The oxytocin/vasopressin receptor antagonist atosiban delays the gastric emptying of a semisolid meal compared to saline in human

Ohlsson, Bodil; Björgell, Ola; Ekberg, Olle; Darwiche, Gassan

doi:10.1186/1471-230x-6-11

Cited by 37 publications

(80 citation statements)

References 23 publications

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“…OT is released in response to a fatty meal in women (16). Systemic administration of atosiban, the antagonist of OT receptor (OTR), inhibited the spontaneous contraction of gallbladder in rabbits (12) and gastric emptying in humans (16). It has been well established that mRNA for OT and its receptor can be found throughout the human GI tract (15), but the cell types that express OTR were undetectable in human gut by indirect immunofluorescence (19).…”

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confidence: 99%

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Estradiol upregulates the expression of oxytocin receptor in colon in rats

Feng

Qin²,

Wang³

et al. 2009

American Journal of Physiology-Endocrinology and Metabolism

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The study was designed to investigate the effect of estradiol on the excitatory effect of oxytocin (OT) on colon motility. Female Wistar rats were used, and some of them were ovariectomized (OVX) and treated with vehicle or estradiol (E2). A plastic balloon made of condom was inserted into colon to monitor the change of colonic pressure in vivo. Longitudinal muscle strips of distal colon were prepared to monitor the spontaneous contraction of colon in vitro. Expression of OT receptor (OTR) was investigated by Western blot analysis. Expression of OTR mRNA was detected by RT-PCR. Immunohistochemistry was used to locate OTR. In OVX rats, pretreatment of E2 (4 -100 g/kg sc) dose-dependently increased the excitatory effect of OT on colon motility both in vivo and in vitro and increased the expression of OTR and OTR mRNA in colon. Systemic administration of OT excited the colon motility in vivo in rats at perioda of proestrus and estrus but did not influence it at diestrus period, when the concentration of plasma E2 was lowest in the estrous cycle. Pretreatment of atosiban, the specific OTR antagonist, and TTX, the blocker of voltage-dependent sodium channel on nerve fiber, attenuated the excitatory effect of OT on colon motility. OTR was located in myenteric plexus of colon. These results suggested that E2 increased the excitatory effect of OT on colon motility by upregulating the expression of OTR in myenteric plexus.colon; motility OXYTOCIN (OT) has been traditionally regarded as a hormone that is involved in parturition and milk ejection. In recent years, more evidence has indicated that OT may play a role in regulation of the gastrointestinal (GI) functions such as motility, sensation (13, 18), and immune response to inflammation (4, 10). Exogenous OT influences the GI motility, although the reports are diverse because of the differences of species, methods, and area of the gut (18, 24). It has been suggested that the effect of OT on GI motility might be physiological. OT is released in response to a fatty meal in women (16). Systemic administration of atosiban, the antagonist of OT receptor (OTR), inhibited the spontaneous contraction of gallbladder in rabbits (12) and gastric emptying in humans (16). It has been well established that mRNA for OT and its receptor can be found throughout the human GI tract (15), but the cell types that express OTR were undetectable in human gut by indirect immunofluorescence (19).In women, colonic dysmotility is very common, and bowel function changes during the reproductive cycle. Although the fluctuation of steroid hormones, especially estradiol (E 2 ) and progesterone, were believed to be the major reason, the mechanism has not been clearly illustrated. Steroid hormones regulate the activity of OTR via both genomic and nongenomic pathways (26). E 2 induced the mRNA expression of the OTR and increased the OTR density on the membranes of the uterine smooth muscle and central nervous system (8, 21). The recent study of our group also indicated that the pretreatment of E 2 increas...

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confidence: 99%

“…It has been suggested that the effect of OT on GI motility might be physiological. OT is released in response to a fatty meal in women (16). Systemic administration of atosiban, the antagonist of OT receptor (OTR), inhibited the spontaneous contraction of gallbladder in rabbits (12) and gastric emptying in humans (16).…”

mentioning

confidence: 99%

Estradiol upregulates the expression of oxytocin receptor in colon in rats

Feng

Qin²,

Wang³

et al. 2009

American Journal of Physiology-Endocrinology and Metabolism

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“…AVP has been shown to increase the gastric and duodenal motility in humans and rabbits (Ohlsson et al, 2006;Li et al, 2007), as well as colonic peristalsis, but the expression of the AVP receptors in intestine has not been examined yet (Ohlsson et al, 2006). Some authors have demonstrated that AVP increase the gastro-intestinal motility via the oxytocin OT1 receptors, but the experiment is only for stomach and duodenum from rabbits (Li et al, 2007).…”

Section: Does Avp Have An Importance For the Motility Of The Gastro-imentioning

confidence: 99%

“…Dose-dependent effects of AVP on gastro-intestinal tract from different species were observed, but regarding the rectal musculature the information is insufficient and controversial (Ohlsson et al, 2006). AVP has been shown to increase the gastric and duodenal motility in humans and rabbits (Ohlsson et al, 2006;Li et al, 2007), as well as colonic peristalsis, but the expression of the AVP receptors in intestine has not been examined yet (Ohlsson et al, 2006).…”

Section: Does Avp Have An Importance For the Motility Of The Gastro-imentioning

confidence: 99%

The Effects of Some Neuropeptides on Motor Activity of Smooth Muscle Organs in Abdominal and Pelvic Cavities

Toleкova¹,

Hadzhibozheva²,

Georgiev³

et al. 2012

Neuroendocrinology and Behavior

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“…Ancak, Borg ve ark. (19) tarafından yapılan bir çalış-mada OT infüzyonunu takiben mide boşalma hızında hiçbir anlamlı değişiklik olmadığı gösterilirken, araştırıcılar tarafından OT reseptör antagonisti atosiban (ATO) uygulanmasının ise mide boşalmasını geciktirdiği belirtilmiştir. Ohlsson ve ark.…”

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