The Outcome of Patients with Melanoma Is Not Associated with the Time Point of Lymphatic Mapping with Respect to Excisional Biopsy of the Primary Tumor

Gauwerky, Katharina; Kunte, Christian; Geimer, Till; Baumert, Jens; Flaig, Michael J.; Ruzicka, Thomas; Schmid‐Wendtner, Monika‐Hildegard; Berking, Carola

doi:10.1159/000300047

Cited by 2 publications

(4 citation statements)

References 45 publications

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“…Gauwerky et al . compared OS and DFS in patients who had undergone tumour excision and SLNB simultaneously or consecutively; no significant differences were found between groups (Table c).…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐three studies met all criteria and were included in the study. These evaluated 18 332 patients treated between 1979 and 2009, representing data from 11 European countries (Denmark, Estonia, Finland, France, Germany, Italy, Norway, Poland, Sweden, The Netherlands and the United Kingdom) (Table ). Of these studies, 21 were observational and two were RCTs (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Four observational studies evaluated one‐step vs. two‐step surgery: two retrospectively analysed registry or database studies, a multi‐centre retrospective study and a retrospective single‐centre study (Table c). McKenna et al .…”

Section: Resultsmentioning

confidence: 99%

“…The favourable effect of SNLB reported by Leiter et al was sustained in multivariate analysis (P = 0.003), 26 but the DFS benefit reported by Calista et al was not. 36 Surgical outcomes of malignant melanoma in Europe One-vs. two-step surgery Four observational studies evaluated one-step vs. two-step surgery: two retrospectively analysed registry or database studies, 19,25 a multi-centre retrospective study 21 and a retrospective single-centre study 24 (Table 3c).…”

Section: The Effect Of Surgerymentioning

confidence: 99%

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Surgical outcomes in patients with cutaneous malignant melanoma in Europe – a systematic literature review

Svedman

Spanopoulos

Taylor

et al. 2016

Acad Dermatol Venereol

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There is limited comparative evidence of the outcomes of different types of surgical management in patients with malignant melanoma in Europe. To address that gap we conducted a systematic literature review to summarize studies reporting outcomes of surgical procedures in patients with malignant melanoma in Europe. Medline was searched for European studies published in English, between 2004 and 2014 reporting surgical outcomes in adults with cutaneous malignant melanoma. We identified 23 studies that evaluated 18 332 patients treated surgically between 1979 and 2009 from 11 European countries. Most of the studies (21/23) were observational; the two remaining studies were randomized controlled trials (RCTs). Studies compared the effect of a range of surgical interventions on a range of clinical outcomes, more commonly overall survival (OS) and disease-free survival (DFS)/recurrence-free survival (RFS). Wider excisions were not associated with improved survival in patients with melanoma thickness ≥2 mm in both studies (RCTs), however, recent results based on long-term follow-up data associate 3 cm excision margins (vs. 1 cm) with favourable survival outcomes. There was some evidence that complete lymph node dissection after positive sentinel lymph node offers survival benefits over therapeutic lymph node dissection. Sentinel lymph node biopsy was not shown to be associated with significant OS benefits, however, it was overly related with higher rates of DFS/RFS. This review highlights the difficulties of making comparisons between different types of surgical procedures for malignant melanoma. As surgery remains the main treatment, this is an important field, and further evidence, particularly from RCTs, is needed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%