The Outcome of Patients with Herpes Zoster

Moragas, José M. de

doi:10.1001/archderm.1957.01550140037006

“…age distribution, incidence, seasonality and morbidity) is similar between Canada and the United Kingdom and is consistent with studies in other developed countries [1,6,[31][32][33][34][35][36][37][38][39]. Though sentinel reporting may overestimate the proportion of cases in older age groups (due to a larger proportion consulting their physicians), most consultations are for childhood infection.…”

Section: Discussionsupporting

confidence: 82%

Epidemiology of varicella zoster virus infection in Canada and the United Kingdom

Brisson

¹

,

Edmunds

²

,

Law

³

et al. 2001

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SUMMARYMany countries are currently studying the possibility of mass vaccination against varicella. The objective of this study was to provide a comprehensive picture of the pre-vaccine epidemiology of the varicella zoster virus (VZV) to aid in the design of immunization programs and to adequately measure the impact of vaccination. Population-based data including physician visit claims, sentinel surveillance and hospitalization data from Canada and the United Kingdom were analysed. The key epidemiological characteristics of varicella and zoster (age specific consultation rates, seasonality, force of infection, hospitalization rates and inpatient days) were compared. Results show that the overall epidemiology of varicella and zoster is remarkably similar between the two countries. The major difference being that, contrary to Canada, the epidemiology of varicella seems to be changing in the United Kingdom with an important decrease in the average age at infection that coincides with a significant increase in children attending preschool. Furthermore, differences exist in the seasonality between the United Kingdom and Canada, which seem to be primarily due to the school calendar. These results illustrate that school and preschool contact patterns play an important role in the dynamics of varicella. Finally, our results provide baseline estimates of varicella and zoster incidence and morbidity for VZV vaccine effectiveness and cost-effectiveness studies.

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“…age distribution, incidence, seasonality and morbidity) is similar between Canada and the United Kingdom and is consistent with studies in other developed countries [1,6,[31][32][33][34][35][36][37][38][39]. Though sentinel reporting may overestimate the proportion of cases in older age groups (due to a larger proportion consulting their physicians), most consultations are for childhood infection.…”

Section: Discussionsupporting

confidence: 84%

“…Zoster consultation rates are thus likely to be a reasonable estimate of incidence rates. Similar to other industrialized countries [37,39], more than 60 % of zoster cases in Canada and the United Kingdom are in adults over 45 years old. The highest rate of zoster is in 65j year olds [34,38] and seems to be increasing in the elderly population.…”

Section: Discussionmentioning

confidence: 67%

Epidemiology of varicella zoster virus infection in Canada and the United Kingdom – CORRIGENDUM

Brisson¹,

Edmunds

²

,

Law³

et al. 2014

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SUMMARYMany countries are currently studying the possibility of mass vaccination against varicella. The objective of this study was to provide a comprehensive picture of the pre-vaccine epidemiology of the varicella zoster virus (VZV) to aid in the design of immunization programs and to adequately measure the impact of vaccination. Population-based data including physician visit claims, sentinel surveillance and hospitalization data from Canada and the United Kingdom were analysed. The key epidemiological characteristics of varicella and zoster (age specific consultation rates, seasonality, force of infection, hospitalization rates and inpatient days) were compared. Results show that the overall epidemiology of varicella and zoster is remarkably similar between the two countries. The major difference being that, contrary to Canada, the epidemiology of varicella seems to be changing in the United Kingdom with an important decrease in the average age at infection that coincides with a significant increase in children attending preschool. Furthermore, differences exist in the seasonality between the United Kingdom and Canada, which seem to be primarily due to the school calendar. These results illustrate that school and preschool contact patterns play an important role in the dynamics of varicella. Finally, our results provide baseline estimates of varicella and zoster incidence and morbidity for VZV vaccine effectiveness and cost-effectiveness studies.

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“…Indeed, PHN is by far the most common complication of herpes zoster (Hope-Simpson, 1965;Easterbrook and Wood, 1995). As with the disease itself, the incidence of PHN also increases with age (de Moragas and Kierland, 1957;Guess et al, 1985;Harding et al, 1987). For example, PHN (defined as pain at 1 month or more) is relatively unusual in patients under 50 years, yet occurs in around 50% of patients aged 60 years (de Moragas and Kierland, 1957).…”

Section: Introductionmentioning

confidence: 99%

“…As with the disease itself, the incidence of PHN also increases with age (de Moragas and Kierland, 1957;Guess et al, 1985;Harding et al, 1987). For example, PHN (defined as pain at 1 month or more) is relatively unusual in patients under 50 years, yet occurs in around 50% of patients aged 60 years (de Moragas and Kierland, 1957). Although there are several risk factors for PHN (Dworkin and Portenoy, in press), it is not presently possible to identify which patients with herpes zoster will develop PHN.…”

Section: Introductionmentioning

confidence: 99%

Assessment of pain in herpes zoster: lessons learned from antiviral trials

Dworkin

¹

,

Carrington

²

,

Cunningham

³

et al. 1997

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Pain typically accompanies acute herpes zoster and, in a proportion of patients, it persists well beyond rash healing. Pain must therefore be analyzed in trials of antiviral agents in herpes zoster, but different methods have been used to analyze pain in recent published trials. These reports are reviewed and their methodological strengths and weaknesses examined. Based on this review, recommendations for the design and analysis of future trials of antiviral agents in herpes zoster are proposed. The principal recommendation is that antiviral efficacy should be evaluated both by distinguishing post-herpetic neuralgia from acute pain and by considering pain as a continuum. The primary endpoint should address both the prevalence and duration of post-herpetic neuralgia and should be examined in those patients who have post-herpetic neuralgia. Adopting the proposed recommendations in design and analysis of future trials should facilitate comparison across trials of the efficacy of antiviral agents in the treatment of herpes zoster.

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The Outcome of Patients with Herpes Zoster

Cited by 340 publications

References 1 publication

Epidemiology of varicella zoster virus infection in Canada and the United Kingdom

Epidemiology of varicella zoster virus infection in Canada and the United Kingdom

Epidemiology of varicella zoster virus infection in Canada and the United Kingdom – CORRIGENDUM

Assessment of pain in herpes zoster: lessons learned from antiviral trials

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