The Oxidant/Antioxidant Network: Role of Melatonin

Reiter, R. J.; Tan, Dun‐Xian; Cabrera, Javier; D’Arpa, Daniele; Sainz, Rosa M.; Mayo, Juan C.; Ramos, Sofı́a

doi:10.1159/000014569

Cited by 260 publications

(147 citation statements)

References 61 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…MLT also has substantial free radical scavenging/antioxidant and anticancer activity in experimental systems (45,60,61,63). This knowledge has obvious relevance to human health (22,26,54,60,61,66,79).…”

Section: Melatonin and Human Breast Cancer Cell Growthmentioning

confidence: 99%

Lighting for the human circadian clock: recent research indicates that lighting has become a public health issue

Pauley¹

2004

Medical Hypotheses

325

229

View full text Add to dashboard Cite

The hypothesis that the suppression of melatonin (MLT) by exposure to light at night (LAN) may be one reason for the higher rates of breast and colorectal cancers in the developed world deserves more attention. The literature supports raising this subject for awareness as a growing public health issue.Evidence now exists that indirectly links exposures to LAN to human breast and colorectal cancers in shift workers. The hypothesis begs an even larger question: has medical science overlooked the suppression of MLT by LAN as a contributor to the overall incidence of cancer?The indirect linkage of breast cancer to LAN is further supported by laboratory rat experiments by David E. Blask and colleagues. Experiments involved the implanting of human MCF-7 breast cancer cell xenografts into the groins of rats and measurements were made of cancer cell growth rates, the uptake of Linoleic Acid (LA), and MLT levels. One group of implanted rats were placed in light-dark (12L: 12D) and a second group in light-light (12L:12L) environments. Constant light suppressed MLT, increased cancer cell growth rates, and increased LA uptake into cancer cells. The opposite was seen in the light-dark group. The proposed mechanism is the suppression of nocturnal MLT by exposure to LAN and subsequent lack of protection by MLT on cancer cell receptor sites which allows the uptake of LA which in turn enhances the growth of cancer cells.MLT is a protective, oncostatic hormone and strong antioxidant having evolved in all plants and animals over the millennia. In vertebrates, MLT is normally produced by the pineal gland during the early morning hours of darkness, even in nocturnal animals, and is suppressed by exposure to LAN.Daily entrainment of the human circadian clock is important for good human health. These studies suggest that the proper use and color of indoor and outdoor lighting is important to the health of both 2 humans and ecosystems. Lighting fixtures should be designed to minimize interference with normal circadian rhythms in plants and animals.New discoveries on blue-light-sensitive retinal ganglion cell light receptors that control the circadian clock and how those receptors relate to today's modern high intensity discharge (HID) lamps are discussed. There is a brief discussion of circadian rhythms and light pollution. With the precautionary principle in mind, practical suggestions are offered for better indoor and outdoor lighting practices designed to safeguard human health. SummaryStudies now indirectly link exposures of shift workers to LAN and higher incidences of breast

show abstract

Section: Melatonin and Human Breast Cancer Cell Growthmentioning

confidence: 99%

Lighting for the human circadian clock: recent research indicates that lighting has become a public health issue

Pauley¹

2004

Medical Hypotheses

325

229

View full text Add to dashboard Cite

show abstract

“…Êð³ì òîãî, â³í º äîñèòü åôåêòèâíèì àíòèîêñè-äàíòîì, ÿêèé ïîãëèíàº ñèíãëåòíèé êèñåíü, ñóïåðîêñèäíèé àí³îí, ïåðîêñèí³òðèò ³ îêñèä àçîòó [24,26]. Ïðè öüîìó éîãî àêòèâí³ñòü í à á à ã à ò î á ³ ë ü ø à ï î ð ³ â í ÿ í î ç ³ í ø è ì è â³äîìèìè ñêàâåíäaeåðàìè â³ëüíèõ ðàäèêàë³â [24,25]. Àíòèîêñèäàíòí³ âëàñòèâîñò³ ìåëàòîí³íó ïðîÿâëÿþòüñÿ ³ â éîãî çäàòíîñò³ àêòèâóâàòè ôåðìåíòè ïåðåòâîðåííÿ ³íøîãî ïîòóaeíîãî àíòèîêñèäàíòà ãëóòàò³îíó [1,10], äåô³öèò ÿêîãî ïîêàçàíèé ïðè ÕÏ òà ³íøèõ ñòàíàõ ñòàíàõ, ïîâÿçàíèõ ç íåñòà-Ðèñ.…”

Section: ðåçóëüòàòè òà ¯õ îáãîâîðåííßunclassified

Untitled

2009

Fiziol Zh

View full text Add to dashboard Cite

“…that result in changes in sleep and circadian biological rhythms. In some of these studies, in addition to sleep enhancements, the antioxidant properties of this hormone were the main reason for testing this pineal hormone (Reiter, 1998;Reiter et al, 1999;Reiter et al, 2000;Reiter et al, 2003). In a recent publication, Vankirk et al (2017), using a Drosophila model, demonstrated that injection of melatonin increases the regularity of heartbeat significantly, and it can rescue rhythmicity in flies bearing mutations that adversely affect cardiac function.…”

Section: Introductionmentioning

confidence: 99%

Valeriana officinalis and melatonin: Evaluation of the effects in Drosophila melanogaster rapid iterative negative geotaxis (RING) test

Cheuczuk¹,

Freitas²,

Vaz³

et al. 2017

J. Med. Plants Res.

View full text Add to dashboard Cite

The rapid iterative negative geotaxis (RING) assay is a commonly used behavioral test in Drosophila based on digital imaging of flies and requires minimal equipment and space. Larval mobility can be used to reliably determine the effect of drugs on locomotion in Drosophila larvae. The effects of Valeriana officinalis extract (VoE) and melatonin (ME) were tested in Drosophila melanogaster flies and larvae. In the RING assay, the locomotor activity of flies was reduced to 30.6, 72 and 70.4% when exposed to 10 mg/ml VoE, 8 mM ME, and a combination of 8 mM ME + 10 mg/ml VoE, respectively. The performance index (PI) was reduced to 68.9% (P = 0.0058), 33.3% (P = 0.0001), and 70% (P = 0.0013) when flies were exposed to 8 mM ME, 10 mg/ml VoE, and a combination of 8 mM ME + 10 mg/ml VoE, respectively. The number of body wall contractions of Drosophila larvae (nBWC) was reduced to 47.8, 37.7 and 38.5% when larvae were exposed to 8 mM ME, 10 mg/ml VoE, and a combination of 8 mM ME + 10 mg/ml VoE, respectively. The displacement velocity (V 0 ) of larvae decreased significantly to 67.6, 60.1 and 55.6% when larvae were exposed to 8 mM ME, 10 mg/ml VoE, and a combination of 10 mg/ml VoE + 8 mM ME, respectively (P < 0.05). The effects of the VoE extract were not synergistic with ME as demonstrated by the RING assay, nBWC, and V 0 . Based on these results, valerian root extracts have demonstrated sedative effects that are better than those of melatonin in fruit flies, but did not show any increase in sedative effect when combined with melatonin.

show abstract

The Oxidant/Antioxidant Network: Role of Melatonin

Cited by 260 publications

References 61 publications

Lighting for the human circadian clock: recent research indicates that lighting has become a public health issue

Lighting for the human circadian clock: recent research indicates that lighting has become a public health issue

Untitled

Valeriana officinalis and melatonin: Evaluation of the effects in Drosophila melanogaster rapid iterative negative geotaxis (RING) test

Contact Info

Product

Resources

About