The oxygen uptake efficiency slope in children with congenital heart disease: construct and group validity

Abstract

The OUES provides a valid measure of cardiopulmonary fitness in children with CHD, which is independent of exercise intensity and strongly correlated with VO(2peak) and VT (construct validity). Furthermore, the OUES is capable of differentiating between healthy children and children with CHD and between Fontan and ToF patients (group validity). Therefore, the OUES may be a valid, effort-independent parameter of cardiopulmonary fitness in children with CHD.

An evaluation of the validity of the pre‐operative oxygen uptake efficiency slope as an indicator of cardiorespiratory fitness in elderly patients scheduled for major colorectal surgery

“…Most studies found no significant differences between maximal and submaximal oxygen uptake efficiency slope values [19,21,22,24,25,28], whereas other studies reported small differences [14,18,20,26]. Most studies found no significant differences between maximal and submaximal oxygen uptake efficiency slope values [19,21,22,24,25,28], whereas other studies reported small differences [14,18,20,26].…”

“…Figure 3 Receiver operator curves for predicting a peak oxygen uptake ≤ 18.2 ml.kg À1 .min À1 (left graph) and a ventilatory anaerobic threshold ≤ 11.1 ml.kg À1 .min À1 (right graph) from the oxygen uptake efficiency slope normalised for body mass calculated using all exercise data ( ), 90% of the data ( ) and 80% of the data ( ). 14, [18][19][20][21][22][23][24][25][26][27][28][29][30] and indicates that the oxygen uptake efficiency slope is an objective measure of cardiorespiratory fitness. The two patients (both men, 72.3 and 75.9 years of age) who had a difference of > 200 between OUES100 and OUES80 values, demonstrated a consistent levelling-off of oxygen uptake during the last part of the cardiopulmonary exercise test, without showing a clear oxygen uptake plateau (see Fig.…”

“…There are, however, several clinical limitations when determining cardiorespiratory fitness using peak oxygen uptake and/or the ventilatory anaerobic threshold; moreover, assessing only these two measures leads to substantial loss of physiological data. The oxygen uptake efficiency slope has been reported to correlate strongly with well-established measures of cardiorespiratory fitness such as peak oxygen uptake and the ventilatory anaerobic threshold in different groups of adults and children [18][19][20][21][22][23][24][25][26][27][28][29][30]. One such parameter, the oxygen uptake efficiency slope (OUES), has been reported to have prognostic value in predicting major cardiac events and mortality in patients with heart failure and coronary artery disease [14][15][16][17].…”

“…The theoretical linearity of the oxygen uptake efficiency slope implies that it does not require a maximal effort and can thus be derived rather accurately from submaximal exercise data as well. The oxygen uptake efficiency slope has been reported to correlate strongly with well-established measures of cardiorespiratory fitness such as peak oxygen uptake and the ventilatory anaerobic threshold in different groups of adults and children [18][19][20][21][22][23][24][25][26][27][28][29][30]. The oxygen uptake efficiency slope has also been found to have excellent test-retest reliability in general surgical patients, with a reliability coefficient (95%CI) of 0.89 (0.81-0.97) [31].…”

The oxygen uptake efficiency slope is not a valid surrogate of aerobic fitness in cystic fibrosis

“…Previous studies have assessed the validity of the OUES in clinical populations, such as congestive heart failure and congenital heart disease, finding it, to an extent, to be a suitable, effort‐independent, parameter of aerobic fitness. Moreover, two previous studies have assessed the applicability of the OUES in individuals with CF.…”