The p38 MAPK Pathway in Prostate Cancer

Djakiew, Daniel

doi:10.1007/978-1-4614-6828-8_8

Prostate Cancer 2013

DOI: 10.1007/978-1-4614-6828-8_8

|View full text |Cite

The p38 MAPK Pathway in Prostate Cancer

Daniel Djakiew

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer

Alshammari¹,

Zhang²,

Yang³

2022

WJG

View full text Add to dashboard Cite

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal neoplasms worldwide and represents the vast majority of pancreatic cancer cases. Understanding the molecular pathogenesis and the underlying mechanisms involved in the initiation, maintenance, and progression of PDAC is an urgent need, which may lead to the development of novel therapeutic strategies against this deadly cancer. Here, we review the role of SET and MYND domain-containing protein 2 (SMYD2) in initiating and maintaining PDAC development through methylating multiple tumor suppressors and oncogenic proteins. Given the broad substrate specificity of SMYD2 and its involvement in diverse oncogenic signaling pathways in many other cancers, the mechanistic extrapolation of SMYD2 from these cancers to PDAC may allow for developing new hypotheses about the mechanisms driving PDAC tumor growth and metastasis, supporting a proposition that targeting SMYD2 could be a powerful strategy for the prevention and treatment of PDAC.

show abstract

Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer

Alshammari¹,

Zhang²,

Yang³

2022

WJG

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The p38 MAPK Pathway in Prostate Cancer

Cited by 1 publication

References 71 publications

Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer

Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer

Contact Info

Product

Resources

About