90.6%) and 25 mm in 3 patients (9.4%). The mean tip-apex distance was 15.5 mm (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). The early postoperative and last follow-up mean collo-diaphyseal angles were 129.18 (120-1408) and 128.68 (120-1358), respectively (p > 0.05).…”

Intertrochanteric femur fractures in the elderly treated with either proximal femur nailing or hemiarthroplasty: A prospective randomised clinical study

“…Intertrochanteric fractures represent the most common geriatric fracture and remain a topic of vivid discussion for the trauma surgeon [12][13][14][15][16][17].…”

N‐Acetyl Cysteine Treatment Restores Early Phase Fracture Healing in Ethanol‐Fed Rats

“…Chronic consumption of alcohol (“alcoholism”) compromises host defense to pathogens and to traumatic injury prolonging recovery from injury (Greiffenstein and Molina, ; Szabo and Mandrekar, ). Alcoholics experience more complications during the first few weeks after fracture‐fixation surgery (Faroug et al., ; Mathog et al., ; Nyquist et al., ; Serena‐Gomez and Passeri, ), which often includes infections in bone (Duckworth et al., ; Ovaska et al., ; Senel et al., ; Tonnesen et al., ), surgical site infections in the soft tissue, and other (aseptic) wound‐healing problems (Bonnevialle et al., ; Hoiness et al., ; Rantala et al., ). In fact, in fracture models of alcoholism, bone regeneration is inhibited by the tumor necrosis factor (TNF)‐α and interleukin (IL)‐1 signaling axis as demonstrated by the direct effect of cytokine antagonists on increased bone formation (Perrien et al., ; Wahl et al., ).…”