The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development

Dai, Bai; Liang, Hao; Guo, Dongdong; Bi, Zhao-Wei; Yuan, Jiangzi; Jin, Yifeng; Lei, Huan Yao; Guo, Xudong; Cang, Ming; Liu, Dongjun

doi:10.3390/ani10010075

Cited by 19 publications

(10 citation statements)

References 53 publications

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“…GLYATL2 is related to fat synthesis and it was significantly upregulated. KRT4 upregulation suggests significant increase in cell proliferation to promote SHF development and also increase cashmere yield [60]. Elevated expression of SLC1A2 suggests that it may promote hair growth and keratinocyte proliferation [61].…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus)

Qin²,

et al. 2022

BMC Vet Res

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Background Among the world’s finest natural fiber composites is derived from the secondary hair follicles (SHFs) of cashmere goats yield one of the world's best natural fibres. Their development and cycling are characterized by photoperiodism with diverse, well-orchestrated stimulatory and inhibitory signals. Long non-coding RNA (lncRNAs) and mRNAs play important roles in hair follicle (HF) development. However, not many studies have explored their specific functions in cashmere development and cycling. This study detected mRNAs and lncRNAs with their candidate genes and related pathways in SHF development and cycling of cashmere goat. We utilized RNA sequencing (RNA-Seq) and bioinformatics analysis on lncRNA and mRNA expressions in goat hair follicles to discover candidate genes and metabolic pathways that could affect development and cycling (anagen, catagen, and telogen). Results We identified 228 differentially expressed (DE) mRNAs and 256 DE lncRNA. For mRNAs, catagen and anagen had 16 upregulated and 35 downregulated DEGs, catagen and telogen had 18 upregulated and 9 downregulated DEGs and telogen and anagen had 52 upregulated and 98 downregulated DEGs. LncRNA witnessed 22 upregulated and 39 downregulated DEGs for catagen and anagen, 36 upregulated and 29 downregulated DEGs for catagen and telogen as well as 66 upregulated and 97 downregulated DEGs for telogen and anagen. Several key genes, including MSTRG.5451.2, MSTRG.45465.3, MSTRG.11609.2, CHST1, SH3BP4, CDKN1A, GAREM1, GSK-3β, DEFB103A KRTAP9–2, YAP1, S100A7A, FA2H, LOC102190037, LOC102179090, LOC102173866, KRT2, KRT39, FAM167A, FAT4 and EGFL6 were shown to be potentially important in hair follicle development and cycling. They were related to, WNT/β-catenin, mTORC1, ERK/MAPK, Hedgehog, TGFβ, NFkB/p38MAPK, caspase-1, and interleukin (IL)-1a signaling pathways. Conclusion This work adds to existing understanding of the regulation of HF development and cycling in cashmere goats via lncRNAs and mRNAs. It also serves as theoretical foundation for future SHF research in cashmere goats.

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Section: Discussionmentioning

confidence: 99%

Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus)

Qin²,

et al. 2022

BMC Vet Res

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“…At present, studies have shown that Wnt, Shh, TGF-b, Notch, NF-kappa B, and PPAR signal pathways may be related to cashmere development [ 33 , 34 , 35 , 36 , 37 ]. In this study, we enriched six KEGG pathways in positive and negative modes, among which cholesterol metabolism, primary bile acid biosynthesis, and bile secretion were enriched in both ion modes ( Table 3 , 4).…”

Section: Discussionmentioning

confidence: 99%

“…The three pathways were annotated with four highly significant differences in metabolites: taurochenodeoxycholate, cholic acid, taurochenodeoxycholic acid, and glycochenodeoxycholic acid. Lactosylceramidase I in skin fibroblasts can be stimulated by pure taurocholate, while lactosylceramidase II can be stimulated by taurocholate or pure sugar deoxycholate, taurine deoxycholate, and taurine goose deoxycholate to catalyze the hydrolysis of lactose ceramide [ 33 ]. Cholesterol is crucial to the physiology of the skin and is a component of epidermal barrier function [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolomic Analysis and MRM Verification of Coarse and Fine Skin Tissues of Liaoning Cashmere Goat

Cai²,

Chen³

et al. 2022

Molecules

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One of the critical elements in evaluating the quality of cashmere is its fineness, but we still know little about how it is regulated at the metabolic level. In this paper, we use UHPLC–MS/MS detection and analysis technology to compare the difference in metabolites between coarse cashmere (CT_LCG) and fine cashmere (FT_LCG) skin of Liaoning cashmere goats. According to the data, under positive mode four metabolites were significantly up-regulated and seven were significantly down-regulated. In negative mode, seven metabolites were significantly up-regulated and fourteen metabolites were significantly down-regulated. The two groups’ most significant metabolites, Gly–Phe and taurochenodeoxycholate, may be crucial in controlling cashmere’s growth, development, and fineness. In addition, we enriched six KEGG pathways, of which cholesterol metabolism, primary bile acid biosynthesis, and bile secretion were enriched in positive and negative modes. These findings offer a new research idea for further study into the critical elements influencing cashmere’s fineness.

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“…The Inner Mongolian cashmere goat is an important source of germplasm with high economic value (Wu et al, 2020b). Cashmere is finer, stronger, lighter, and softer than wool, and it looks like a luxury fiber (Dai et al, 2019). Historically, wool played an important role in the economy of Portugal and Spain in the 15th century and Britain, Australia, and New Zealand since the beginning of the industrial revolution in the 18th century (Plowman et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Identification of the key proteins associated with different hair types in sheep and goats

et al. 2022

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Animal-derived fiber has the characteristics of being light, soft, strong, elastic and a good thermal insulator, and it is widely used in many industries and traditional products, so it plays an important role in the economy of some countries. Variations in phenotypes of wool fibers among different species and breeds are important for industry. We found that the mean fiber diameter of cashmere was significantly smaller than that of sheep wool (p < 0.01), and sheep wool was significantly smaller than goat wool (p < 0.01). Compared with traditional proteomics technology, we analyzed cashmere, guard hair, and wool by Laber-free proteomics technology and detected 159, 204, and 70 proteins, respectively. Through the sequential windowed acquisition of all theoretical fragmentations (SWATH), 41 and 54 differentially expressed proteins were successfully detected in the cashmere vs. wool group and guard hair vs. wool group. Protein‒protein interaction network analysis of differentially expressed proteins revealed many strong interactions related to KRT85, KRTAP15-1 and KRTAP3-1. The final analysis showed that the proportion of KRT85, KRTAP15-1 and KRTAP3-1 might be the key to the difference in fiber diameter and could be used as a potential molecular marker for distinguishing different fiber types.

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The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development

Cited by 19 publications

References 53 publications

Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus)

Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus)

Metabolomic Analysis and MRM Verification of Coarse and Fine Skin Tissues of Liaoning Cashmere Goat

Identification of the key proteins associated with different hair types in sheep and goats

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