The oxygen radical disease in neonatology

Saugstad, Ola Didrik

doi:10.1007/bf02722373

Cited by 31 publications

(25 citation statements)

References 29 publications

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“…The effects of carbon dioxide seem to depend on the level to which the lung is exposed with significant changes mostly obtained at 8% CO 2 . These results in addition to the already noted reduction both of pulmonary inflammation [81], and oxygen-mediated radical disease [82], support the use of CO 2 as therapy [83,84], hypothesizing a role as a protective agent against VILI. However carbon dioxide should be used carefully, particularly on extremely low birth weight infants during the first days of life, avoiding both higher values and large fluctuations in PaCO 2 , to minimize effects on the neurodevelopmental outcomes [85].…”

Section: Carbon Dioxide (Co 2 )supporting

confidence: 59%

Current Applications of Therapeutic Gases in Neonatal Intensive Care

Migliori¹,

Garzoli²,

Chirico

2010

CPR

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Various gases are utilized in respiratory care. Though oxygen is the most frequently administered, the use of other gases has become common practice in recent years. This report reviews the literature concerning some of the therapeutic gases utilized in Neonatal Intensive Care Unit (NICU). Inhaled Nitric Oxide is a selective pulmonary vasodilator largely employed in the Intensive Care Units. Its effects are well known as well as cost/effectiveness and consequently limitations, mainly in the developed countries. An alternative gas with comparable characteristics is Onitrosoethanol. In experimental studies, this gas seems to improve oxygenation and systemic haemodynamics, reducing the rebound hypoxaemia and the production of toxic by-products. Helium-oxygen mixture is less common, although it is widely known to both the decrease the pressure required to ventilate the lung and the resistive work of breathing, improving gas exchange in particular clinical conditions. Recent studies showed its efficacy and feasibility both in infants and in preterms. Carbon dioxide is usually employed for the management of some specific congenital heart defects characterised by various grades of pulmonary vascular resistance. Its major effect is the reduction of pulmonary blood flow to decrease cardiac work. The Xenon, already known for its anaesthetic proprieties although rarely used, has recently been considered for neuroprotection, opening a new field of interest in neonatal hypoxia/ischemia syndrome.

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Section: Carbon Dioxide (Co 2 )supporting

confidence: 59%

Current Applications of Therapeutic Gases in Neonatal Intensive Care

Migliori¹,

Garzoli²,

Chirico

2010

CPR

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“…The time that infants spent within the intended SpO 2 range increased significantly, and was accompanied by a reduced proportion of time in hyperoxemia and a trend toward less time with hypoxemia during including hypoxemic events, are associated with retinopathy of prematurity and may lead to impaired neurologic outcomes in preterm infants. 1,4,14 Although previous studies using the same ventilator and Clio system indicated a significant improvement in oxygenation by reducing the total time in hyperoxemia, the total time in severe hypoxemia, and the number of prolonged hypoxemic events, these studies have reported slight increases in the total proportion of time below the intended oxygen saturation range. 11,15 In those 2 previous studies, infants' demographic characteristics were similar to those in our subjects, although the mode of ventilation and targeted SpO 2 differed.…”

Section: Discussionmentioning

confidence: 91%

Effects of Automated Adjustment of the Inspired Oxygen on Fluctuations of Arterial and Regional Cerebral Tissue Oxygenation in Preterm Infants with Frequent Desaturations

Waitz¹,

Schmid²,

Fuchs³

et al. 2015

The Journal of Pediatrics

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“…54 The peculiar perinatal susceptibility to OS indicates that prophylactic use of antioxidants such as melatonin could help prevent or reduce oxidative injury related to these diseases in newborns. 11 Fetal melatonin is of maternal origin and undergoes circadian fluctuations in synchrony with the day-night rhythm.…”

Section: Perinatal Asphyxiamentioning

confidence: 99%