The oxidation of molecular tritium in mammals

Smith, G. N.; Emerson, Ray Jenkins; Temple, L.A.; Galbraith, Ted W.

doi:10.1016/0003-9861(53)90166-0

Cited by 8 publications

(2 citation statements)

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“…Studies utilizing tritium, a hydrogen radioisotope, have revealed that most hydrogen absorbed by mammalian cells is rapidly excreted from the body, and hydrogen is not oxidized in the organs [ 3 ]. A portion of hydrogen is converted to water, a process facilitated by microorganisms such as intestinal bacteria [ 20 ]. However, in aqueous solutions, hydrogen reacts with free radicals in the body.…”

Section: Properties Of Hydrogenmentioning

confidence: 99%

“…However, certain enzymes known as hydrogenases in bacteria can utilize hydrogen as an energy source or as a byproduct of anaerobic metabolism [ 24 ]. In contrast, mammalian cells lack hydrogenase genes, leading to the assumption that hydrogen serves no function in mammals [ 20 ]. In 1975, Dole et al reported that hydrogen gas significantly regressed skin tumors in animals, but this finding did not gain widespread attention [ 25 ].…”

Section: Antioxidant Effects Of Hydrogenmentioning

confidence: 99%

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Health Benefits of Electrolyzed Hydrogen Water: Antioxidant and Anti-Inflammatory Effects in Living Organisms

Hu,

Kabayama,

Watanabe

et al. 2024

Antioxidants

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Molecular hydrogen, the smallest and lightest molecule, serves as an intense reducing agent. Its distinct characteristics, including minimal size and neutral charge, enhance bioavailability and facilitate significant biological effects. Previously considered physiologically inert, hydrogen has gained recognition as a powerful therapeutic agent, known for its antioxidative and anti-inflammatory properties. Electrolyzed hydrogen water (EHW), enriched with molecular hydrogen, demonstrates remarkable antioxidative capabilities, indicating potential benefits for various diseases. Inflammation-induced reactive oxygen species (ROS) amplify inflammation, leading to secondary oxidative stress and creating a crosstalk between ROS and inflammatory responses. This crosstalk contributes to the pathogenesis and progression of chronic diseases. EHW interrupts this crosstalk, reducing inflammatory cytokines and oxidative stress across various disease models, suggesting therapeutic potential. EHW is also known for its anti-inflammatory effects, extending to pain management, as evidenced in models like sciatic nerve ligation and inflammatory pain. In an inflammatory bowel disease (IBD) model, EHW effectively alleviates abdominal pain, mitigating 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced inflammation and oxidative stress, offering insights for clinical applications. Additionally, hydrogen selectively targets harmful radicals, and EHW intake helps balance stress-induced hormonal dysregulation, potentially easing disorders associated with chronic stress.

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Section: Properties Of Hydrogenmentioning

confidence: 99%