The P50 evoked potential component and mismatch detection in normal volunteers: implications for the study of sensory gating

Boutros, Nashaat N.; Torello, Michael W.; Barker, Brandy A.; Tueting, Patricia; Wu, Shengbao; Nasrallah, Henry A.

doi:10.1016/0165-1781(95)02637-c

Cited by 76 publications

(34 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to prior research, learning effects on the P1 responses were not correlated with learning effects on the other components of neural responses (Boutros & Belger, 1999;Boutros et al, 1995;Kisley, Noecker, & Guinther, 2004). For example, previous studies suggested that statistical learning effects on P1 responses were more detectable in musicians than non-musicians, whereas those on N1 responses did not differ between musicians and nonmusicians (Paraskevopoulos et al, 2012).…”

Section: Discussionmentioning

confidence: 98%

Pitch-class distribution modulates the statistical learning of atonal chord sequences

Daikoku

Yatomi

Yumoto

2016

Brain and Cognition

View full text Add to dashboard Cite

a b s t r a c tThe present study investigated whether neural responses could demonstrate the statistical learning of chord sequences and how the perception underlying a pitch class can affect the statistical learning of chord sequences. Neuromagnetic responses to two chord sequences of augmented triads that were presented every 0.5 s were recorded from fourteen right-handed participants. One sequence was a series of 360 chord triplets, each of which consisted of three chords in the same pitch class (clustered pitch-classes sequences). The other sequence was a series of 360 chord triplets, each of which consisted of three chords in different pitch classes (dispersed pitch-classes sequences). The order of the triplets was constrained by a first-order Markov stochastic model such that a forthcoming triplet was statistically defined by the most recent triplet (80% for one; 20% for the other two). We performed a repeated-measures ANOVA with the peak amplitude and latency of the P1m, N1m and P2m. In the clustered pitch-classes sequences, the P1m responses to the triplets that appeared with higher transitional probability were significantly reduced compared with those with lower transitional probability, whereas no significant result was detected in the dispersed pitch-classes sequences. Neuromagnetic significance was concordant with the results of familiarity interviews conducted after each learning session. The P1m response is a useful index for the statistical learning of chord sequences. Domain-specific perception based on the pitch class may facilitate the domain-general statistical learning of chord sequences.

show abstract

Section: Discussionmentioning

confidence: 98%

Pitch-class distribution modulates the statistical learning of atonal chord sequences

Daikoku

Yatomi

Yumoto

2016

Brain and Cognition

View full text Add to dashboard Cite

show abstract

Section: Mep@sourcesignalcommentioning

confidence: 99%

“…For example, the P50 suppression effect (Boutros et al 1995;Clementz et al 1997) is a temporal nonlinearity whereby an auditory evoked component at about 50 msec post-stimulus is modified by the precedence (within about 500 msec) of an identical click stimulus. In other words, the brain system generating the evoked response is not linearly characterized by the response to a single stimulus: Temporal context affects the evoked response to primary stimulus information.…”

Section: Mep@sourcesignalcommentioning

confidence: 99%

Combating fuzziness with computational modeling

Talamini¹,

Meeter²,

Murre³

2003

Behav Brain Sci

View full text Add to dashboard Cite

Cognitive neuroscience provides a new conceptual framework for psychiatry by showing how psychological processes arise from neuronal activity (Kandel 1998). Conversely, it is possible that psychiatry will influence the future development of cognitive neuroscience by encouraging a better balance between localist and holistic conceptions of brain function. An apparent conflict between these conceptions has been central to the development of neuroscience, with the emphasis upon locally specialized functions emerging as clearly dominant. Neuroanatomy, neurophysiology, neuropsychology, and neuroimaging all show that different regions of the brain process information about different things, and that different cells within regions deal with different aspects of those things. Recent developments in experimental and theoretical neurobiology, however, are leading to an increased emphasis upon interactions that coordinate the activity of locally specialized processors. Here we argue that impairment of these coor-BEHAVIORAL AND BRAIN SCIENCES (2003) Abstract:The concept of locally specialized functions dominates research on higher brain function and its disorders. Locally specialized functions must be complemented by processes that coordinate those functions, however, and impairment of coordinating processes may be central to some psychotic conditions. Evidence for processes that coordinate activity is provided by neurobiological and psychological studies of contextual disambiguation and dynamic grouping. Mechanisms by which this important class of cognitive functions could be achieved include those long-range connections within and between cortical regions that activate synaptic channels via NMDAreceptors, and which control gain through their voltage-dependent mode of operation. An impairment of these mechanisms is central to PCP-psychosis, and the cognitive capabilities that they could provide are impaired in some forms of schizophrenia. We conclude that impaired cognitive coordination due to reduced ion flow through NMDA-channels is involved in schizophrenia, and we suggest that it may also be involved in other disorders. This perspective suggests several ways in which further research could enhance our understanding of cognitive coordination, its neural basis, and its relevance to psychopathology.Keywords: attention; cerebral cortex; cognitive coordination; cognitive neuropsychiatry; cognitive neuropsychology; context disorganization; Gamma rhythms; Gestalt theory; glutamate; grouping; memory; NMDA-receptors; PCP-psychosis; perceptual organization; schizophrenia William A. Phillips, Ph.D., is Professor of Neuropsychology at the University of Stirling, Scotland UK. He has published more than 70 papers on vision, visual memory, perceptual learning, childrens drawings, the effects of brain damage on reading and writing, and the theory of neuronal computation. He was a founder and the first Director of the Center for Cognitive and Computational Neuroscience at the University of Stirling.Steven M. Silverstein, Ph.D., is A...

show abstract

“…Commonly, a decrement in amplitude of the second AEP response relative to the first AEP response is found. This response suppression has been referred to as the P50 gating [23] or sensory gating [19]. Sensory gating is believed to be a complex, multifaceted physiological function protecting higher cortical centres from being flooded with incoming irrelevant sensory stimuli [19].…”

Section: Introductionmentioning

confidence: 99%

“…An often-employed passive, single-stimulus paradigm that studies the effects of stimulus repetition on auditory evoked potentials (AEPs) is the 'double-click' or 'twotone' paradigm [8,[19][20][21][22]. This paradigm involves the presentation of pairs of stimuli in a close (i.e.…”

Section: Introductionmentioning

confidence: 99%

Effects of Diazepam on Auditory Evoked Potentials of Rats Elicited in a Ten-Tone Paradigm

Jongsma

Rijn²,

Schaijk³

et al. 2000

Neuropsychobiology

View full text Add to dashboard Cite

The effect of diazepam on sensory gating was studied in rats by measuring diazepam effects on auditory evoked potentials (AEPs) elicited in a ten-tone paradigm. Trains of 10 repetitive tone-pip stimuli were presented. Rats (n = 8) received 4 mg·kg^–1 diazepam subcutaneously or vehicle, counterbalanced over two sessions. Diazepam decreased the amplitude of the middle-latency P₃₀ component and increased the amplitudes of the late-latency N₆₀ and P₆₇ components. The increase in the late-latency components might be due to a diazepam-induced decrease in arousal. Stimulus repetition decreased the amplitudes of the middle-latency N₁₈ and P₃₀ components in both conditions. This suggests that automated neuronal recovery functions underlying sensory gating remain intact with diazepam. In the vehicle condition, the amplitude of the late-latency P₆₇ decreased with stimulus repetition, but not in the diazepam condition. This suggests a diazepam-induced decrease of behaviourally mediated habituation.

show abstract

The P50 evoked potential component and mismatch detection in normal volunteers: implications for the study of sensory gating

Cited by 76 publications

References 18 publications

Pitch-class distribution modulates the statistical learning of atonal chord sequences

Pitch-class distribution modulates the statistical learning of atonal chord sequences

Combating fuzziness with computational modeling

Effects of Diazepam on Auditory Evoked Potentials of Rats Elicited in a Ten-Tone Paradigm

Contact Info

Product

Resources

About