The P300 component decreases in a bimodal oddball task in individuals with depression: An event-related potentials study

Cai, Nan; Wang, Gaohua; Wang, Huiling; Wan, Xiaoping; Liu, Zhongchun; Xiao, Ling; Bai, Hanping; Wu, Shihao

doi:10.1016/j.clinph.2018.09.012

Cited by 44 publications

(38 citation statements)

References 32 publications

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“…In the current study, a significantly decreased stimulus‐locked P300 to flanker stimuli was found in a group of individuals with current depression compared to never depressed individuals. This finding is in line with past reports of depression characterized by diminished P300 amplitude in auditory oddball tasks (Bruder et al, ; Gangadhar et al, ; Nan et al, ; Roschke & Wagner, ; Urretavizcaya et al, ). Findings on P300 in depression using Go/No‐Go tasks are much more mixed: some studies fail to find significant differences in P300 between participants with depression and healthy participants (Kaiser et al, ; Ruchsow et al, ), even with relatively large sample sizes (Quinn, Harris, & Kemp, ).…”

Section: Discussionsupporting

confidence: 92%

“…Thus, our findings indicate a blunted P300 in depression occurring independently of clinical subtypes and symptom severity levels. While this is at odds with some previous findings (Ancy et al, 1996;Gangadhar et al, 1993;Hansenne et al, 1996;Nan et al, 2018;Urretavizcaya et al, 2003), it is worth noting that most of these studies varied considerably in the clinical characteristics that were linked to P300 and were based on rather small clinical sample sizes, that is, n < 25 in all but the Nan et al (n = 45) and Urretavizcaya et al (n = 50) studies. Since the P300 amplitude has been functionally associated with attentional allocation and processing of motivationally relevant stimuli, the generic reduction in this component is consistent with the broad impairment of neuropsychological functioning that is observed in depression (Rock et al, 2014;Snyder, 2013).…”

Section: Discussionmentioning

confidence: 81%

“…Several studies have reported a reduction in P300 amplitudes to infrequent target stimuli in individuals with current depressive disorders (Bruder et al, 2009;Gangadhar, Ancy, Janakiramaiah, & Umapathy, 1993;Roschke & Wagner, 2003;Urretavizcaya et al, 2003). There is some indication that this P300 effect might be modulated by depression severity (Gangadhar et al, 1993;Nan et al, 2018), increased suicidality (Hansenne, Pitchot, Gonzalez Moreno, Zaldua, & Ansseau, 1996), or specific subtypes of depression, such as the melancholic subtype (Ancy, Gangadhar, & Janakiramaiah, 1996;Gangadhar et al, 1993;Urretavizcaya et al, 2003).…”

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confidence: 99%

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Reduced P300 in depression: Evidence from a flanker task and impact on ERN, CRN, and Pe

et al. 2020

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Individuals with current depression show reduced amplitude of the P300 component of the stimulus‐locked event‐related potential (ERP)—an effect most often examined in oddball tasks. Although imperative stimuli in response‐monitoring paradigms (e.g., the flanker task), also elicit a P300, it is unclear whether a blunted P300 can be observed in depression in these tasks. Moreover, the P300 overlaps with the correct‐response negativity (CRN) and error‐related negativity (ERN), and is similar to the error positivity (Pe)—response‐locked ERPs frequently examined in flanker tasks. The current study examined the stimulus‐locked P300 and response‐monitoring ERPs on error (i.e., ERN, Pe) and correct responses (i.e., CRN) during an arrowhead flanker task in 72 individuals with a current depressive disorder and 42 never depressed healthy individuals. Consistent with findings from oddball tasks, P300 amplitude was reduced among participants with depression. Further, results indicated increased ERN and CRN, and decreased Pe, in depression. However, when the blunted P300 was included in analyses, group differences in response‐monitoring ERPs were no longer evident. Accordingly, P300 amplitudes were correlated negatively with the ERN/CRN and positively with Pe in both groups. A blunted P300 in depression can be observed in speeded response tasks, and can produce apparent increases in ERN and CRN due to ERP component overlap. Further, reduced Pe in participants with depression may reflect a reduced P300 to error commission. These data highlight the central role of reduced P300 in clinical depression, and demonstrate that this effect can be observed across both stimulus‐ and response‐locked ERPs in speeded response tasks.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 81%

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confidence: 99%

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Reduced P300 in depression: Evidence from a flanker task and impact on ERN, CRN, and Pe

et al. 2020

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“…P3 amplitude reduction has also been associated with internalizing problems. The strongest associations have been with depression, where several studies have found greater reductions in P3 for depressed populations compared to control groups (Baribeau‐Braun & Lesevre, 1983; Blackwood et al., 1987; Deldin, Keller, Gergen, & Miller, 2001; Diner, Holcomb, & Dykman, 1985; Enoch, White, Harris, Rohrbaugh, & Goldman, 2001; Gangadhar, Ancy, Janakiramaiah, & Umapathy, 1993; Nan et al., 2018; Pfefferbaum, Wenegrat, Ford, Roth, & Kopell, 1984; Röschke & Wagner, 2003; Singh, Shukla, Dalal, Sinha, & Trivedi, 2000; Thier, Axman, & Giedke, 1986). Additional avenues of research have explored whether the particular type of depression has an effect on P3.…”

Section: Introductionmentioning

confidence: 99%

P3 amplitude reductions are associated with shared variance between internalizing and externalizing psychopathology

et al. 2020

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P3 amplitude reductions, commonly elicited in oddball paradigms, have been associated with both internalizing (e.g., depression and anxiety) and externalizing problems (e.g., substance use, aggression, and impulsivity). Recent factor analytic models have focused on the shared variance between internalizing and externalizing problems as a potentially important separable psychopathology construct (a general psychopathology factor, or p‐factor). To assess neurophysiological markers of this shared variance, we examined P3 amplitude to target and novel stimuli in an undergraduate sample with a range of internalizing and externalizing problems. Participants (N = 125) completed a rotated heads visual oddball paradigm, with IAPS pictures serving as infrequent novel stimuli. Results replicated P3 amplitude reduction relative to both target and novel stimuli separately for internalizing and externalizing problems, and found that the shared variance across internalizing and externalizing was significantly related to lower P3 amplitude to novels, targets, and a factor score of target and novel P3 measures. The present results are consistent with the interpretation that a general or shared problem behavior factor accounts for much of the associations between reduced P3 amplitude and internalizing and externalizing problems.

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“…This was a preliminary exploratory study that provided an opportunity to understand the underlying neural mechanism of the crossmodal emotional disorder of MADs. More importantly, previous studies suggested that the crossmodal emotional integration disorder not only effectively predicted or evaluated the early stage of the development of substance addiction (Lannoy et al, 2017) but also improved the sensitivity of clinical diagnosis (Kajosch et al, 2016;Nan et al, 2018), which could be beneficial for explaining the relationship between crossmodal emotional dysfunction and clinical disease (Brandwein et al, 2015). This study offered a new suggestion for preventing and improving the emotional cognitive impairment of substance addictions as well as clinical interventions and treatment (Tinga et al, 2016;Nattala et al, 2018).…”

Section: Discussionmentioning

confidence: 77%

Facilitation of Crossmodal Integration During Emotional Prediction in Methamphetamine Dependents

Zhang

et al. 2020

Front. Neural Circuits

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Methamphetamine (meth) can greatly damage the prefrontal cortex of the brain and trigger dysfunction of the cognitive control loop, which triggers not only drug dependence but also emotional disorders. The imbalance between the cognitive and emotional systems will lead to crossmodal emotional deficits. Until now, the negative impact of meth dependence on crossmodal emotional processing has not received attention. Therefore, the present study firstly examined the differences in crossmodal emotional processing between healthy controls and meth dependents (MADs) and then investigated the role of visual-or auditory-leading cues in the promotion of crossmodal emotional processing. Experiment 1 found that MADs made a visual-auditory integration disorder for fearful emotion, which may be related to the defects in information transmission between the auditory and auditory cortex. Experiment 2 found that MADs had a crossmodal disorder pertaining to fear under visual-leading cues, but the fearful sound improved the detection of facial emotions for MADs. Experiment 3 reconfirmed that, for MADs, A-leading cues could induce crossmodal integration immediately more easily than V-leading ones. These findings provided sufficient quantitative indicators and evidences that meth dependence was associated with crossmodal integration disorders, which in turn was associated with auditory-leading cues that enhanced the recognition ability of MADs for complex emotions (all results are available at: https://osf. io/x6rv5/). These results provided a better understanding for individuals using drugs in order to enhance the cognition for the complex crossmodal emotional integration.

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The P300 component decreases in a bimodal oddball task in individuals with depression: An event-related potentials study

Cited by 44 publications

References 32 publications

Reduced P300 in depression: Evidence from a flanker task and impact on ERN, CRN, and Pe

Reduced P300 in depression: Evidence from a flanker task and impact on ERN, CRN, and Pe

P3 amplitude reductions are associated with shared variance between internalizing and externalizing psychopathology

Facilitation of Crossmodal Integration During Emotional Prediction in Methamphetamine Dependents

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