The overview and prospects of BNCT facility at Tsing Hua Open-pool reactor

Jiang, Shiang‐Huei; Liu, Yen-Wan Hsueh; Chou, Fong‐In; Liu, Hongming; Peir, Jinn-Jer; Liu, Yuanhao; Huang, Yu-Shiang; Wang, Ling-Wei; Chen, Yiwei; Yen, Sang‐Hue; Wu, Yuan‐Hung; Liu, Ching-Sheng; Lee, Jia-Cheng; Chang, Chun Ju; Wang, Shyh-Jen; Huang, Wen‐Sheng; Kai, Ji-Jung

doi:10.1016/j.apradiso.2020.109143

Cited by 9 publications

(9 citation statements)

References 5 publications

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“…Reactor-based boron neutron capture therapy is available for compassionate use. 33 Intensity modulated radiotherapy, including volumetric-modulated arc therapy, is covered by the NHI and has become standard of care for thoracic radiotherapy. Stereotactic body radiation therapy or stereotactic ablative radiotherapy is also covered for medically inoperable early stage lung cancer.…”

Section: Radiation Approachesmentioning

confidence: 99%

Lung Cancer in Republic of China

Luo¹,

Chiu

Kuo

et al. 2021

Journal of Thoracic Oncology

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Section: Radiation Approachesmentioning

confidence: 99%

Lung Cancer in Republic of China

Luo¹,

Chiu

Kuo

et al. 2021

Journal of Thoracic Oncology

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“…于常规放疗 [24] 。2010 年起，新竹清华大学和台北荣民总医院开始联合进行头颈部肿瘤的 BNCT 临床试验 [25] ，用新竹清华大学的反应堆，首次试验治疗 10 例患者，静脉滴注 BPA 400 mg/kg，…”

Section: 第二代硼携带剂unclassified

Boron delivery agents for boron neutron capture therapy

Li¹,

Luo²

2021

Chin. Sci. Bull.

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“…Boron Neutron Capture Therapy (BNCT) epithermal beam irradiation at Tsing Hua Open-pool Reactor (THOR), a 2-MW rated power research reactor activated in 1961, started its commissioning after the completion of BNCT facility’s construction in 2005 [ 1 ]. Since then, the attention of many scientists and researchers of different specialties was drawn to BNCT for related investigations, such as animal or cell irradiation, at National Tsing Hua University (NTHU).…”

Section: Introductionmentioning

confidence: 99%

NeuTHOR Station—A Novel Integrated Platform for Monitoring BNCT Clinical Treatment, Animal and Cell Irradiation Study at THOR

Huang

Peir

et al. 2023

Life

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(1) Background: A well-established Boron Neutron Capture Therapy (BNCT) facility includes many essential systems, which are the epithermal neutron beam system, on-line monitoring system (OMS), QA/QC (quality assurance or quality control) system, boron concentration (BC) measurement system, and treatment planning system (TPS). Accurate data transmission, monitoring, and deposition among these systems are of vital importance before, during, and after clinical, animal, and cell BNCT irradiation. This work developed a novel integrated platform NeuTHOR Station (NeuTHORS) for BNCT at Tsing Hua Open-pool Reactor (THOR). Apart from the data of the OMS and QA/QC system, the data of BC and TPS can be loaded on NeuTHORS before BNCT clinical, animal, and cell irradiation. (2) Methods: A multi-paradigm computer programming language c# (c sharp) was used to develop the integrated platform NeuTHORS. The design of NeuTHORS is based on the standard procedures of BNCT treatment or experiment at THOR. Moreover, parallel testing with OMS-BNCT (the former OMS) and QA/QC of THOR was also performed for more than 70 times to verify the validation of NeuTHORS. (3) Results: According to the comparisons of the output, NeuTHORS and OMS-BNCT and QA/QC of THOR show very good consistency. NeuTHORS is now installed on an industrial PC (IPC) and successfully performs the monitoring of BNCT Treatment at THOR. Patients’ f BC and TPS data are also input into NeuTHORS and stored on IPC through an internal network from BC measurement room and TPS physicist. Therefore, the treatment data of each patient can be instantaneously established after each BNCT treatment for further study on BNCT. NeuTHORS can also be applied on data acquisition for a BNCT-related study, especially for animal or cell irradiation experiments. (4) Conclusions: A novel integrated platform NeuTHOR Station for monitoring BNCT clinical treatment and animal and cell irradiation study has been successfully established at THOR. With this platform, BNCT radiobiology investigations will be efficiently performed and a thorough data storage and analysis system of BNCT treatments or experiments can thus be systematically built up for the further investigation of BNCT at THOR.

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The overview and prospects of BNCT facility at Tsing Hua Open-pool reactor

Cited by 9 publications

References 5 publications

Lung Cancer in Republic of China

Lung Cancer in Republic of China

Boron delivery agents for boron neutron capture therapy

NeuTHOR Station—A Novel Integrated Platform for Monitoring BNCT Clinical Treatment, Animal and Cell Irradiation Study at THOR

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