The oxytocin/vasopressin receptor family has at least five members in the gnathostome lineage, inclucing two distinct V2 subtypes

Daza, Daniel Ocampo; Lewicka, Michalina; Larhammar, Dan

doi:10.1016/j.ygcen.2011.10.011

Cited by 80 publications

(65 citation statements)

References 51 publications

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“…infusions of a V 1a antagonist, which produced no effect on pair bonding [23]. However, nonapeptides may potentially influence pair bonding via actions at multiple other receptor types, including the VT1 receptor (a V 2b receptor [35]), which is distributed in numerous brain areas [27], and the OT-like VT3 receptor. Because the VT3 receptor appears to be promiscuous [34], the OTA effects observed in the present study may reflect the actions of endogenous MT, VT or both.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin-like receptors mediate pair bonding in a socially monogamous songbird

Klatt

Goodson

2013

Proc. R. Soc. B.

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Although many species form socially monogamous pair bonds, relevant neural mechanisms have been described for only a single species, the prairie vole (Microtus ochrogaster). In this species, pair bonding is strongly dependent upon the nonapeptides oxytocin (OT) and vasopressin, in females and males, respectively. Because monogamy has evolved many times in multiple lineages, data from additional species are required to determine whether similar peptide mechanisms modulate bonding when monogamy evolves independently. Here we test the hypothesis that OT-like receptor activation is required for pair bond formation in the socially monogamous zebra finch (Taeniopygia guttata). Males and females were administered chronic intracerebroventricular infusions of saline or an OT receptor antagonist and were observed twice daily for 3 days in a colony environment. A variety of affiliative, aggressive and other behaviours were quantified. The antagonist produced significant and selective effects on pair bonding (latency to pair; number of sessions paired; stable pairing) and the associated behaviour of allopreening. Importantly, findings for males follow the trends of females; this yields main effects of treatment in two-way ANOVAs, although within-sex analyses are significant only for females. These data provide evidence for both convergent evolution and species diversity in the neuroendocrine mechanisms of pair bonding.

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Section: Discussionmentioning

confidence: 99%

Oxytocin-like receptors mediate pair bonding in a socially monogamous songbird

Klatt

Goodson

2013

Proc. R. Soc. B.

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“…Spotted gar and southern platyfish also have the three V2 subtypes, indicating that all of them arose early in vertebrate evolution (Lagman et al 2013). In an earlier study, the V2CR was described in zebrafish and threespined stickleback as a V2-like receptor (Ocampo Daza et al 2012). Lagman et al (2013) also described two V2BR subtypes (V2B1 and V2B2) in the southern platyfish.…”

Section: Introductionmentioning

confidence: 98%

“…In elephant fish (Holocephali), Yamaguchi et al (2012) described two V2 receptor subtypes: V2A (conventional form; cAMP signaling) and V2B (PKC signaling). The V2AR is orthologous to mammalian V2 receptor and V2BR is orthologous to avian V2 receptor (Ocampo Daza et al 2012). The V2BR is subdivided into type 1 fish-specific and type 2, found in tetrapods.…”

Section: Introductionmentioning

confidence: 99%

Molecular cloning, sequencing and phylogeny of vasotocin receptor genes in the air-breathing catfish Heteropneustes fossilis with sex dimorphic and seasonal variations in tissue expression

Rawat

Chaube

Joy

2015

Fish Physiol Biochem

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Vasotocin (VT) is the ortholog of vasopressin (VP) in non-mammalian vertebrates and is known for multiple functions. Teleost fishes have a complete repertoire of known VP/VT receptor subtypes (vasopressin type, VR): two V1A subtypes (V1Aa and V1Ab or V1a1 and V1a2) and five V2 subtypes (V2A1, V1A2, V2B1, V2B2 and V2C). Full-length cDNAs of v1a1, v1a2 and v2 (v2a1) with ORFs of 1,308, 1,137 and 1,527 bp, respectively, were cloned and characterized in the catfish Heteropneustes fossilis (Siluriformes, Ostariophysi). BLAST analysis revealed that the genes encoded three VT receptors, V1a1, V1a2 and V2 of 436, 379 and 509 amino acid residues, respectively. The predicted proteins showed typical features of the seven-transmembrane domain receptor core structure with hallmark triplets Asp-Arg-Tyr/Asp-Arg-His (DRY/DRH) and the variable intracellular loop III of vertebrate neurohypophysial hormone receptors. Phylogenetic analysis of the deduced protein sequences revealed that they clustered with the V1Aa, V1Ab and V2A1, respectively, of other teleosts. The V2R has a sequence identity of 70-76% with V2A1 than with the V2B type (sequence identity 43-49%). Semiquantitative PCR analysis showed that the receptor gene transcripts were expressed ubiquitously in the tissues examined (brain, pituitary, gonads, liver, muscle, kidney and gills) and displayed sex and seasonal fluctuations in a tissue-specific manner. The results form a basis for functional studies on the VT receptors in the catfish.

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“…No fewer than 14 terms are currently used to identify the numerous VP and OT variants, and thus for clarity, we here use "VP" and "OT" to refer to all known homologs of the canonical mammalian forms. We likewise use mammalian nomenclature for their receptors, consistent with recent definitive works on the vertebrate nonapeptide receptors (14).…”

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confidence: 99%

Hypothalamic oxytocin and vasopressin neurons exert sex-specific effects on pair bonding, gregariousness, and aggression in finches

Kelly

Goodson

2014

Proc. Natl. Acad. Sci. U.S.A.

102

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Antagonism of oxytocin (OT) receptors (OTRs) impairs the formation of pair bonds in prairie voles (Microtus ochrogaster) and zebra finches (Taenioypygia guttata), and also reduces the preference for the larger of two groups ("gregariousness") in finches. These effects tend to be stronger in females. The contributions of specific peptide cell groups to these processes remain unknown, however. This issue is complicated by the fact that OTRs in finches and voles bind not only forms of OT, but also vasopressin (VP), and >10 cell groups produce each peptide in any given species. Using RNA interference, we found that knockdown of VP and OT production in the paraventricular nucleus of the hypothalamus exerts diverse behavioral effects in zebra finches, most of which are sexually differentiated. Our data show that knockdown of VP production significantly reduces gregariousness in both sexes and exerts sexspecific effects on aggression directed toward opposite-sex birds (increases in males; decreases in females), whereas OT knockdown produces female-specific deficits in gregariousness, pair bonding, and nest cup ownership; reduces side-by-side perching in both sexes; modulates stress coping; and induces hyperphagia in males. These findings demonstrate that paraventricular neurons are major contributors to the effects of VP-OT peptides on pair bonding and gregariousness; reveal previously unknown effects of sex-specific peptide on opposite-sex aggression; and demonstrate a surprising lack of effects on same-sex aggression. Finally, the observed effects of OT knockdown on feeding and stress coping parallel findings in mammals, suggesting that OT modulation of these processes is evolutionarily conserved across the amniote vertebrate classes.vasotocin | mesotocin | social behavior N umerous pharmacological studies, such as those using sitespecific infusions of agonists and antagonists, have demonstrated that the vasopressin (VP)-oxytocin (OT) nonapeptides modulate diverse behaviors, including parental care, aggression, communication, sexual behavior, affiliation, anxiety, pair bonding, and stress response (1-3). Such manipulations do not allow us to infer the functions of specific VP-OT neuronal populations, however, because the peptides are produced in numerous cell groups, at least some of which give rise to widespread and longdistance paracrine modulation, including release from axons, dendrites, and soma (4-6). The various VP-OT cell groups also exhibit overlapping axonal projections, and thus any given brain area potentially receives peptides from many different sources (4). Indeed, there is an extremely high potential for overlapping modulation from the various cell groups, because numerous brain areas produce OT and VP in any given species. For instance, 20 different forebrain areas produce OT in the mustached bat (Pteronotus parnellii) (7), and sites of VP production are comparably numerous (8). Importantly, even the smallest of these populations, such as the accessory VP populations of the anterior hypothalamus (AH)...

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The oxytocin/vasopressin receptor family has at least five members in the gnathostome lineage, inclucing two distinct V2 subtypes

Cited by 80 publications

References 51 publications

Oxytocin-like receptors mediate pair bonding in a socially monogamous songbird

Oxytocin-like receptors mediate pair bonding in a socially monogamous songbird

Molecular cloning, sequencing and phylogeny of vasotocin receptor genes in the air-breathing catfish Heteropneustes fossilis with sex dimorphic and seasonal variations in tissue expression

Hypothalamic oxytocin and vasopressin neurons exert sex-specific effects on pair bonding, gregariousness, and aggression in finches

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